Front Cover; The Effects of Drug Abuse on the Human Nervous System; Copyright; Contents; List of Contributors; Chapter One -Drug Use and Its Consequences; ?1. INTRODUCTION; ?2.1DRUGS AND CONSEQUENCES; ?3. CONCLUSIONS; REFERENCES; Chapter Two -Genetics of Substance Use, Abuse, Cessation, and Addiction: Novel Data Implicate Copy Number Variants; ?1. INTRODUCTION; ?2.1. WORKING HYPOTHESIS I: GENOMIC VARIANTS OF SEVERAL CLASSES AND DIFFERING FREQUENCIES CONTRIBUTE TO VULNERABILITY TO ADDICTI... ?2.2. WORKING HYPOTHESIS II: GENOMIC VARIANTS THAT CONTRIBUTE TO VULNERABILITY TO ADDICTION AND ABILITY TO QUIT PROVIDE LARGELY ...?2.3. WORKING HYPOTHESIS III: MOST GENOMIC VARIANTS THAT CONTRIBUTE TO DEPENDENCE OR ABILITY TO QUIT EXERT EFFECTS OF SMALL SIZE...; ?2.4. WORKING HYPOTHESIS IV: THERE ARE ROBUST OVERALL GENETIC INFLUENCES ON VULNERABILITY TO DEPENDENCE, MANY SHARED ACROSS VULN...; ?3. CONCLUSIONS; REFERENCES; Chapter Three -Epidemiology of Drug Abuse: Building Blocks for Etiologic Research; ?1. INTRODUCTION; ?2.1. EPIDEMIOLOGY; ?2.2. ETIOLOGY; ?3. CONCLUSIONS; ACKNOWLEDGMENTS REFERENCESChapter Four - Detection of Populations At-Risk or Addicted: Screening, Brief Intervention, and Referral to Treatment (SBIRT) in Clinical Settings; ?1. INTRODUCTION; ?2.1. USE OF ALCOHOL; ?2.2. SUBSTANCE ABUSE; ?2.3. PREVENTION AND INTERVENTION; ?3. CONCLUSIONS; REFERENCES; Chapter Five -Cocaine: Mechanism and Effects in the Human Brain; ?1. INTRODUCTION; ?2.1. COCAINE USE IN HUMANS; ?2.2. IMAGING COCAINE ABUSE IN THE HUMAN BRAIN; ?2.3. IMAGING COCAINE: BEHAVIORAL CORRELATES; ?2.4. DOPAMINE TRANSMISSION IN STRIATAL SUBDIVISIONS; ?3. CONCLUSIONS; REFERENCES Chapter Six - Stress, Anxiety, and Cocaine Abuse?1. INTRODUCTION; ?2.1. NEUROTRANSMITTER SYSTEMS IN COCAINE WITHDRAWAL-INDUCED ANXIETY AND STRESS-INDUCED RELAPSE; ?2.2. SEROTONIN; ?2.3. CORTICOTROPIN RELEASING FACTOR; ?2.4. NOREPINEPHRINE; ?2.5. ENDOGENOUS OPIOIDS; ?2.6. OTHER NEUROPEPTIDES; ?3. CONCLUSIONS; REFERENCES; Chapter Seven -The Neuropathology of Drug Abuse; ?1. INTRODUCTION; ?2.1. NEUROBIOLOGICAL BASICS OF DRUG ABUSE; ?2.2. CNS ALTERATIONS OF THE MAJOR DRUGS OF ABUSE; ?2.3. OPIOIDS AND DERIVATIVES; ?2.4. COCAINE; ?2.5. AMPHETAMINES, METHAMPHETAMINE, AND DESIGNER DRUGS ?2.6. AMPHETAMINE AND METHAMPHETAMINE DERIVATIVES?2.7. NEUROPATHOLOGICAL INVESTIGATIONS OF (POLY-) DRUG ABUSERS; ?2.8. NEURODEGENERATION AND DRUGS OF ABUSE; ?3. CONCLUSIONS; REFERENCES; Chapter Eight -The Pathology of Methamphetamine Use in the Human Brain; ?1. INTRODUCTION; ?2.1. DOES METHAMPHETAMINE, A DOPAMINE RELEASER, CAUSE LOSS OF DOPAMINE NEURONAL MARKERS IN HUMAN BRAIN AS OBSERVED IN ANIMAL ST...; ?2.2. NONDOPAMINERGIC CHANGES IN BRAIN OF METHAMPHETAMINE USERS; ?2.3. DOES METHAMPHETAMINE CAUSE OXIDATIVE STRESS IN HUMAN BRAIN? ?2.4. DOES METHAMPHETAMINE CAUSE GLIOSIS (ACTIVATED MICROGLIOSIS AND REACTIVE ASTROGLIOSIS), A REPUTED INDEX OF NEUROTOXICITY, I... | 
