In:
Respiration, S. Karger AG, Vol. 93, No. 5 ( 2017), p. 301-310
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Various exercise training programs are used for patients with chronic obstructive pulmonary disease (COPD) of different severity. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To investigate the impact of individualized high-intensity training on exercise capacity with COPD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 49 patients agreed to participate. Of these, 31 were assigned to the training group and 18 served as controls. The training group exercised twice a week for 90 min with consecutively increasing loads. At the time of enrollment (T 〈 sub 〉 0 〈 /sub 〉 ), as well as after 3 (T 〈 sub 〉 1 〈 /sub 〉 ) and 6 (T 〈 sub 〉 2 〈 /sub 〉 ) months, a 6-min walk test (6-MWT) was performed and data on health-related quality of life, femoral muscle thickness, and various serum markers were obtained. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The training group improved in their 6-MWT results (T 〈 sub 〉 0 〈 /sub 〉 = 407 ± 152 m vs. T 〈 sub 〉 1 〈 /sub 〉 = 459 ± 127 m, 〈 i 〉 p 〈 /i 〉 = 0.002, vs. T 〈 sub 〉 2 〈 /sub 〉 = 483.2 ± 130.1 m, 〈 i 〉 p 〈 /i 〉 = 0.004), in their cross-sectional area of the musculus rectus femoris (T 〈 sub 〉 0 〈 /sub 〉 = 6.2 ± 1.2 cm 〈 sup 〉 2 〈 /sup 〉 vs. T 〈 sub 〉 1 〈 /sub 〉 = 6.9 ± 1.2 cm 〈 sup 〉 2 〈 /sup 〉 , 〈 i 〉 p 〈 /i 〉 = 0.003, vs. 7.5 ± 1.6 cm 〈 sup 〉 2 〈 /sup 〉 , 〈 i 〉 p 〈 /i 〉 = 0.002), and in their St. George's Respiratory Questionnaire (SGRQ) score (T 〈 sub 〉 0 〈 /sub 〉 = 43.3 ± 18.0 vs. T 〈 sub 〉 1 〈 /sub 〉 = 36.0 ± 18.4, 〈 i 〉 p 〈 /i 〉 = 0.001, vs. T 〈 sub 〉 2 〈 /sub 〉 = 34.7 ± 18. 0, 〈 i 〉 p 〈 /i 〉 = 0.004). Serum levels of myostatin, irisin, resistin, and α-Klotho did not change significantly within the training period. Of note, the exercise group showed an inverse relationship between serum levels of resistin and those of α-Klotho after 6 months ( 〈 i 〉 r 〈 /i 〉 = -0.608, 〈 i 〉 p 〈 /i 〉 = 0.021). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 COPD patients undergoing an individualized, structured, high-intensity training program improved their exercise capacity, gained muscle mass, and improved their quality of life.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1464419-8
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