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  • 1
    Online Resource
    Online Resource
    Amsterdam [u.a.] : Elsevier, Acad. Press
    UID:
    (DE-602)b3kat_BV042241843
    Format: 1 Online-Ressource (XXXVI, 942 S.) , Ill., graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943 , 0123741947
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Pharmazeutische Chemie ; Klinische Chemie ; Einführung
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Book
    Book
    Amsterdam [u.a.] : Elsevier, Acad. Press
    UID:
    (DE-602)b3kat_BV035008961
    Format: XXXVI, 942 S. , Ill., graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943 , 0123741947
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Pharmazeutische Chemie ; Klinische Chemie ; Einführung
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  • 3
    Book
    Book
    Amsterdam [u.a.] : Elsevier, Acad. Press
    UID:
    (DE-604)BV035008961
    Format: XXXVI, 942 S. , Ill., graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943 , 0123741947
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Pharmazeutische Chemie ; Klinische Chemie ; Einführung
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  • 4
    Online Resource
    Online Resource
    Amsterdam : Elsevier/Academic Press
    UID:
    (DE-627)1684652812
    Format: 1 Online-Ressource (xxxvi, 942 p)
    Edition: 3rd ed
    ISBN: 9780080568775 , 0080568777 , 9780123741943 , 0123741947
    Content: Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly. This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery. NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features * New chapters including: - Drug absorption and transport - Multi-target drugs * Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics
    Note: Includes bibliographical references and index
    Additional Edition: 0123741947
    Additional Edition: Erscheint auch als Druck-Ausgabe Practice of medicinal chemistry Amsterdam ; Boston : Elsevier/Academic Press, 2008
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Electronic books
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  • 5
    Online Resource
    Online Resource
    Amsterdam : Elsevier/Academic Press
    UID:
    (DE-603)320557502
    Format: xxxvi, 942 p. , ill. (some col.), ports. (some col.) , 29 cm
    Edition: 3rd ed
    Edition: Online-Ausg. Amsterdam Elsevier Science & Technology 2008 Online-Ressource [Online-Ausg.]
    ISBN: 0123741947 , 0123741947 , 9780123741943
    Note: Includes bibliographical references and index , Online-Ausg.:
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
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    RVK:
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  • 6
    Book
    Book
    Amsterdam : Elsevier, Academic Press
    UID:
    (DE-627)566443368
    Format: XXXVI, 942 S. , Ill., graph. Darst.
    Edition: 3rd ed.
    ISBN: 9780123741943
    Note: Literaturangaben
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Pharmazeutische Chemie ; Bibliografie
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  • 7
    Online Resource
    Online Resource
    Burlington : Elsevier Science
    UID:
    (DE-627)776368648
    Format: Online-Ressource (982 p)
    Edition: 3rd ed
    ISBN: 9780123741943
    Content: Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery
    Note: Description based upon print version of record , Front Cover; The Practice of Medicinal Chemistry; Copyright Page; Contents; Biography; Section Editors; Contributors; Preface to the First Edition; Preface to the Second Edition; Preface to the Third Edition; Part I: General Aspects of Medicinal Chemistry; Chapter 1. A History of Drug Discovery; I. Introduction; A. The renewal of chemistry; B. The dawn of the organic chemistry crosses the birth of biology; II. Two Hundred Years of Drug Discoveries; A. Pain killers: best-sellers and controversies; B. Giving back the heart its youth; C. Fight against microbes and viruses , D. Drugs for immunosuppressionE. Contribution of chemists to the fight against cancer; F. Drugs for endocrine disorders; G. Anti-acid drugs; H. Lipid lowering drugs; I. From neurotransmitters to receptors; J. Drugs of the mind; III. Considerations on Recent Trends in Drug Discovery; A. From genetics to DNA technology; B. Hopes and limits for drug hunting; References; Chapter 2. Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems; I. Definitions and Objectives; A. Medicinal chemistry and related disciplines and terms; B. Drugs and drug substances , C. Stages of drug developmentII. Drug Activity Phases; A. The pharmaceutical phase; B. The pharmacokinetic phase; C. The pharmacodynamic phase; D. The road to successful drug development?; III. Drug Classification Systems; A. Classification by target and mechanism of action; B. Other classification systems; References; Chapter 3. Measurement and Expression of Drug Effects; I. Introduction; II. In Vitro Experiments; A. Binding studies; B. Ligand-receptor interaction-induced functional effects; C. Allosteric interaction; D. Expression of functional effects for targets other than GPCRS , E. Cellular and tissular functional responsesIII. Ex Vivo Experiments; IV. In Vivo Experiments; References; Chapter 4. Molecular Drug Targets; I. Introduction; A. How many drug targets for how many drugs?; B. From the drug target to the response of the organism; C. Drug binding, affinity and selectivity; D. Various ligands for a single target; II. Enzymes as Drug Targets; A. Targeting human enzymes; B. Targeting enzymes selective of invading organisms; III. Membrane Transporters as Drug Targets; A. Established drug targets among membrane transporters , B. Progress in the pharmacological control of membrane transportersIV. Voltage-Gated Ion Channels as Drug Targets; A. Voltage-gated sodium channels (Na[sub(V)] channels); B. Voltage-gated calcium channels (Ca[sub(V)] channels); C. Potassium channels; V. Non-Selective Cation Channels as Drug Targets; VI. Direct Ligand-Gated Ion Channels (Receptors with Intrinsic Ion Channel); A. P2X-ATP receptors; B. Glutamate-activated receptors; C. The ""Cys-loop receptor superfamily""; VII. Receptors with Intrinsic Enzyme Activity; A. Receptors with guanylate cyclase activity , B. Receptors with serine/threonine kinase activity
    Additional Edition: 9780080568775
    Additional Edition: Print version The Practice of Medicinal Chemistry
    Language: English
    Keywords: Electronic books
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  • 8
    Book
    Book
    Amsterdam [u.a.] : Elsevier
    UID:
    (DE-603)229261795
    Format: XXXVI, 942 S. , Ill., zahlr. graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
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  • 9
    Book
    Book
    Amsterdam [u.a.] : Elsevier
    UID:
    (DE-605)HT015568181
    Format: XXXVI, 942 S : Ill., graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943
    Note: Includes bibliographical references and index
    Language: English
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  • 10
    Online Resource
    Online Resource
    Amsterdam [u.a.] : Elsevier [u.a.]
    UID:
    (DE-605)HT016962878
    Format: XXXVI, 942 S : Ill., graph. Darst.
    Edition: 3. ed.
    ISBN: 9780123741943
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Druckausg. The practice of medical chemistry
    Language: English
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