UID:
almahu_9948026528402882
Umfang:
1 online resource (459 p.)
Ausgabe:
1st ed.
ISBN:
9786611279608
,
0-08-057032-1
Inhalt:
Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents,
Anmerkung:
Description based upon print version of record.
,
Front Cover; Medicinal Chemistry of Anticancer Drugs; Copyright Page; Preface; Abbreviations; Chapter 1: Introduction; 2. A Brief Account of the Role of Chemistry in Cancer Chemotherapy; 3. Natural Products in Cancer Chemotherapy; 4. A Brief Comment About Cancer Nanotechnology; References; Chapter 2: Antimetabolites; 5. Inhibitors of Dihydrofolate Reductase (DHFR); 9. Antimetabolite Enzymes; Chapter 3: Anticancer Drugs That Inhibit Hormone Action; 1. Introduction; 9. Compounds Acting on Other Proteins of the Nuclear Receptor Superfamily: Retinoids
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Chapter 4: Anticancer Drugs Acting via Radical Species, Photosensitizers and Photodynamic Therapy of Cancer4. Mitoxantrone and Related Quinones; 8. Enediyne Antibiotics; Chapter 5: DNA Alkylating Agents; 3. Aziridines (Ethyleneimines); Chapter 6: Alkylating and Non-Alkylating Compounds Interacting with the DNA Minor Groove; Chapter 7: DNA Intercalators and Topoisomerase Inhibitors; 1. DNA Intercalation and Its Consequences; Chapter 8: Anticancer Drugs Targeting Tubulin and Microtubules; 2. Drugs That Inhibit Microtubule Polymerization at High Concentrations
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Chapter 9: Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation1. Introduction: The Role of Protein Kinases in Cancer; 4. Inhibitors of Serine-Threonine Kinases; 6. Inhibitors of Farnesyldiphosphate Synthase and Geranylgeranyldiphosphate Synthase; Chapter 10: Other Approaches to Targeted Therapy; Chapter 11: Drug Targeting in Anticancer Chemotherapy; 4. Macromolecular Small-Drug Carrier Systems; 5. Polymer-Directed Enzyme Prodrug Therapy (PDEPT); 6. Folate Receptor-Targeted Chemotherapy and Immunotherapy of Cancer
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Chapter 12: Drugs That Modulate Resistance to Antitumor Agents1. ATP-Binding Cassette Efflux Pumps in Anticancer Drug Resistance; References; Chapter 13: Cancer Chemoprevention; 1. Introduction; 2. Ligands for Nuclear Receptors in Cancer Chemoprevention; 3. Anti-Inflammatory Agents and Antioxidants in Cancer Chemoprevention; Index
,
English
Weitere Ausg.:
ISBN 0-444-52824-5
Sprache:
Englisch
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