UID:
almahu_9949697705302882
Format:
1 online resource (897 p.)
Edition:
2nd ed. / edited by Yehuda Shoenfeld, M.Eric Gershwin, Pier-Luigi Meroni.
ISBN:
1-280-72930-9
,
9786610729302
,
0-08-046723-7
Content:
Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, di
Note:
Previous ed.: 1996.
,
Front Cover; Title Page; Copyright Page; Table of Contents; Foreword; Preface; About the Editors; List of Contributors; Introduction; Part I Introduction: Autoantibodies-Unique Characteristics; Chapter 1 What is an Autoantibody?; Abstract; Introduction; Characterization of autoimmune diseases; Tolerance; Concluding remarks; References; Chapter 2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity; Abstract; Historical notes; The origin of NAbs; NAbs and autoimmunity; NAbs and the innate immune system; Apoptosis and NAbs; Protective NAbs; References
,
Chapter 3 Molecular MimicryAbstract; Historical notes; Forms of molecular mimicry; Natural autoantibodies and molecular mimicry; Animal model of molecular mimicry; Clinical utility; Conclusion; References; Chapter 4 Affinity and Avidity of Autoantibodies; Abstract; Historical notes; Avidity and affinity; Clinical utility in autoimmune disorders; Take-home messages; References; Chapter 5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies; Abstract; Introduction; Cell surface binding and lysis (cytotoxicity); Binding to cell surface receptors without cytolysis
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Immune complex-mediated damageTranslocation of intracellular antigens to cell membrane; Penetration into living cells; Binding to extracellular molecules; Take-home messages; References; Chapter 6 Native Autoantigens Versus Recombinant Autoantigens; Abstract; Introduction; Detection of autoantibodies; ELISA; Native autoantigens; Recombinant autoantigens; Criteria for usage of autoantigens in immunoassays; Limitations of recombinant technology for the production of autoantigens; Acknowledgements; Take-home messages; References; Chapter 7 Redox-Reactive Autoantibodies; Abstract
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Historical notesAutoantigens; Autoantibodies; Acknowledgements; Take-home messages; References; Chapter 8 Predictive Autoantibodies; Abstract; Introduction; Prediction of disease; Prediction of specific clinical manifestations; Hierarchy of autoantibodies; Combining HLA and predictive antibodies in prediction; Combining specific genes and antibody testing; Implications and future directions; Take-home messages; References; Chapter 9 Autoantibody Subclasses; Abstract; Historical notes; The findings; The methods; The causes; The consequences; Conclusion; References
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Chapter 10 Idiotypes and Anti-IdiotypesAbstract; Historical notes; The autoantigen(s); Structure of idiotypes; Genetics; Autoantibodies; Physiologic role; Pathogenic role; Clinical utility; Summary; Take-home messages; References; Chapter 11 Novel Diagnostic Methods for Autoantibody Detection; Abstract; The use of single autoantibody tests in the diagnosis and classification of autoimmune diseases: The 'old' technologies; Multiplex technologies for the study of autoantibody profiles: The 'new' technologies; The predictive role of autoantibody profiles; Take-home messages; References
,
Part II Allergic Disease Autoantibodies
,
English
Additional Edition:
ISBN 0-444-52763-X
Language:
English
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