Format:
Online-Ressource (XVIII, 608 p)
,
online resource
Edition:
Springer eBook Collection. Biomedical and Life Sciences
ISBN:
9781402022319
Content:
The population of the Indian subcontinent consists of a fine amalgamation of people from diverse tribal, cultural, religious and social backgrounds. Mortality and morbidity from a vast number of medical and surgical conditions is significant and well above compared to the developed countries. Although a large component of the human health problem is related to infection, malnutrition and other preventable causes, a significant proportion is linked to hereditary factors reflecting in the form of chromosomal, single gene and complex medical diseases. Unusual and unique Mendelian disorders are not uncommon and a number of common medical conditions, such as ischemic heart disease and diabetes mellitus are relatively more prevalent among those living in the developing countries of the Indian subcontinent and as well as among the migrant population groups in the western world. However, true burden of the inherited disorders among the Asian Indians is not known, and probably underestimated. This text includes a detailed and concise account of the social and cultural diversity, medical demography, genetic epidemiology, consanguinity and common genetic disorders affecting people from the Indian subcontinent. In addition, specific issues of genetic services in various regions are addressed
Note:
Section A: Human Genetics and the Indian Subcontinent1. The Indian subcontinent and human genetics: An introduction -- 2. Ethnic and cultural diversity -- 3. Genomic and gene diversity -- 4. Epidemiology of genetic diseases -- 5. Immunogenetic basis of variation and disease susceptibility -- 6. Consanguinity: cultural, religious and social aspects -- Section B: Selected Genetic Disorders -- 7. Congenital developmental anomalies -- 8. Malformation syndromes in India -- 9. Down syndrome in India -- 10. Inherited metabolic diseases among South Asians in the United Kingdom -- 11. Management of inherited metabolic diseases in India -- 12. Indian childhood cirrhosis and other metabolic liver diseases -- 13. Thalassaemias and other haemoglobinopathies -- 14. Disorders of haemostasis and thrombosis -- 15. Glucose-6-phosphate dehydrogenase deficiency and other inherited red cell defects -- 16. Genetic neurological and psychiatric diseases -- 17. Inherited skeletal dysplasias and collagen diseases -- 18. Deafness and related syndromes -- 19. Genetic diseases of the eye in India -- 20. The genetics of cancer: the Indian subcontinent perspective -- 21. Diabetes mellitus and related disorders -- 22. Coronary heart disease and related diseases -- 23. Diseases of the kidney: clinical spectrum and genetics -- 24. The genetics of resistance to malaria -- Section C: Indian Subcontinent and Genetic Services -- 25. Genetic disorders and medical genetics in India -- 26. Genetic disorders and medical genetics in Sri Lanka -- 27. Genetic counselling for families from the Indian subcontinent -- 28. Ethical issues in clinical genetics and the Indian subcontinent.
Additional Edition:
ISBN 9789048162628
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9789048162628
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9781402012150
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9789401570053
Language:
English
DOI:
10.1007/978-1-4020-2231-9
URL:
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