Format:
Online-Ressource
Edition:
Karger eBooks Collection 1997-2009
ISBN:
9783805583862
Series Statement:
Endocrine development 12
Content:
It is now clear that abnormal pancreas development can give rise to specific forms of diabetes. Thus, the study of human and animal pancreatic developmental biology, one of the main focuses of the current volume of 'Endocrine Development', is crucial – also in order to define new treatments for diabetes based on cell therapy or regenerative medicine.This publication presents in vivo and in vitro techniques to investigate pancreas development and islet cell function. Besides, a series of reviews are included dealing with genetics. Amongst others, the transcription factors in pancreatic development are observed, and the distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth are studied in detail. A further point under discussion is genomic imprinting and its impact on the pancreas. Special emphasis is placed on the investigation, management and treatment of neonatal diabetes.This collection written by outstanding scientists and clinicians is a valuable reference for endocrinologists, geneticists and pancreatic developmental scientists alike
Note:
Includes bibliographical references and indexes
,
""Cover""; ""Contents""; ""Preface""; ""Pancreatic Development as a Basis for the Definition of New Therapies for Diabetes""; ""Abstract""; ""Pancreatic Development""; ""Beta-Cell Production from Different Tissue Sources""; ""Xenotransplantation as a Source of New Beta-Cells""; ""Beta-Cell Generation by Transdifferentiation""; ""Beta-Cell Development from ES Cells""; ""Conclusion""; ""Acknowledgements""; ""References""; ""Overview of Neonatal Diabetes""; ""Abstract""; ""Transient Neonatal Diabetes""; ""Chromosome 6q Anomalies (OMIM 601410)""; ""The Islet KATP Channel""
,
""KCNJ11 Transient Neonatal Diabetes (OMIM 610582)""""ABCC8 Transient Neonatal Diabetes (OMIM 610374)""; ""Permanent Neonatal Diabetes""; ""Defects in Beta-Cell Transcription Genes""; ""Insulin Promoter Factor 1 Deficiency (OMIM 260370)""; ""GLIS Family Zinc Finger Protein 3 (OMIM 610192)""; ""Permanent Neonatal Diabetes with Cerebellar Hypoplasia (OMIM 609069)""; ""Hepatic Nuclear Factor 1Beta""; ""Defects in Beta-Cell Function""; ""KCNJ11 Permanent Neonatal Diabetes (OMIM 600937)""; ""ABCC8 Mutation Permanent Neonatal Diabetes (OMIM 600509)""
,
""Homozygous Glucokinase Mutations (OMIM 138079)""""Neonatal Diabetes due to Beta-Cell Destruction""; ""Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (FOXP3 and CD25 Mutations) (OMIM 304790)""; ""Wolcott-Rallison Syndrome (OMIM 226980)""; ""Conclusions""; ""References""; ""Transcription Factors in Pancreatic Development""; ""Animal Models""; ""Abstract""; ""Pancreas Specification and Growth""; ""Endocrine Cell Fate Commitment""; ""Specification of the Different Islet Endocrine Cell Types""; ""From Developmental Biology towards a Cell Therapy for Diabetes""
,
""Acknowledgments""""References""; ""Distinct Roles of HNF1Beta, HNF1Alpha, and HNF4Alpha in Regulating Pancreas Development, Beta-Cell Function and Growth""; ""Abstract""; ""The Maturity-Onset Diabetes of the Young Type 5 Gene Product HNF1Beta (TCF2) Regulates Pancreas Specification, Morphogenesis, and Differentiation""; ""The Maturity-Onset Diabetes of the Young Type 3 Gene Product HNF1Alpha (TCF1) Regulates Differentiated Beta-Cell Functions""; ""Regulation of Beta-Cell Growth by HNF1Alpha""
,
""The Maturity-Onset Diabetes of the Young Type 1 Gene Product HNF4Alpha Regulates Beta-Cell Function and Growth""""Concluding Remarks""; ""Acknowledgements""; ""References""; ""In vivo and in vitro Techniques to Study Pancreas Development and Islet Cell Function""; ""Abstract""; ""Methods""; ""In vivo Techniques""; ""Generation of Knockout Mice""; ""In vitro Techniques""; ""Animals""; ""Dissection of Pancreatic Rudiments""; ""Organ Culture""; ""Analysis of the Tissues by Immunohistochemistry""; ""In situ Hybridization""; ""Results and Discussion""
,
""Analysis of the Pancreatic Development in FGF10 Knockout Mice""
Additional Edition:
ISBN 9783805583855
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Neugeborenenkrankheit
;
Diabetes mellitus
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