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  • 1
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Springer
    UID:
    b3kat_BV048456744
    Format: 1 Online-Ressource (XXV, 856 p. 12 illus., 9 illus. in color)
    Edition: 1st ed. 2022
    ISBN: 9783031049989
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-04997-2
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-04999-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-05000-8
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Cover
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Cham : Springer
    UID:
    b3kat_BV047636155
    Format: 1 Online-Ressource (x, 233 Seiten) , Illustrationen
    ISBN: 9783030826352
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-82634-5
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-82636-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-82637-6
    Language: English
    Subjects: Computer Science
    RVK:
    RVK:
    Keywords: Python ; Augenfolgebewegung ; Blickverhalten
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 3
    UID:
    b3kat_BV036107924
    Format: XX, 387 S. , Ill., graph. Darst.
    ISBN: 9783642049279
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Small RNA ; Transkription ; Biochemische Analyse ; Small RNA ; Genexpression ; Methode
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  • 4
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg
    UID:
    gbv_632395850
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
    ISBN: 9783642049286
    Content: This book provides comprehensive descriptions of the innovative strategies and methodologies for detecting miRNA expression, their application in miRNA research and their potential as tools for clinical diagnosis and prognosis. It begins with the introduction of the overall concept and strategies of miRNA expression detection methods emphasizing the need of a wide variety of these methods to suit specific requirements for research and clinical examination in laboratories. In the following, each single chapter focuses on an independent, unique method of miRNA detection and is divided into five subsections: summary, introduction, protocol (including materials, instrument, reagent, and procedure), application and limitation, and reference. The development of the technique, the ideas behind it and the mechanisms underlying the method are given in the introduction of each chapter. The step-by-step protocols are detailed in the protocol section. Then, the applications and limitations of the methods are discussed. Finally, the literature citations are listed in reference section. Schematic diagrams are included where needed and appropriate for better illustrating the principle of the methodologies. In addition, flowcharts are also provided to outline the protocols for each of the miRNA expression detection methods. This book is aimed to target both researchers involved in miRNA research of any fields in universities and research institutions and medical practitioners who are interested in developing or utilizing miRNA profiling as a complementary and an alternative strategy for clinical diagnosis of human disease.
    Note: Includes bibliographical references and index , 188945_1_En_BookFrontmatter_OnLinePDF; 188945_1_En_1_Part_OnLinePDF; 188945_1_En_1_Chapter_OnLinePDF; 188945_1_En_2_Part_OnLinePDF; 188945_1_En_2_Chapter_OnLinePDF; 188945_1_En_3_Part_OnLinePDF; 188945_1_En_3_Chapter_OnLinePDF; 188945_1_En_4_Part_OnLinePDF; 188945_1_En_4_Chapter_OnLinePDF; 188945_1_En_5_Part_OnLinePDF; 188945_1_En_5_Chapter_OnLinePDF; 188945_1_En_6_Chapter_OnLinePDF; 188945_1_En_7_Chapter_OnLinePDF; 188945_1_En_8_Chapter_OnLinePDF; 188945_1_En_9_Chapter_OnLinePDF; 188945_1_En_6_Part_OnLinePDF; 188945_1_En_10_Chapter_OnLinePDF; 188945_1_En_7_Part_OnLinePDF , 188945_1_En_11_Chapter_OnLinePDF188945_1_En_12_Chapter_OnLinePDF; 188945_1_En_13_Chapter_OnLinePDF; 188945_1_En_14_Chapter_OnLinePDF; 188945_1_En_8_Part_OnLinePDF; 188945_1_En_15_Chapter_OnLinePDF; 188945_1_En_16_Chapter_OnLinePDF; 188945_1_En_17_Chapter_OnLinePDF; 188945_1_En_18_Chapter_OnLinePDF; 188945_1_En_19_Chapter_OnLinePDF; 188945_1_En_20_Chapter_OnLinePDF; 188945_1_En_21_Chapter_OnLinePDF; 188945_1_En_22_Chapter_OnLinePDF; 188945_1_En_23_Chapter_OnLinePDF; 188945_1_En_24_Chapter_OnLinePDF; 188945_1_En_25_Chapter_OnLinePDF; 188945_1_En_26_Chapter_OnLinePDF , 188945_1_En_9_Part_OnLinePDF188945_1_En_27_Chapter_OnLinePDF; 188945_1_En_28_Chapter_OnLinePDF; 188945_1_En_29_Chapter_OnLinePDF; 188945_1_En_10_Part_OnLinePDF; 188945_1_En_30_Chapter_OnLinePDF; 188945_1_En_31_Chapter_OnLinePDF; 188945_1_En_32_Chapter_OnLinePDF; 188945_1_En_11_Part_OnLinePDF; 188945_1_En_33_Chapter_OnLinePDF; Wang_Index_o; Wang_Index_o.pdf , Electronic reproduction; Available via World Wide Web
    Additional Edition: ISBN 9783642049279
    Additional Edition: Buchausg. u.d.T. Wang, Zhiguo MicroRNA expression detection methods Berlin : Springer, 2010 ISBN 9783642049279
    Additional Edition: ISBN 3642049273
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Small RNA ; Transkription ; Biochemische Analyse ; Small RNA ; Transkription ; Biochemische Analyse ; Genexpression ; Methode ; Small RNA ; Transkription ; Biochemische Analyse ; Small RNA ; Genexpression ; Methode
    URL: Volltext  (lizenzpflichtig)
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  • 5
    Book
    Book
    Berlin [u.a.] : Springer-Verlag
    UID:
    kobvindex_ZLB15071228
    Format: XII, 193 Seiten , graph. Darst.
    ISBN: 9783642004889
    Note: Text engl.
    Language: English
    Keywords: RNS-Interferenz ; Gentherapie
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  • 6
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg
    UID:
    gbv_1648253385
    Format: Online-Ressource (digital)
    ISBN: 9783642004896
    Series Statement: SpringerLink
    Content: MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, RD and clinical therapy.
    Note: Includes bibliographical references and index
    Additional Edition: ISBN 9783642004889
    Additional Edition: Buchausg. u.d.T. Wang, Zhiguo MicroRNA interference technologies Berlin : Springer, 2009 ISBN 9783642004889
    Language: English
    Subjects: Biology
    RVK:
    Keywords: RNS-Interferenz ; Gentherapie ; RNS-Interferenz ; Gentherapie
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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