Format:
Online-Ressource (661 p)
ISBN:
9780126457506
Content:
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.Special Features* Explain
Note:
Description based upon print version of record
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Cover image; Title page; Table of Contents; Copyright; Dedication; Preface; Foreword; Chapter 1: Introduction to the Structure, Properties, and Reactions of DNA; A. Introduction; B. The Structure of Nucleic Acids; C. The Structure of Double-Stranded DNA; D. The Biological Significance of Double Strandedness; E. Sequence-Dependent Variation in the Shape of the DNA; F. Physical Properties of Double-Stranded DNA; G. Chemicals That React with DNA; H. DNA Sequencing Strategies; I. Enzymes That Modify DNA Structure; Chapter 2: DNA Bending; A. Introduction
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B. The Wedge Model and Junction Model for DNA BendingC. Protein-Induced DNA Bending; D. The Biology of DNA Bending; E. Details of Selected Experiments; Chapter 3: DNA Supercoiling; A. Introduction; B. Heterogeneity in Forms of a DNA Molecule; C. Supercoiled Forms of DNA; D. Supercoils: Interwound or Toroidal Coils?; E. DNA Knots and Catenanes; F. Superhelical Density and the Specific Linking Difference of DNA; G. The Energetics of Supercoiled DNA; H. The Binding to Supercoiled DNA by Intercalation; I. Effects of Temperature and Salt on Helical Winding and DNA Supercoiling
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J. The Biology of Supercoiled DNAK. Details of Selected Experiments; Chapter 4: Cruciform Structures in DNA; A. Introduction; B. Formation and Stability of Cruciforms; C. Assays for Cruciform Structures in DNA; D. Evidence for the Existence of Cruciforms in Vivo; E. The Biology of Cruciforms: Do Cruciforms Have a Biological Function?; F. Specific Experiments; Chapter 5: Left-Handed Z-DNA; A. Introduction; B. The Structure of Z-DNA; C. Formation and Stability of Z-DNA; D. Assays for Z-DNA; E. Z-DNA in Vivo; F. Possible Biological Functions for Z-DNA; Chapter 6: Triplex DNA; A. Introduction
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B. Formation and Stability of Intramolecular Triple-Stranded DNAC. Assays for Intramolecular Triplex DNA; D. Evidence for the Existence of Triplex DNA in Vivo; E. The Biology of Triple-Stranded DNA; F. Intermolecular Triplex DNA; Chapter 7: Miscellaneous Alternative Conformations of DNA; A. Introduction; B. Slipped, Mispaired DNA; C. DNA Unwinding Elements; D. Parallel-Stranded DNA; E. Four-Stranded DNA; F. Anisomorphic DNA; G. Nodule DNA and Higher-Order Pu·Py Structures; H. Triplet Repeats, DNA Structure, and Human Genetic Disease; Chapter 8: DNA-Protein Interactions; A. Introduction
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B. General Considerations on Protein BindingC. Specific DNA-Protein Interactions; Chapter 9: The Organization of DNA into Chromosomes; A. Introduction; B. The Packaging of DNA in Bacterial Cells; C. The Packaging of DNA in the Eukaryotic Nucleosome; D. The Organization of Chromosomes in Cells; Bibliography; Author Index; Subject Index
Additional Edition:
9780080571737
Additional Edition:
Print version DNA Structure and Function
Language:
English
Keywords:
Electronic books
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