Format:
Online-Ressource (digital)
ISBN:
9783764383732
Series Statement:
SpringerLink
Content:
" The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual ""idiotypic"" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the ""Eigenbehavior"" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality. "
Note:
Includes bibliographical references and index
,
Autobiographical note; Realism, constructivism, and the naiveté of the experimental scientist; Beyond underdeterminism: Popper, Kuhn, et al.; The anthropology of science: Ludwik Fleck et al.; The science wars; The immune system, pre-network paradigms; The necessity for an interactive theory of immunity; Proto-ideas of the network theory: antibody self-regulation, idiotypy, the brain analogy, and cybernetics; The idiotypic network theory; The T cell receptor puzzle; Suppression turned idiotypic; Network mannerism; Post-network immunology: Idiotypic network continues at the bedside; Hindsight
,
The fictional nature of scientific notionsFiction turned fact: The case of antibodies; The enticing network: Fiction forever; Logic and laws in life science
Additional Edition:
ISBN 9783764383725
Additional Edition:
Buchausg. u.d.T. Eichmann, Klaus, 1938 - The network collective Basel : Birkhäuser, 2008 ISBN 9783764383725
Language:
English
Subjects:
Mathematics
Keywords:
Immunsystem
;
Idiotyp
;
Antikörper
;
Immunsystem
;
Idiotyp
;
Antikörper
DOI:
10.1007/978-3-7643-8373-2
URL:
Volltext
(lizenzpflichtig)
Author information:
Eichmann, Klaus 1939-
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