Format:
Online-Ressource
,
Ill., graph. Darst.
Edition:
Online-Ausg. 2009 Electronic reproduction; Available via World Wide Web
ISBN:
9783527607853
,
3527311416
,
1280854294
,
9783527311415
,
9781280854293
Content:
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinica
Content:
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinica
Note:
Includes bibliographical references and index
,
Parallel als Buch-Ausg. erschienen
,
Autoantibodies and Autoimmunity; Contents; Preface; List of Contributors; Part 1 Introductory Chapters; 1 Introduction; 1.1 Background; 1.2 Autoimmunity; 1.3 Autoantibodies as Diagnostic Markers; 1.4 Autoantibodies as Molecular and Cellular Probes; 1.5 Autoantibodies in Experimental Models of Autoimmunity; 1.6 Conclusions; References; 2 Prefatory Chapter: The Importance of the Autoantibody-defined Epitope; 2.1 Introduction; 2.2 The Uniqueness of the Autoantibody-defined Antigenic Determinant or the Autoepitope; 2.2.1 The Highly Conserved Nature of the Autoepitope
,
2.2.2 The Autoepitope Resides at or in Close Proximity to the Functional Region or Binding Site of the Antigen2.2.3 The Autoepitope is Composed of Conformation-dependent Discontinuous Sequences of the Antigen; 2.3 Conclusions; References; Part 2 Autoimmunity; 3 Self/Non-self Recognition; 3.1 Introduction; 3.2 Immunological Self; 3.2.1 Burnet's Self-marker Hypothesis; 3.2.2 A Confusion of Level: Adaptive Enzymes; 3.2.3 The Boundaries of Self; 3.2.4 Prenatal Tolerance: Testing the Model; 3.3 The Clonal Selection Theory; 3.3.1 Immune Theories of Natural Selection; 3.3.2 Clonal Selection
,
3.3.3 Corollaries of the Clonal Selection Theory3.4 Self Post-Burnet; 3.4.1 The Immunologists' Dirty Little Secret; 3.4.2 The Missing Self Hypothesis; 3.5 Conclusions; References; 4 Central and Peripheral Tolerance; 4.1 Introduction; 4.2 Ignorance of Lymphocytes to Target Antigen; 4.3 Central T-cell Tolerance; 4.3.1 Tolerance Due to Negative T-cell Selection; 4.3.1.1 Aire-driven Peripheral Antigen Expression in Medullary Thymic Epithelial Cells; 4.3.2 Self-tolerance Associated with Positive T-cell Selection
,
4.3.3 Self-tolerance Due to Thymus-derived Regulatory T Cells: Natural Regulatory T Cells4.4 Peripheral T-cell Tolerance; 4.4.1 Self-tolerance Due to Regulatory T Cells Generated in the Periphery: Adaptive Regulatory T Cells; 4.4.2 T-cell Anergy; 4.4.3 Activation-induced Cell Death; 4.5 B-cell Tolerance; 4.5.1 Negative Selection of B Cells; 4.5.2 B-cell Receptor Editing; 4.5.3 B-cell Anergy; 4.6 Breaking Tolerance; 4.7 Concluding Remarks; References; 5 T-B Cell Interactions in Autoimmunity; 5.1 Introduction; 5.2 Direct T-B Cell Interactions: Receptor-mediated Contacts; 5.2.1 CD40-CD154
,
5.2.2 CD28 System5.2.3 Other Costimulatory Systems; 5.2.4 Cell Death; 5.3 Indirect T-B Cell Interactions: Soluble Mediators; 5.3.1 Th1 versus Th2 Cytokines in Humoral Autoimmunity; 5.3.2 IFN-γ; 5.3.3 IL-4; 5.3.4 IL-6; 5.3.5 IL-10; 5.3.6 Other Cytokines; 5.4 The Nature of T-B Interactions in Autoimmunity: Ongoing Issues; References; 6 Cell Death and Autoimmunity; 6.1 Introduction; 6.2 Apoptosis; 6.2.1 Mechanistic Events in Apoptosis; 6.3 Necrosis; 6.3.1 Mechanistic Events in Necrosis; 6.4 Impaired Lymphocyte Cell Death and Autoimmunity
,
6.5 Cell Death-associated Autoantigen Proteolysis and Autoimmunity
,
Literaturangaben
,
Electronic reproduction; Available via World Wide Web
Additional Edition:
3527607854
Additional Edition:
3527607226
Additional Edition:
9783527607853
Additional Edition:
9783527607228
Additional Edition:
3527607854
Additional Edition:
9783527311415
Additional Edition:
Print version Autoantibodies and Autoimmunity
Language:
English
Subjects:
Medicine
Keywords:
Autoimmunität
;
Autoaggressionskrankheit
;
Diagnose
;
Autoantikörper
;
Aufsatzsammlung
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