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  • Brandenburg  (3)
  • MPI Bildungsforschung  (3)
  • Akademie d. Wiss.
  • TH Brandenburg
  • SB Bad Liebenwerda
  • 2010-2014  (3)
  • Licensed  (3)
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  • 1
    Online Resource
    Online Resource
    Advances in Stem Cell Aging (2012)
    Basel [u.a.] : Karger
    Details
    UID:
    gbv_862689104
    Format: 1 Online-Ressource (VIII, 126 S)
    Edition: Karger eBooks Collection
    ISBN: 9783318021707 , 9783318021714
    Series Statement: Else Kröner-Fresenius symposia 3
    Content: Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery
    Note: Up-to-date meeting report of the Else Kröner-Fresenius Symposium on Adult Stem Cell Aging , Speakers at the symposium , Hematopoietic stem cell aging and cancer , DNA damage, checkpoint responses, and cell cycle control in aging stem cells , Hematopoietic stem cell aging and fate decision , Stem cell therapy and stress response in pancreas and intestine ; Sperka, T., Omrani, O. ; Niche-stem cell interations and environmental influences , Stem cells and metabolism , Molecular mechanisms of muscle stem cell aging , Neural stem cells in development and aging
    Additional Edition: ISBN 9783318021707
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783318021707
    Language: English
    Subjects: Biology
    RVK:
    WX 6600
    Keywords: Adulte Stammzelle ; Altern ; Konferenzschrift
    DOI: 10.1159/isbn.978-3-318-02171-4
    URL: lizenzpflichtig
    URL: Volltext
    URL: Inhaltsverzeichnis
    Author information: Rudolph, Karl Lenhard 1969-
    Library Location Call Number Volume/Issue/Year Availability
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    Online Access
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    Stabi Berlin
    UB Potsdam
    MPI Bildungsforschung
  • 2
    Online Resource
    Online Resource
    Methodologie der Sozialwissenschaften : Einführung in Probleme ihrer Theorienbildung und praktischen Anwendung (2014)
    Wiesbaden :Springer Fachmedien Wiesbaden :
    Details
    UID:
    almahu_9947361671102882
    Format: XVII, 280 S. 18 Abb. , online resource.
    Edition: 7., wesentlich überarbeitete Aufl. 2014.
    ISBN: 9783658019112
    Content: Dieses Buch bietet eine elementare, kritische und leicht verständliche Einführung in die zentralen Probleme der Methodologie der Sozialwissenschaften. Dabei wird ein Einblick in die konkrete Arbeitsweise und die Probleme einer modernen empirisch-theoretischen Sozialwissenschaft gegeben.   Der Inhalt Wozu sollte man sich mit Methodologie befassen? Die Vorgehensweise bei Erklärungen und Prognosen Die Methode des Verstehens Wie man Begriffe definiert und beurteilt Der Informationsgehalt sozialwissenschaftlicher Aussagen Probleme der empirischen Prüfung sozialwissenschaftlicher Aussagen Wie kritisiert man eine sozialwissenschaftliche Theorie? Werte in der Wissenschaft Wie man die Sozialwissenschaften zur Lösung praktischer Probleme anwenden kann   Die Zielgruppen Studierende und Lehrende der Sozialwissenschaften Personen, die an den Grundlagenproblemen der Sozialwissenschaften interessiert sind Der Autor Dr. Karl-Dieter Opp ist Professor em. für Soziologie an der Universität Leipzig und "Affiliate" (außerplanmäßiger) Professor an der University of Washington (Seattle). Seine Schwerpunkte in Forschung und Lehre sind soziologische Theorie (insbesondere die Theorie rationalen Handelns), Normen und Institutionen, Methodologie der Sozialwissenschaften, Soziologie des abweichenden Verhaltens und politische Soziologie (insbesondere politische Partizipation).
    Note: Wozu sollte man sich mit Methodologie befassen? -- Die Vorgehensweise bei Erklärungen und Prognosen -- Die Methode des Verstehens -- Wie man Begriffe definiert und beurteilt -- Der Informationsgehalt sozialwissenschaftlicher Aussagen -- Probleme der empirischen Prüfung sozialwissenschaftlicher Aussagen -- Wie kritisiert man eine sozialwissenschaftliche Theorie? -- Werte in der Wissenschaft -- Wie man die Sozialwissenschaften zur Lösung praktischer Probleme anwenden kann.
    In: Springer eBooks
    Additional Edition: Printed edition: ISBN 9783658019105
    Language: German
    Subjects: Sociology
    RVK:
    MR 1100
    RVK:
    MR 2000
    Keywords: Lehrbuch
    DOI: 10.1007/978-3-658-01911-2
    URL: http://dx.doi.org/10.1007/978-3-658-01911-2
    URL: lizenzpflichtig
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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    HU Berlin
    UB Potsdam
    MPI Bildungsforschung
  • 3
    Online Resource
    Online Resource
    Molecular mechanisms of adult stem cell aging : Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging (1st: 2009: Günzburg, Germany) ; 19 tables (2010)
    Freiburg im Breisgau [u.a.] : Karger
    Details
    UID:
    gbv_165204065X
    Format: Online-Ressource (PDF-Datei: VI, 107 S.)
    ISBN: 9783805592444 , 1283153556 , 9781283153553
    Series Statement: Else-Kröner-Fresenius-Symposia 1
    Content: There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology
    Note: A meeting report of the first international Else Kröner-Fresenius-Symposium on Adult Stem Cell Aging , ""Cover""; ""Contents""; ""Preface""; ""Introduction""; ""Chapter 1: Speakers at the Symposium""; ""Thomas Braun, MD""; ""Tao Cheng, MD""; ""James DeGregori, PhD""; ""Gerald de Haan, PhD""; ""Ronald A. DePinho, MD""; ""Kenneth Dorshkind, PhD""; ""Toren Finkel, MD, PhD""; ""Hartmut Geiger, PhD""; ""Margaret A. Goodell, PhD""; ""D. Leanne Jones, PhD""; ""Zhenyu Ju, MD, PhD""; ""Sean J. Morrison, PhD""; ""Hiromitsu Nakauchi, MD, PhD""; ""Andre Nussenzweig, PhD""; ""Thomas A. Rando, MD, PhD""; ""Tannishtha Reya, PhD""; ""Hans-Reimer Rodewald, PhD""; ""Derrick J. Rossi, PhD"" , ""Karl Lenhard Rudolph, MD""""Norman E. Sharpless, MD""; ""Toshio Suda, MD""; ""Andreas Trumpp, PhD""; ""Maarten van Lohuizen, PhD""; ""Gary Van Zant, PhD""; ""Amy J. Wagers, PhD""; ""Irving L. Weissman, MD""; ""Ting Xie, PhD""; ""Chapter 2: Hematopoietic Stem Cell Aging and Fate Decision""; ""Abstract""; ""Characteristics of Hematopoietic Stem Cells""; ""Functional Changes during Aging""; ""Immuno-Phenotype Changes during Aging""; ""Epigenetic Regulation of Stem Cell Function""; ""DNA Damage Signaling in the Regulation ofHSCs"" , ""Dissecting Age-Dependent Effects on Hematopoiesis in Recombinant Inbred Mouse Strains""""Genes Controlling HSC Quiescence and Self-Renewal""; ""Regulation of Dormant HSCs""; ""Summary""; ""References""; ""Chapter 3: Alterations of Systemic Environment Impair Stem Cell Function during Aging ""; ""Abstract""; ""Introduction""; ""Macroenvironmental Alterations Regulate HSC Function""; ""Macroenvironmental Alterations Regulate SMP Function""; ""Macroenvironmental Aging Characterized by Alterations of Circulatory Factors"" , ""DNA Damage and Telomere Dysfunction Induce Age-Dependent Secretion ofv Circulating Factors""""References""; ""Chapter 4: Novel Insights into Regulation of Stem Cell Aging by Aging of the Niche and Alterations in Systemic Factors""; ""Abstract""; ""Aging of Muscle Stem Cells Is Reversible""; ""Hematopoietic Stem Cells Can Be Rejuvenated by Systemic Factors""; ""Adhesion Is Central to Stem Cell Niche Interactions""; ""Drosophila Germ Line Stem Cells and Their Niche""; ""References""; ""Chapter 5: Aging and Hematopoietic Malignancies ""; ""Abstract"" , ""Loss of Proliferative Capacity of Hematopoietic Cells Can Accelerate Leukemogenesis""""Leukemic Cells Evade the Immune System""; ""Patterns of Cell Divisions in Leukemia""; ""References""; ""Chapter 6: Intestinal Stem Cell Aging ""; ""Abstract""; ""Intestinal Epithelium""; ""Intestinal Stem Cells""; ""Molecular Control of Cell Proliferation and Organ Maintenance in the Intestine""; ""Age-Associated Diseases of the Intestine""; ""Mechanisms of Intestinal Stem Cell Aging in Model Systems""; ""Outlook""; ""References""; ""Chapter 7: Molecular Mechanisms of Aging in Muscle Stem Cells "" , ""Abstract""
    Additional Edition: ISBN 9783805592437
    Additional Edition: Erscheint auch als Druck-Ausgabe Molecular mechanisms of adult stem cell aging Basel : Karger, 2010 ISBN 9783805592437
    Language: English
    Subjects: Biology
    RVK:
    WW 8844
    Keywords: Adulte Stammzelle ; Altern ; Telomer ; Konferenzschrift
    URL: lizenzpflichtig
    URL: Volltext
    Author information: Rudolph, Karl Lenhard 1969-
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
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    Stabi Berlin
    UB Potsdam
    MPI Bildungsforschung
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