Format:
XXIV, 549 Seiten
,
Illustrationen
ISBN:
9783527333059
,
3527333053
Note:
Literaturangaben
,
A chemist's survey of different antibiotic classes -- Antibacterial discovery: problems and possibilities -- Impact of microbial natural products on antibacterial drug discovery -- Antibiotics and resistance: a fatal attraction -- Fitness costs of antibiotic resistance -- Inhibitors of cell-wall synthesis -- Inhibitors of bacetrial cell partitioning -- The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens -- Bacterial membrane, a key for controlling drug influx and efflux -- Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives -- Recent developments in inhibitors of bacterial type IIA topoisomerases -- Antibiotics targeting bacterial RNA polymerase -- Inhibitors targeting riboswitches and ribozymes -- Targeting ribonuclease P -- Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery -- Aminoacyl-tRNA synthetase inhibitors -- Antibiotics targeting translation initiation in prokaryotes -- Inhibitors of bacterial elongation factor EF-Tu -- Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site -- Reptidyltransferase inhibitors of the bacterial ribosome -- Antibiotics inhibiting the translocation step of protein elongation on the ribosome -- Antibiotics at the ribosomal exit tunnel -- selected structual aspects -- Targeting HSP70 to fight cancer and bad bugs: one and the same battle?
Additional Edition:
9783527659715
Additional Edition:
9783527659708
Additional Edition:
9783527659692
Additional Edition:
9783527659685
Additional Edition:
Online-Ausg. Antibiotics Weinheim : Wiley-VCH, 2014 9783527333059
Additional Edition:
3527333053
Language:
English
Subjects:
Medicine
Keywords:
Antibiotikum
;
Aufsatzsammlung
