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  • BSZ  (54)
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  • 1
    Online Resource
    Online Resource
    Chemical Biology of Neurodegeneration : A Molecular Approach (2019)
    Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
    Details
    UID:
    (DE-627)1676237429
    Format: 1 Online-Ressource (384 S.)
    Edition: 1. Auflage
    ISBN: 3527813438 , 9783527813438
    Content: Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783527344246
    Language: English
    URN: urn:nbn:de:bsz:31-epflicht-1210888
    URL: lizenzpflichtig
    URL: Cover
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    BSZ
  • 2
    Online Resource
    Online Resource
    Chemical Biology of Neurodegeneration : A Molecular Approach (2019)
    Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
    Details
    UID:
    (DE-627)167623733X
    Format: 1 Online-Ressource (384 S.)
    Edition: 1. Auflage
    ISBN: 3527813454 , 9783527813452
    Content: Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783527344246
    Language: English
    URN: urn:nbn:de:bsz:31-epflicht-1210976
    URL: lizenzpflichtig
    URL: Cover
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    BSZ
  • 3
    Online Resource
    Online Resource
    Chemical synthesis of nucleoside analogues (2013)
    Hoboken, N.J : Wiley
    Details
    UID:
    (DE-627)1679593226
    Format: 1 Online-Ressource (xvi, 895 pages) , illustrations
    ISBN: 1118498100 , 1118498178 , 1118498143 , 1118498089 , 1118007514 , 1299242383 , 9781118498149 , 9781118498101 , 9781118498088 , 9781118498170 , 9781118007518 , 9781299242388
    Content: "Compiles current tested and proven approaches to synthesize novel nucleoside analogues. Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides"--Publisher's website
    Content: Deoxynucleoside analogues / Vicente Gotor -- Nucleosides modified at the base moiety / Luigi Agrofoglio -- Acyclic nucleosides / Antonin Holy -- Phosphorylated nucleoside analogues / Giovanni Romeo -- Triphosphorylated nucleoside analogues / Chris Meier -- Pro-nucleotides / Christian Perigaud -- C-nucleoside / Sergio Castillón -- Isonucleosides / Vasu Nair -- Conformationally constrained nucleosides / Jacques Lebreton -- Spironucleosides / Maria Jose Camarasa -- L-nucleosides / Daniela Perrone -- Carbocyclic nucleosides / Eric Leclerc -- Uncommon three-, four, and six-membered nucleosides / Elisabetta Groaz -- Thionucleosides / L.S. Jeong -- Azanucleosides and related compounds / Tomas Tejero -- Oxathiolane and dioxolane nucleosides / Annalisa Guaragna -- Isoxazolidinyl nucleosides / Ugo Chiacchio -- Nucleoside antibiotics / Apurba Dutta -- Building blocks for peptide nucleic acids / Pedro Merino.
    Note: Includes bibliographical references and index , English
    Additional Edition: 9781118007518
    Additional Edition: Erscheint auch als Druck-Ausgabe Chemical synthesis of nucleoside analogues Hoboken, N.J : Wiley, ©2013
    Language: English
    DOI: 10.1002/9781118498088
    URL: lizenzpflichtig
    URL: lizenzpflichtig
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    Online Resource
    Open Access Request
    BSZ
    GBV
  • 4
    Online Resource
    Online Resource
    Chemical Biology of Neurodegeneration : A Molecular Approach (2019)
    Newark : John Wiley & Sons, Incorporated
    Details
    UID:
    (DE-627)1797520075
    Format: 1 Online-Ressource (381 pages)
    ISBN: 9783527813438
    Additional Edition: 9783527344246
    Additional Edition: Erscheint auch als Druck-Ausgabe Merino, Pedro Chemical Biology of Neurodegeneration Newark : John Wiley & Sons, Incorporated,c2019 9783527344246
    Language: English
    URL: lizenzpflichtig
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  • 5
    Online Resource
    Online Resource
    Chemical Synthesis of Nucleoside Analogues. (2013)
    Somerset : Wiley
    Details
    UID:
    (DE-627)1658043014
    Format: 1 online resource (918 pages)
    Edition: 1st ed.
    ISBN: 9781118498170
    Content: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used
    Content: Intro -- CHEMICAL SYNTHESIS OF NUCLEOSIDE ANALOGUES -- CONTENTS -- Contributors -- Foreword -- Preface -- 1 Biocatalytic Methodologies for Selective Modified Nucleosides -- 1. INTRODUCTION -- 2. TRANSFORMATIONS ON THE SUGAR MOIETY -- 2.1. Enzymatic Acylation/Hydrolysis -- 2.2. Resolutions of Racemic Mixtures -- 2.3. Asymmetrizations and Desymmetrizations -- 2.4. Separation of Mixtures -- 2.5. Preparation of Nucleoside Derivatives -- 2.6. Alkoxycarbonylations and Hydrolysis -- 3. BIOTRANSFORMATIONS THAT MODIFY THE BASE -- 4. MOLECULAR MODELING -- 5. CONCLUDING REMARKS -- ABBREVIATIONS -- REFERENCES -- 2 Nucleosides Modified at the Base Moiety -- 1. INTRODUCTION -- 2. RUTHENIUM-CATALYZED C-H BOND ACTIVATION FOR NUCLEOSIDE SYNTHESES -- 3. METALLO-CATALYZED SYNTHESES AND MODIFICATIONS OF TRIAZOLO NUCLEOSIDES -- 3.1. Pd(0)-Catalyzed Functionalization of a 1,2,4-Triazole Ring -- 3.2. Copper/Ruthenium-Catalyzed Azide-Alkyne Cycloadditions to a 1,2,3-Triazole Ring -- 4. SELECTED NUCLEOBASE-MODIFIED NUCLEOSIDES -- 4.1. Ribavirin Analogues -- 4.2. Thio or Seleno Derivatives -- 4.3. Fleximers -- 4.4. Selected Modified Uracil Analogues -- 4.5. Cyclonucleosides -- 4.6. Miscellaneous 5-Substituted Nucleosides -- 5. CONCLUDING REMARKS -- ABBREVIATIONS -- REFERENCES -- 3 Chemical Synthesis of Acyclic Nucleosides -- 1. INTRODUCTION -- 2. SYNTHESIS OF ACYCLIC NUCLEOSIDES -- 2.1. Synthesis of Acyclic Nucleosides with Acyclovir Side-Chain Analogues (Type I) -- 2.2. Synthesis of Acyclic Nucleosides with Ganciclovir Side-Chain Analogues (Type II) -- 2.3. Synthesis of Acyclic Nucleosides with Adefovir Side-Chain Analogues (Type III) -- 2.4. Synthesis of Acyclic Nucleosides with Cidofovir Side-Chain Analogues (Type IV) -- 2.5. Synthesis of Acyclic ucleosides with Buciclovir Side-Chain Analogues (Type V) -- 2.6. New Progress -- 3. OUTLOOK -- ABBREVIATIONS -- REFERENCES.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9781118007518
    Additional Edition: Erscheint auch als Druck-Ausgabe Chemical synthesis of nucleoside analogues Hoboken, N.J : Wiley, 2013 9781118007518
    Language: English
    Subjects: Chemistry/Pharmacy
    RVK:
    VK 8570
    Keywords: Nucleosidanaloga ; Chemische Synthese
    URL: Volltext  (lizenzpflichtig)
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    Online Access
    BSZ
    GBV
  • 6
    Book
    Book
    Chemical synthesis of nucleoside analogues (2013)
    Hoboken, N.J : Wiley
    Details
    UID:
    (DE-627)1602885842
    Format: XVI, 895 S., [2] Bl. , graf. Darst.
    ISBN: 9781118007518
    Note: Includes bibliographical references and index , Deoxynucleoside analogues , Nucleosides modified at the base moiety , Acyclic nucleosides , Phosphorylated nucleoside analogues , Triphosphorylated nucleoside analogues , Pro-nucleotides , C-nucleoside , Isonucleosides , Conformationally constrained nucleosides , Spironucleosides , L-nucleosides , Carbocyclic nucleosides , Uncommon three-, four, and six-membered nucleosides , Thionucleosides , Azanucleosides and related compounds , Oxathiolane and dioxolane nucleosides , Isoxazolidinyl nucleosides , Nucleoside antibiotics , Building blocks for peptide nucleic acids
    Additional Edition: 9781118498170
    Additional Edition: Erscheint auch als Online-Ausgabe Merino, Pedro Chemical Synthesis of Nucleoside Analogues. Somerset : Wiley, 2013 9781118498170
    Language: English
    Subjects: Chemistry/Pharmacy
    RVK:
    VK 8570
    Keywords: Nucleosidanaloga ; Chemische Synthese ; Nucleosidanaloga ; Chemische Synthese
    URL: Cover
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    Book
    BSZ
  • 7
    Online Resource
    Online Resource
    Chemical Biology of Neurodegeneration : A Molecular Approach (2019)
    Newark : John Wiley & Sons, Incorporated
    Details
    UID:
    (DE-627)1679836501
    Format: 1 online resource (381 pages)
    ISBN: 9783527813438
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783527344246
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783527344246
    Language: English
    URL: lizenzpflichtig
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    BSZ
    GBV
  • 8
    Article
    Article
    La interioridad como encuentro : Reflexión sobre la interiorización trascendida agustiniana (2016)
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    Details
    UID:
    (DE-627)1638045003
    ISSN: 1122-5661
    In: Recollectio, Roma : Inst., 1978, 39(2016), Seite 233-254, 1122-5661
    In: volume:39
    In: year:2016
    In: pages:233-254
    Language: Spanish
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    Article
    BSZ
  • 9
    Article
    Article
    Las hermandades rocieras de Sevilla y su camino anual al Rocío (2001)
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    Details
    UID:
    (DE-627)1535291435
    ISBN: 8440491921
    In: Peregrinación y santuarios en los archivos de la Iglesia, Oviedo : Asociación de Archiveros de la Iglesia en España, 2001, (2001), Seite 429-445, 8440491921
    In: year:2001
    In: pages:429-445
    Language: Spanish
    Keywords: El Rocío ; Marienwallfahrt ; Bruderschaft ; Sevilla
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    Article
    BSZ
  • 10
    Article
    Article
    El liderazgo como acicate de comunidades vivas en el ámbito de la revitalización (2015)
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    Details
    UID:
    (DE-627)1638044228
    ISSN: 1122-5661
    In: Recollectio, Roma : Inst., 1978, 38(2015), Seite 151-176, 1122-5661
    In: volume:38
    In: year:2015
    In: pages:151-176
    Language: Spanish
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