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Molecular Insights into the Relationship Between Platelet Activation and Endothelial Dysfunction: Molecular Approaches and Clinical Practice

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Abstract

Platelets are one of the coagulation cells. When platelet activation occurs, many mediators are released and affect endothelial cells (ECs) and lead to endothelial dysfunction (ED). ED plays an important role in the pathogenesis of many diseases, including cardiovascular disease (CVD). Platelet are of important factors in ED. The release of mediators by platelets causes the stimulation of inflammatory pathways, oxidative stress, and apoptosis, which ultimately result in ED.

On the other hand, platelet activation in CVD patients can be associated with a bad prognosis. Platelet activation can increase the level of markers such as p-selectin in the serum. Also, in this study, we have discussed the role of platelet as a diagnostic factor, as well as its use as a treatment option. In addition, we discussed some of the molecular pathways that are used to target platelet activation.

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Data Availability

This is a review study, and it is not an original. Data availability is corresponding author responsibility.

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Acknowledgements

We wish thank you of all our colleague in Iranian Blood Transfusion organization.

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  1. Niloufar Kazemi and Armin Bordbar are first authors.

Authors and Affiliations

  1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran

    Niloufar Kazemi & Hadi Rezaeeyan

  2. Department of Cardiology, Musavi Hospital, School of Medicine, Zanjan University of Medical Science, Zanjan, Iran

    Armin Bordbar

  3. Department of Medical Biochemistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Samaneh Salehipour Bavarsad

  4. Research Committee, Medical School, Arak University of Medical Sciences, Arak, Iran

    Parisa Ghasemi

  5. Islamic Azad University of Najaf Abad, Affiliated Hospitals, Isfahan, Iran

    Maryam Bakhshi

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Kazemi, N., Bordbar, A., Bavarsad, S.S. et al. Molecular Insights into the Relationship Between Platelet Activation and Endothelial Dysfunction: Molecular Approaches and Clinical Practice. Mol Biotechnol 66, 932–947 (2024). https://doi.org/10.1007/s12033-023-01010-8

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