Format:
XII + 190 S
Edition:
Online-Ausg. Online-Ressource Karger eBooks Collection 1997-2009
ISBN:
3805578628
Series Statement:
Chemical immunology and allergy 86
Content:
Epithelial defense against infectious agents relies on the recognition of microbial products by pattern recognition receptors and the local production of antimicrobial peptides. This book provides a state-of-the-art overview of the basic characteristics and clinical relevance of antimicrobial peptides, with special emphasis on their role in skin, intestinal and lung inflammation. The evolutionary significance of antimicrobial peptides is highlighted by an in-depth analysis of their structure, activity and gene regulation in 〈i〉Drosophila melanogaster〈/i〉. Toll-like receptors are an important class of pattern recognition receptors, whose roles in recognizing bacterial molecular patterns and in the intracellular signalling pathways involved in the differentiation and function of dendritic cells are discussed. Finally, this book also addresses the role of intraepithelial lympho cytes in epithelial defense, notably of gammadelta T cells which form a link between innate and adaptive immune responses. The combined analysis of epithelial and lymphoid cells and effector mechanisms sheds new light on the epithelial defense system in physiological and pathophysiological conditions. Immunologists, dermatologists, microbiologists, and infectious disease specialists will greatly benefit from the wealth of new findings presented by leading investigators
Note:
Includes bibliographical references (p.174-183) and index
,
Cover; Contents; Preface; Antimicrobial Peptides: Basic Features and Clinical Relevance; Reciprocal Interactions of Host Cells and Microbes; Contribution of T Cells to Epithelial Defense; Author Index; Subject Index
,
Cover; Contents; Preface; Antimicrobial Peptides: Basic Features and Clinical Relevance; Reciprocal Interactions of Host Cells and Microbes; Contribution of T Cells to Epithelial Defense; Author Index; Subject Index
Additional Edition:
ISBN 9783318011746
Additional Edition:
ISBN 9783805578622
Additional Edition:
Print version Mechanisms of Epithelial Defense
Language:
English
DOI:
10.1159/isbn.978-3-318-01174-6
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