In:
Applied Organometallic Chemistry, Wiley, Vol. 18, No. 10 ( 2004-10), p. 514-519
Abstract:
Carboxymethyl dextran (CMD) with varying degrees of substitution was prepared and used as biocompatible coating for magnetic iron oxide nanoparticles. An oligonucleotide (19‐mer) was coupled to the CMD‐coated particles as a model compound for DNA fragments. Transmission electron microscopy investigations on the cellular uptake of the particles by different tumor cell lines demonstrated that both the CMD‐coated and the oligonucleotide‐coupled particles are internalized by the cells and deposited in cellular endosomes. The nanoparticles prepared have potential applications in tumor diagnosis and therapy. Copyright © 2004 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0268-2605
,
1099-0739
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
1480791-9
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