Format:
Online-Ressource
ISSN:
1437-2096
Content:
Herein, a general strategy for the regioselective dearomative 1,2-hydrocyanoalkylation of chromium-bound (hetero) arenes with simple alkylnitriles as pronucleophiles was disclosed, providing rapid access to 1,3-cyclohexadienes possessing useful alkylnitrile groups. The versatility of this methodology further enabled a selective dearomative deuteration reaction. Finally, synthetic applications of the method in the formal synthesis of natural products, including erysotramidine, demethoxyerythratidinone, and morphine, were demonstrated.
In:
day:06
In:
month:11
In:
year:2023
In:
Synlett, Stuttgart [u.a.] : Thieme, 1989-, (06.11.2023), 1437-2096
Language:
English
URN:
urn:nbn:de:101:1-2023122111052881408330
URL:
https://doi.org/10.1055/a-2185-0581
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023122111052881408330
URL:
https://d-nb.info/1314284061/34
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