Format:
Online-Ressource (XXVIII, 447 p. 88 illus., 80 illus. in color, online resource)
ISBN:
9783709114193
Series Statement:
SpringerLink
Content:
This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer
Note:
Description based upon print version of record
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Preface; Contents; Contributors; Part I:Molecular Vaccines - From Prophylaxis to Therapy; 1: From Pasteur to Personalized Vaccines; 1.1 1885: The First Therapeutical Vaccine; 1.2 Systems Vaccinology; 1.3 Biomarkers: Correlates of Protection; 1.4 P-Vaccines: From Bench to Bedside; 1.5 Therapeutical Window; References; Part II:Vaccine Immunology; Overview of Part II; 2: Basic Vaccine Immunology; 2.1 Chemical Nature of Antigens; 2.2 Antigen-Presenting Cells; 2.2.1 Capture of Topically Applied Antigens by Langerhans Cells; 2.2.2 Capture of Antigens by Dendritic Cells; Box 2.1
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2.3 Inflammation and CytokinesBox 2.2; 2.4 Therapeutic Vaccines and the Immunosuppressive Environment; 2.5 Pathogen Recognition; 2.5.1 Non-Toll-Like Receptors; 2.5.2 Toll-Like Receptors; 2.6 PAMPs: Pathogen-Associated Molecular Patterns; 2.7 DAMPs: Damage-Associated Molecular Patterns; 2.8 TLR Intracellular Signal Cascade and Immune Response; Box 2.3; 2.9 T Cells and Priming; 2.10 Immune Memory; 2.10.1 Memory T Cells; Box 2.4; 2.10.2 Memory B Cells; 2.11 Immunosenescence and Vaccination; Box 2.5; 2.12 Booster and Vaccination Strategies; References; 3: Gut Immunology and Oral Vaccination
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3.1 Introduction3.2 Vaccine Uptake and Immunological Priming in the Intestinal Mucosa; 3.3 Immunological Effectors Induced by Oral Vaccination; 3.4 Intestinal Tolerance and Immune Regulation Related to Vaccination; 3.5 Licensed Oral Vaccines and Their Performance in Different Populations; 3.5.1 Oral Polio Vaccine; 3.5.2 Rotavirus Vaccines; 3.5.3 Rotarix®; 3.5.4 RotaTeq®; 3.5.5 Cholera Vaccines; 3.5.6 Oral Typhoid Vaccine; 3.6 Barriers Associated with Oral Vaccination; 3.6.1 Small Bowel Bacterial Overgrowth (SBBO) and Environmental Enteropathy; 3.6.2 Malnutrition
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3.6.3 Maternal Antibodies and Immune Components of Maternal Milk3.6.4 Microbiota; 3.6.5 Oral Immunization of Newborns and Coadministration of Vaccines; 3.7 New Oral Vaccines and Approaches for Immunization Against Enteric Pathogens: Typhoid and Paratyphoid Vaccines; 3.7.1 Shigella and Enterotoxigenic E. coli (ETEC) Vaccines; 3.7.2 Norovirus Virus-like Particles; 3.7.3 Novel Adjuvants for Mucosal Immunization; 3.7.4 Improved Immunization Strategies; 3.8 Conclusions and Future Directions; References; 4: Pediatric Immunology and Vaccinology; 4.1 Introduction
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4.2 Cellular Components of Innate and Adaptive Immunity4.3 Neonatal and Childhood Antigen-Presenting Cells; 4.4 Neonatal and Childhood T Cells; 4.5 Neonatal and Childhood B Cells; 4.6 Quality of Antibody Responses in Infants; 4.7 Soluble Factors in Neonatal Blood Affecting Adaptive Immune Responses; 4.8 Current Pediatric Vaccines, Worldwide; 4.9 Vaccine Side Effects; 4.10 Vaccination During Pregnancy; 4.11 Immunization Responses in Children with Primary or Acquired Immunodeficiency; 4.12 Development of New Pediatric Vaccines; References; Part III:Vaccines for Infectious Diseases
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Overview of Part III
Additional Edition:
ISBN 9783709114186
Additional Edition:
Druckausg. Molecular vaccines ; 1: From prophylaxis to therapy Wien, Heidelberg [u.a.] : Springer, 2013 ISBN 9783709114186
Language:
English
DOI:
10.1007/978-3-7091-1419-3
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