Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (1243 p.)

Edition: 1st ed.

ISBN: 1-282-99423-9 , 9786612994234 , 0-12-382033-2

Content: Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on pl

Note: Description based upon print version of record. , Front Cover; Dedication; Reproductive And Developmental Toxicology; Copyright; Contents; Foreword; List of Contributors; Section 1 - General; Chapter 1 - Introduction; Introduction; Chapter 2 - Reproductive anatomy and physiology; Introduction; Important definitions and concepts; Review of normal human reproduction; Concluding remarks and future directions; References; Chapter 3 - Bio-communication between mother and offspring; Introduction; Maternal influences on the development of the offspring; Transportation of bioactive substances between mother and offspring , Concluding remarks and future directionsReferences; Chapter 4 - Pharmacokinetics in pregnancy; Introduction; Factors affecting pharmacokinetics in pregnancy; The fetal compartment; Maternal disease and obstetrical complications; Origins of the knowledge gap; Concluding remarks, current initiatives and future directions; References; Chapter 5 - PBPK models in reproductive and developmental toxicology; Introduction; PBPK Modeling: basic concepts and tools; PBPK Modeling in reproductive and developmental toxicology; PBPK Model applications in reproductive and developmental toxicology , Concluding remarks and future directionsReferences; Chapter 6 - Transfer of drugs and xenobiotics through milk; Introduction; Drug excretion into breast milk; Drug disposition in the infant; Drugs that should be used with caution; Non-medicinal substances; Environmental pollutants; Concluding remarks and future directions; Acknowledgment; References; Section 2 - Safety Evaluation andToxicity Testing Models; Chapter 7 - Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: an FDA perspective; Introduction; Drugs intended for use in humans , Vaccines intended for use in humansDrugs intended for use in animals; References; Chapter 8 - Reproductive and developmental safety evaluation of new pharmaceutical compounds; Introduction; Overview Of Human Pharmaceutical Development Process; Developmental And Reproductive Toxicity (Dart) Studies Needed For Development Of Innovative Human Pharmaceuticals; Interpretation Of Human Risk From The Reproductive And Developmental Toxicity Studies In Animals; Reproductive Risks Communication And Management; Concluding Remarks And Future Directions; References , Chapter 9 - Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicityIntroduction; Choice of animal test models; Non-mammalian animal models; Endpoints of reproductive toxicity; Tests and test guidelines; Types of studies; The path to alternative tests and conclusions; References; Chapter 10 - OECD guidelines and validated methods for in vivo testing of reproductive toxicity; Introduction; Method OECD 414 (prenatal developmental toxicity); Method OECD 415 (One-generation reproduction toxicity study) , Method OECD 416 (two-generation reproduction toxicity study) , English

Additional Edition: ISBN 0-12-382032-4

Language: English

UID:

Format: 1 Online-Ressource (XVIII, 1202 S., [11] Bl.) : , zahlr. Ill., graph. Darst.

Edition: 1. ed.

ISBN: 978-0-12-382032-7 , 978-0-12-382033-4

Language: English

Subjects: Medicine

Keywords: Reproduktionstoxikologie ; Embryotoxizität