Format:
Online-Ressource (X, 454p, digital)
ISBN:
9783642145414
Series Statement:
Handbook of Experimental Pharmacology 201
Content:
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Content:
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies
Note:
Description based upon print version of record
,
Drug Transporters; Preface; Contents; Contributors; Uptake Transporters of the Human OATP Family; In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy; Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy; Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition; The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation
,
P-glycoprotein: Tissue Distribution, Substrates, and Functional Consequences of Genetic VariationsImportance of P-glycoprotein for Drug-Drug Interactions; Multidrug Resistance Proteins (MRPs, ABCCs): Importance for Pathophysiology and Drug Therapy; In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2); Molecular Mechanisms of Drug Transporter Regulation; In Vivo Probes of Drug Transport: Commonly Used Probe Drugs to Assess Function of Intestinal P-glycoprotein (ABCB1) in Humans; Index;
Additional Edition:
ISBN 9783642145407
Additional Edition:
Buchausg. u.d.T. Handbook of experimental pharmacology ; 201: Drug transporters Berlin : Springer, 2011 ISBN 9783642145407
Language:
English
Subjects:
Medicine
Keywords:
Pharmakokinetik
;
Carrier-Proteine
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-14541-4
URL:
Volltext
(lizenzpflichtig)
Author information:
Fromm, Martin Friedrich 1965-
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