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  • BSZ  (100)
  • English  (100)
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  • 1
    Online Resource
    Online Resource
    Liver fibrosis and regeneration in dogs and cats: An immunohistochemical approach (2008)
    [Erscheinungsort nicht ermittelbar] : Utrecht University
    Details
    UID:
    (DE-627)1803156953
    Content: In this thesis we focus on liver tissue repair processes in canine and feline hepatitis, on formalin fixed paraffin embedded archival liver specimens. Hepatitis was diagnosed using histological standard criteria, and always includes hepatocellular cell death and an inflammatory infiltrate. Subsequently, the liver may react with regeneration and fibrosis (a detectable deposit of extracellular matrix). Fibrosis can develop into cirrhosis, which has a poor prognosis. Based on a better understanding of the underlying reaction pattern of hepatic tissue repair we hope to facilitate the development of new anti-fibrotic therapies. Moreover, the liver is a very interesting model organ for tissue repair in general. In contrast to most other organs, disease progress and associated tissue repair attempts can be monitored relatively easily. This study contains the first identification of a liver progenitor cell compartment in the dog and cat, comparable to human liver. Several key cell types regarding hepatic fibrosis and regeneration were identified immunohistochemically: hepatocytes, cholangiocytes, fibroblasts including hepatic stellate cells (HSCs) and progenitor cells. Also, immunohistochemical localization of major signaling factors determining the outcome of hepatic tissue repair were investigated: hepatocyte growth factor (HGF), HGF receptor (c-Met) and TGF-beta-receptor1 (TGF-β-R1) as occurring in spontaneous canine hepatitis. These findings were compared to previously determined associated messenger-RNA (mRNA) and protein expression levels. Remarkably, the absolute HGF availability did not seem the limiting factor in hepatic regeneration. In acute hepatitis, hepatic stellate cell upregulation of HGF was restricted to locations adjacent to necrotic areas. All proliferating progenitor cells (reactive ductules) showed mitogenic stimulation, but could be restrained from further differentiation by TGF-beta signaling from encompassing TGF-β-R1 positive cells. Interface locations of chronic hepatitis (CH) showed highest activity of the inflammatory process During fibrosis, the extracellular matrix (ECM) increases in volume. We studied the distribution of the ECM protein tenascin-C (TN-C). TN-C distribution in CH matched the distribution of the active interface phenotype. Possibly, TN-C staining combined with α-SMA could be useful to assess the type or activity of the fibrosing process, and HSC activation, respectively. At sites (as seen in CH) with enhanced ECM turnover, the disease process is active, with generally a poorer prognosis when widely present. However, we expect that this activity also implies potential reversibility of fibrosis, thus an indication of fibrosis activity may predict potential therapeutical accessibility and success rate. To optimize the use of a single liver biopsy and to minimize the number of biopsies per animal we evaluated different fixation- and RNA isolation methods available in our laboratory. Conclusively, we found that at least two biopsies are needed. One for histology (formalin 1-4 hrs) and one for molecular assays: RNA-later. A logical next step will be the further identification of relations between all relevant cells and their microenvironment: the cellular niche consisting of the surrounding cells, matrix and signaling factors. The cellular niche likely plays a decisive role in the fate of cells. Development of markers to assess the potential of scar regression in patients justifies great interest as scar regression potentially means clinical improvement in currently untreatable diseases like liver cirrhosis.
    Note: Dissertation Utrecht University 2008
    Language: English
    URL: kostenfrei
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    Online Resource
    BSZ
    GBV
  • 2
    Book
    Book
    Mass media campaigns to promote safe sex : an evaluation of public campaigns in the Netherlands (1999)
    [Amsterdam] : Kurt Lewin Inst.
    Details
    UID:
    (DE-627)161525000X
    Format: 141 S. , Ill.
    ISBN: 9076269122
    Series Statement: Dissertatiereeks / Kurt Lewin Instituut 1999,10
    Note: Zsfassung in niederländ. Sprache , Zugl.: Groningen, Univ., Diss., 1999
    Language: English
    Keywords: Massenmedien ; Psychologie ; Safer Sex ; Aufklärungskampagne ; Forschungsbericht ; Hochschulschrift
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    Book
    BSZ
  • 3
    Book
    Book
    Zeki Faik İzer (1995)
    Ankara : ENLEM 80
    Details
    UID:
    (DE-627)1135983925
    Format: 191 , überwiegend Ill.
    Edition: 1. baskı
    ISBN: 9757693073
    Series Statement: ENLEM 80 yayınları 4
    Note: Text türk. und engl
    Language: English , Turkish
    Keywords: İzer, Zeki Faik 1905-1988
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    Book
    BSZ
  • 4
    Online Resource
    Online Resource
    Immanente Ästhetik, ästhetische Reflexion : Lyrik als Paradigma der Moderne ; Kolloquium Köln 1964 ; Vorlagen und Verhandlungen (1991)
    München : Fink
    Details
    UID:
    (DE-627)1652421572
    Format: 543 S. , Ill., graph. Darst.
    Edition: 3., unveränd. Nachdr. [d. Ausg.] München, 1966 (Online-Ausg.)
    Edition: Online-Ausg. München Bayerische Staatsbibliothek 2010 Online-Ressource Volltext // 2010 digitalisiert von: Bayerische Staatsbibliothek, München. Exemplar der Bayerischen Staatsbibliothek mit der Signatur: 2010.4522
    ISBN: 3770501055
    Series Statement: Poetik und Hermeneutik 2
    Note: Beitr. teilw. dt., teilw. engl , Volltext // 2010 digitalisiert von: Bayerische Staatsbibliothek, München. Exemplar der Bayerischen Staatsbibliothek mit der Signatur: 2010.4522
    Additional Edition: 3770501055
    Additional Edition: Erscheint auch als Druck-Ausgabe Immanente Ästhetik, ästhetische Reflexion München : Fink, 1991 3770501055
    Language: English , German
    Subjects: Comparative Studies. Non-European Languages/Literatures
    RVK:
    EC 4360
    Keywords: Lyrik ; Geschichte 1850-1956 ; Lyriktheorie ; Lyrik ; Poetik ; Geschichte 1850-1960 ; Konferenzschrift
    URN: urn:nbn:de:bvb:12-bsb00046011-5
    URL: kostenfrei
    URL: kostenfrei
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    BSZ
    GBV
  • 5
    Book
    Book
    Bandwidth extension of speech signals (2008)
    Details
    UID:
    (DE-627)1353871339
    Format: III, 152 S. , Ill., graph. Darst.
    Note: Ulm, Univ., Diss., 2008
    Language: English
    Keywords: Hochschulschrift
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    Book
    BSZ
  • 6
    Book
    Book
    The implied reader : patterns of communication in prose fiction from Bunyan to Beckett (1974)
    Baltimore [u.a.] : Johns Hopkins Univ. Press
    Details
    UID:
    (DE-627)211053287
    Format: XIV, 303 S , 23 cm
    ISBN: 080181569X
    Uniform Title: Der implizite Leser 〈engl.〉
    Language: English
    Subjects: English Studies
    RVK:
    HG 650
    Keywords: Englisch ; Roman ; Geschichte 1600-1972
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    BSZ
    GBV
  • 7
    Book
    Book
    Prospecting : from reader response to literary anthropology (1989)
    Baltimore, Md. [u.a.] : Johns Hopkins Univ. Pr.
    Details
    UID:
    (DE-627)275528367
    Format: IX, 316 S.
    ISBN: 0801837928
    Note: Includes indexes
    Language: English
    Subjects: Comparative Studies. Non-European Languages/Literatures
    RVK:
    EC 2110
    Keywords: Englisch ; Literatur ; Geschichte 1590-1985 ; Literaturtheorie ; Literaturtheorie ; Leser ; Literaturwissenschaft ; Literatur ; Anthropologie ; Rezeption ; Literatur ; Literaturgattung ; Rezeptionsästhetik ; Englisch ; Rezeptionsästhetik ; Anthropologie ; Literatur ; Aufsatzsammlung
    URL: http://www.loc.gov/catdir/description/jhu051/88046065.html
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    Book
    Stabi Berlin get availability status
    BSZ
    GBV
  • 8
    Article
    Article
    Amid the wave of youth : the "Innere Mission" and young German migrants in Berlin c. 1900 (2005)
    Show associated volumes
    Details
    UID:
    (DE-627)150797244X
    ISBN: 0754651738
    In: European cities, youth and the public sphere in the twentieth century, Aldershot, Hampshire [u.a.] : Ashgate, 2005, (2005), Seite 8-26, 0754651738
    In: year:2005
    In: pages:8-26
    Language: English
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    Article
    Bildungsgesch. Forschung get availability status
    BSZ
    GBV
  • 9
    Book
    Book
    The act of reading : a theory of aesthetic response (1978)
    London [u.a.] : Routledge & Kegan Paul
    Details
    UID:
    (DE-627)1607787822
    Format: 239 S.
    ISBN: 0710000332
    Uniform Title: Der Akt des Lesens 〈engl.〉
    Language: English
    Subjects: English Studies
    RVK:
    HG 110
    Keywords: USA ; Literatur ; Geschichte ; Lesevorgang ; Englisch ; Literatur ; Geschichte 1700-1960 ; Lesevorgang ; Lesevorgang
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    Book
    BSZ
  • 10
    Book
    Book
    How to do theory (2007)
    Malden, MA [u.a.] : Blackwell Publ.
    Details
    UID:
    (DE-627)641311389
    Format: X, 211 S. , Ill , 23cm
    Edition: 4. [repr.]
    ISBN: 9781405115803 , 9781405115797
    Series Statement: How to study literature
    Language: English
    Subjects: Comparative Studies. Non-European Languages/Literatures , Sociology
    RVK:
    EC 1820
    RVK:
    MR 2000
    Keywords: Literaturtheorie ; Literaturtheorie ; Einführung
    URL: http://www.loc.gov/catdir/enhancements/fy0802/2005004140-b.html
    URL: http://www.loc.gov/catdir/enhancements/fy0802/2005004140-t.html
    URL: http://www.loc.gov/catdir/enhancements/fy0802/2005004140-d.html
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    BSZ
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