Format:
Online-Ressource (VI, 292 p. 20 illus., 17 illus. in color, digital)
ISBN:
9781461461111
Series Statement:
Advances in Experimental Medicine and Biology 783
Content:
This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors' recent studies and the studies of others to offer a new understanding of immunity to tuberculosis
Content:
This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed.The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection.Finally, it is a synthesis of the authors’ recent studies and the studies of others to offer a new understanding of immunity to tuberculosis
Note:
Description based upon print version of record
,
The New Paradigm of Immunity to Tuberculosis; Contents; 1 Epidemiology of Tuberculosis Immunology; Abstract; 1…Introduction; 1.1 Global Trends in Tuberculosis Epidemiology; 1.2 The Role of Immunological Factors in Global Tuberculosis Epidemiology; 1.3 Sources of Evidence for the Impact of Immunologic Disease Upon Tuberculosis; 1.4 Key Epidemiological Terms; 1.5 Immunological Impairment and the Natural History of Tuberculosis; 1.6 Methods of this Review; 2…Specific Immunologic Factors Associated with Tuberculosis; 2.1 Malnutrition; 2.1.1 The Global Burden of Malnutrition
,
2.1.2 The Mechanism for Malnutrition and Susceptibility to Tuberculosis2.1.3 Malnutrition and the Risk of Tuberculosis; 2.1.4 Vitamin Deficiency and Tuberculosis; 2.1.5 Malnutrition and Tuberculosis Mortality; 2.1.6 The Impact of Malnutrition Upon Tuberculosis at a Population Level; 2.2 Diabetes and Tuberculosis; 2.2.1 The Global Burden of Diabetes; 2.2.2 Diabetes and Risk of Tuberculosis; 2.2.3 Does the Adequacy of Diabetic Control Affect Tuberculosis Susceptibility?; 2.2.4 Diabetes and Treatment Outcomes of Tuberculosis; 2.2.5 The Impact of Diabetes Upon Tuberculosis at a Population Level
,
2.3 HIV and Tuberculosis2.3.1 The Global Burden of HIV; 2.3.2 The Mechanism for HIV Infection and Susceptibility to Tuberculosis; 2.3.3 HIV and Progression to Tuberculosis Disease; 2.3.4 HIV and Susceptibility to LTBI; 2.3.5 Mortality of HIV/Tuberculosis Co-infection; 2.3.6 The Impact of HIV Upon Tuberculosis at a Population Level; 2.4 Aging and Tuberculosis; 2.4.1 Global Trends in Aging; 2.4.2 The Impact of Age Upon Immune Function; 2.4.3 The Impact of Aging Upon the Epidemiology of Tuberculosis; 2.4.4 The Impact of Aging Upon Tuberculosis Infection, Reactivation and Mortality
,
2.4.5 Malnutrition in the Elderly2.4.6 The Impact of Aging on Global Tuberculosis Incidence; 2.5 Smoking, Indoor Air Pollution, and Tuberculosis; 2.5.1 The Global Burden of Smoking and Indoor Air Pollution; 2.5.2 The Impacts of Smoke Exposure Upon Immune Function; 2.5.3 Smoking and Susceptibility to LTBI; 2.5.4 Associations Between Smoking and Tuberculosis; 2.5.5 Smoking and Tuberculosis Mortality; 2.5.6 Indoor Air Pollution and Tuberculosis; 2.5.7 Passive Smoking and Tuberculosis; 2.5.8 The Impact of Smoking and Indoor Air Pollution Upon TB at a Population Level; 2.6 Alcohol and Tuberculosis
,
2.6.1 The Global Burden of Alcohol Use2.6.2 The Impact of Alcohol on Immune Function; 2.6.3 The Impact of Alcohol on Tuberculosis Risk; 2.6.4 The Population Impact of Immunological Impairment Due to Alcohol on Tuberculosis; 2.7 Chronic Disease and Tuberculosis; 2.7.1 The Epidemiology of Chronic Disease; 2.7.2 The Impact of Chronic Illness Upon Tuberculosis Epidemiology; 3…Conclusion; References; 2 Host--Pathogen Specificity in Tuberculosis; Abstract; 1…Introduction; 2…Mycobacterial Strain Specificity in Host Response Phenotypes
,
3…Mycobacterial Strain Specificity in the Genetic Control of Infection and Disease
Additional Edition:
ISBN 9781461461104
Additional Edition:
Buchausg. u.d.T. The new paradigm of immunity to tuberculosis New York, NY : Springer, 2013 ISBN 9781461461111
Additional Edition:
ISBN 9781461461104
Language:
English
Subjects:
Medicine
Keywords:
Tuberkulose
;
Immunität
;
Aufsatzsammlung
DOI:
10.1007/978-1-4614-6111-1
URL:
Volltext
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