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  • GBV  (115)
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  • 1
    Book
    Book
    Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1 (2008)
    Details
    UID:
    (DE-627)632058617
    Format: 175 Bl. , Ill., graph. Darst , 1 DVD
    Note: Göttingen, Univ., Diss., 2008
    Additional Edition: Online-Ausg. Agarwal, Amit Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1 2008
    Language: English
    Keywords: Hochschulschrift
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    GBV
  • 2
    Online Resource
    Online Resource
    Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1 : = Kortexentwicklung und Myelinisierung in Nullmutanten des Schizophrenie-Risikogens NRG1 (2008)
    Details
    UID:
    (DE-627)632059869
    Format: Online-Ressource (PDF-Datei: 180 S., 20.000 KB; AVI: 817.332 KB) , Ill., graph. Darst , 1 DVD
    Edition: 2009 [Online-Ausg.]
    Edition: Online-Ausg.:
    Content: Neuregulin1 (NRG1), a gene on human chromosome 8p, encodes a family of widely expressed EGF-like growth factors that signal via ErbB receptors tyrosine kinases. The best understood function of murine NRG1 is the control of myelination in the peripheral nervous system (PNS). The identification of human NRG1 as a susceptibility gene for schizophrenia has renewed interest in the contribution of NRG1/ErbB signaling in brain development. Based on in vitro studies, multiple functions of NRG1 have been suggested for the CNS, including oligodendrocyte differentiation and myelination, neuronal migration and synaptic plasticity. However, functional in vivo data are lacking as NRG1 mutant mice die embryonically. As a first step to understand NRG1 function in vivo we generated a series of conditional mouse mutants that completely lack NRG1 expression beginning at different stages of neural development ...
    Note: Göttingen, Univ., Diss., 2008 , Online-Ausg.: , [Online-Ausg.]
    Additional Edition: Druckausg. Agarwal, Amit Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1 2008
    Language: English
    Keywords: Hochschulschrift
    URN: urn:nbn:de:gbv:7-webdoc-2202-6
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Volltext
    URL: Volltext  (kostenfrei)
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  • 3
    Online Resource
    Online Resource
    Simulation Studies of Recombination Kinetics and Spin Dynamics in Radiation Chemistry (2014)
    Cham : Springer International Publishing AG
    Details
    UID:
    (DE-627)1746195649
    Format: 1 online resource (354 pages)
    Edition: 1st ed.
    ISBN: 9783319062723
    Series Statement: Springer Theses Ser.
    Content: Amit Agarwal's thesis reports a substantial contribution to the microscopic simulation of radiation chemical reactions. In his research Agarwal extends existing models to further understand scavenging, spin and relaxation effects.?This research has advanced the development of both the Monte Carlo Random Flights and the Independent Reaction Times (IRT) simulation tools.?Particular highlights are the extension of these tools to include both the spin-exchange interaction and spin relaxation, both of which are influential in radiolytic systems where many reactions are spin-controlled.?In addition, the study has led to the discovery of a novel correlation of the scavenging rate with the recombination time in low permittivity solvents. This finding goes against existing assumptions underlying the theory of diffusion kinetics while still being accommodated in the IRT method which demonstrates the power of this unconventional approach. The work in this thesis can be applied to a wide number of fields including the nuclear industry, medicine,?food treatment, polymer curing, the preparation of nano-colloids, power generation and waste disposal.
    Content: Intro -- Supervisor's Foreword -- Preface -- Acknowledgments -- Contents -- Symbols and Abbreviations -- 1 Introduction to Radiation Chemistry -- 1.1 Aims and Motivation -- 1.2 Ionising Radiation and Energy Loss -- 1.2.1 Charged Particles -- 1.2.2 Electromagnetic Radiation -- 1.2.3 Neutrons -- 1.3 Radiolysis of Water -- 1.3.1 Physico-Chemical Stage -- 1.3.2 Chemical Stage in Water -- 1.4 Radiolysis of Hydrocarbons -- 1.4.1 Electron Mobility -- 1.4.2 Hole Mobility -- 1.4.3 Scintillator Species -- 1.4.4 Non-random Bond Rupture -- 1.5 Macroscopic Theory of Spur Kinetics -- 1.5.1 Problems with the Deterministic Theory -- References -- 2 Theory of Scavenging and Recombination Kinetics -- 2.1 Introduction -- 2.2 Homogeneous Kinetics -- 2.2.1 Neutral Species in Solution -- 2.2.2 Ions in Solution -- 2.3 Diffusion as a Stochastic Process -- 2.3.1 Introduction -- 2.3.2 One Dimensional Diffusion Process -- 2.3.3 Three Dimensional Diffusion -- 2.3.4 Other Models of Molecular Motion -- 2.4 Geminate Recombination -- 2.4.1 Diffusion Controlled Reactions -- 2.4.2 Partially Diffusion Controlled Reactions -- 2.5 Bulk Recombination Rate Constant -- 2.5.1 Independent Pairs Approximation -- 2.6 Scavenging Kinetics -- 2.6.1 Scavenger Concentration and the Inverse Laplace Transform Relationship -- 2.6.2 Competition Between Scavenging and Recombination -- 2.7 Spin-Controlled Reactions -- 2.7.1 Recovering Boundary Model -- References -- 3 Spin Dynamics -- 3.1 Introduction -- 3.2 Stochastic Liouville Theory -- 3.3 Coherent Spin Evolution -- 3.3.1 Zeeman Interaction -- 3.3.2 Hyperfine Interaction -- 3.3.3 Exchange Interaction -- 3.4 Incoherent Spin Evolution -- 3.4.1 Bloch Equations -- 3.4.2 Solomon Equations -- 3.4.3 Redfield Theory -- 3.4.4 Measuring Spin Relaxation -- 3.4.5 Spin-Locking -- 3.5 Radical Pair Mechanism -- 3.5.1 Introduction.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783319062716
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783319062716
    Language: English
    URL: lizenzpflichtig
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  • 4
    Online Resource
    Online Resource
    Simulation Studies of Recombination Kinetics and Spin Dynamics in Radiation Chemistry (2014)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-627)1656307855
    Format: Online-Ressource (XXV, 339 p. 135 illus., 107 illus. in color, online resource)
    ISBN: 9783319062723
    Series Statement: Springer Theses, Recognizing Outstanding Ph.D. Research
    Content: Amit Agarwals thesis reports a substantial contribution to the microscopic simulation of radiation chemical reactions. In his research Agarwal extends existing models to further understand scavenging, spin and relaxation effects. This research has advanced the development of both the Monte Carlo Random Flights and the Independent Reaction Times (IRT) simulation tools. Particular highlights are the extension of these tools to include both the spin-exchange interaction and spin relaxation, both of which are influential in radiolytic systems where many reactions are spin-controlled. In addition, the study has led to the discovery of a novel correlation of the scavenging rate with the recombination time in low permittivity solvents. This finding goes against existing assumptions underlying the theory of diffusion kinetics while still being accommodated in the IRT method which demonstrates the power of this unconventional approach. The work in this thesis can be applied to a wide number of fields including the nuclear industry, medicine, food treatment, polymer curing, the preparation of nano-colloids, power generation and waste disposal.
    Note: Description based upon print version of record , Supervisor's Foreword; Preface; Acknowledgments; Contents; Symbols and Abbreviations; 1 Introduction to Radiation Chemistry; 1.1 Aims and Motivation; 1.2 Ionising Radiation and Energy Loss; 1.2.1 Charged Particles; 1.2.2 Electromagnetic Radiation; 1.2.3 Neutrons; 1.3 Radiolysis of Water; 1.3.1 Physico-Chemical Stage; 1.3.2 Chemical Stage in Water; 1.4 Radiolysis of Hydrocarbons; 1.4.1 Electron Mobility; 1.4.2 Hole Mobility; 1.4.3 Scintillator Species; 1.4.4 Non-random Bond Rupture; 1.5 Macroscopic Theory of Spur Kinetics; 1.5.1 Problems with the Deterministic Theory; References , 2 Theory of Scavenging and Recombination Kinetics2.1 Introduction; 2.2 Homogeneous Kinetics; 2.2.1 Neutral Species in Solution; 2.2.2 Ions in Solution; 2.3 Diffusion as a Stochastic Process; 2.3.1 Introduction; 2.3.2 One Dimensional Diffusion Process; 2.3.3 Three Dimensional Diffusion; 2.3.4 Other Models of Molecular Motion; 2.4 Geminate Recombination; 2.4.1 Diffusion Controlled Reactions; 2.4.2 Partially Diffusion Controlled Reactions; 2.5 Bulk Recombination Rate Constant; 2.5.1 Independent Pairs Approximation; 2.6 Scavenging Kinetics , 2.6.1 Scavenger Concentration and the Inverse Laplace Transform Relationship2.6.2 Competition Between Scavenging and Recombination; 2.7 Spin-Controlled Reactions; 2.7.1 Recovering Boundary Model; References; 3 Spin Dynamics; 3.1 Introduction; 3.2 Stochastic Liouville Theory; 3.3 Coherent Spin Evolution; 3.3.1 Zeeman Interaction; 3.3.2 Hyperfine Interaction; 3.3.3 Exchange Interaction; 3.4 Incoherent Spin Evolution; 3.4.1 Bloch Equations; 3.4.2 Solomon Equations; 3.4.3 Redfield Theory; 3.4.4 Measuring Spin Relaxation; 3.4.5 Spin-Locking; 3.5 Radical Pair Mechanism; 3.5.1 Introduction , 3.5.2 Radical-Triplet Pair Mechanism3.5.3 Zero Field Splitting; 3.5.4 Chemically Induced Dynamic Nuclear Polarisation; 3.5.5 Chemically Induced Dynamic Electron Polarisation; 3.5.6 S-T0 Mixing; 3.5.7 S-T-1 Mixing; 3.6 Triplet Mechanism; 3.7 Magnetic Field Effect; 3.7.1 Low Field Effect; 3.7.2 Quantum Beats; 3.7.3 Magnetic Effect on Reaction Yield; 3.7.4 Optically Detected Magnetic Resonance; 3.7.5 Reaction Yield Detected Magnetic Resonance; 3.8 Summary; References; 4 Simulation Techniques and Development; 4.1 Introduction; 4.2 Random Number Generation , 4.3 Monte Carlo Random Flights Simulation4.3.1 Introduction; 4.3.2 Brownian Bridge Probability; 4.3.3 Reflection; 4.3.4 New Variable Time Step Algorithm; 4.3.5 Partially Diffusion Controlled Reactions; 4.3.6 Exact Simulation of Sample Paths; 4.4 Independent Reaction Times; 4.4.1 Introduction; 4.4.2 Diffusion Controlled Reactions: Neutral Species; 4.4.3 Partially Diffusion Controlled Reactions: Neutral Species; 4.4.4 Ionic Species; 4.5 Hybrid Simulation Package; 4.5.1 Choice of the Critical Boundary; 4.6 Slice Simulation Package , 4.6.1 Situation 1: Mean Exit Time Between Slices for Neutral Species
    Additional Edition: 9783319062716
    Additional Edition: Druckausg. 978-331-90627-1-6
    Language: English
    DOI: 10.1007/978-3-319-06272-3
    URL: Volltext
    URL: Volltext
    URL: Cover
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  • 5
    Article
    Article
    Optimizing Job Scheduling in Federated Grid System (2017)
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    Details
    UID:
    (DE-627)1877543713
    ISBN: 9789811038174
    In: ICICSE (4. : 2016 : Hyderabad, Telangana), Innovations in computer science and engineering, Singapore : Springer, 2017, (2017), Seite 97-104, 9789811038174
    In: year:2017
    In: pages:97-104
    Language: English
    DOI: 10.1007/978-981-10-3818-1_11
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  • 6
    Online Resource
    Online Resource
    Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility (29)
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    Details
    UID:
    (DE-627)1690894601
    Format: 33
    ISSN: 2050-084X
    Content: The inwardly rectifying K+ channel Kir4.1 is broadly expressed by CNS glia and deficits in Kir4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte Kir4.1 channels in controlling myelination and K+ clearance in white matter has not been defined. Here, we show that selective deletion of Kir4.1 from oligodendrocyte progenitors (OPCs) or mature oligodendrocytes did not impair their development or disrupt the structure of myelin. However, mice lacking oligodendrocyte Kir4.1 channels exhibited profound functional impairments, including slower clearance of extracellular K+ and delayed recovery of axons from repetitive stimulation in white matter, as well as spontaneous seizures, a lower seizure threshold, and activity-dependent motor deficits. These results indicate that Kir4.1 channels in oligodendrocytes play an important role in extracellular K+ homeostasis in white matter, and that selective loss of this channel from oligodendrocytes is sufficient to impair K+ clearance and promote seizures.
    Note: Gesehen am 25.02.2020
    In: eLife, Cambridge : eLife Sciences Publications, 2012, 7(2018) Artikel-Nummer e34829, 33 Seiten, 2050-084X
    In: volume:7
    In: year:2018
    In: extent:33
    Language: English
    DOI: 10.7554/eLife.34829
    URL: Volltext
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  • 7
    Online Resource
    Online Resource
    Evidence-based endocrine surgery (2018)
    Singapore : Springer
    Details
    UID:
    (DE-627)1031836349
    Format: 1 Online-Ressource (IX, 484 Seiten) , Illustrationen
    Edition: Springer eBook Collection. Medicine
    ISBN: 9789811011245
    Series Statement: SpringerLink
    Content: In this textbook, leading experts from highly acclaimed institutions describe evidence-based best practice in the management of a wide range of benign and malignant thyroid, parathyroid, adrenal, and neuroendocrine conditions. Detailed attention is devoted to the current role of surgery, including minimally invasive surgery and robotic surgery, in different endocrine disorders. The reader will also learn how best to respond to the problems that may be encountered during endocrine surgical practice. While much of the focus is on surgical aspects, the approach is multidisciplinary, with inclusion of information on recent advances in epidemiology, genetics, cytology, pathology, imaging modalities, and other treatment options. The clear text is complemented by instructive clinical cases as well as numerous high-quality illustrations and tables summarizing key points. This book will be of value for specialists in endocrine medicine and surgery as well as general surgeons with an interest in endocrine surgery
    Content: THYROIDOLOGY -- Benign thyroid disease: Overview -- Chapter. Anatomy and Physiology of the thyroid -- Chapter. Genetics of thyroid disease -- Chapter. Investigating a thyroid nodule -- Chapter. Nodular goiter -- Chapter. Investigating hyperthyroidism -- Chapter. Thyroiditis -- Chapter. Subclinical thyroid disease -- Chapter. Grave’s disease -- Chapter. Cytology of benign disease -- Thyroid oncology: Overview -- Chapter. Molecular pathogenesis of thyroid cancer -- Chapter. Cytology of malignant disease -- Chapter. Differentiated thyroid cancer -- Chapter. Medullary thyroid cancer -- Chapter. Anaplastic thyroid cancer -- Chapter. Imaging in thyroid cancer -- Chapter. Locally Advanced Thyroid cancer -- Chapter. Neck dissection in thyroid cancer -- Chapter. RAI ablation in cancer -- Chapter. Management of metastatic thyroid cancer -- Thyroid technology& outcomes: Overview -- Chapter: Neuromonitoring in thyroid surgery -- Chapter: Robotic and Endoscopic thyroid surgery -- Chapter: Outcomes in thyroid surgery -- PARATHYROID -- Benign disease overview -- Chapter: Anatomy and Physiology of the parathyroidgland -- Chapter: Investigating primary hyperparathyroidism -- Chapter: Asymptomatic and normocalcaemic HPT -- Chapter: Managing primary HPT and related complications -- Chapter: Parathyroid surgery -- Chapter: Adjuncts in parathyroid surgery -- Chapter: Renal hyperparathyroidism -- Chapter: Outcomes of parathyroid surgery -- Chapter: Reoperative parathyroid surgery -- Malignant disease and miscellaneous -- Chapter: Genetics of parathyroid disease -- Chapter: Parathyroid cancer -- Chapter: Ethanol ablation for parathyroid disease -- ADRENAL -- Overview -- Chapter: Anatomy and Physiology of the adrenal gland -- Chapter: Genetics of adrenal tumours -- Chapter: Incidentaloma -- Chapter: Cushing’s syndrome -- Chapter: Conn’s syndrome -- Chapter: Adrenocortical cancer -- Chapter: Paraganglionomas -- Chapter: Perioperative management of endocrine hypertension -- Chapter: Laparoscopic adrenalectomy -- Chapter: Complications of adrenal surgery -- NEUROENDOCRINE -- Overview -- Chapter: Epidemiology of NET’s -- Chapter: Pathology of NET’s -- Chapter: Imaging in NET’s -- Chapter: Gastric NET’s -- Chapter: Pancreatic NET’s -- Chapter: Carcinoid tumours -- Chapter: Chemotherapy and adjuvant treatment -- Chapter: Outcomes in NET’s
    Additional Edition: 9789811011238
    Additional Edition: 9789811011252
    Additional Edition: Erscheint auch als Druck-Ausgabe 978-981-10-1123-8
    Language: English
    DOI: 10.1007/978-981-10-1124-5
    URL: Volltext  (lizenzpflichtig)
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  • 8
    Online Resource
    Online Resource
    Systemic Risk and Heavy Tails : The Case of Banks’ Loan Portfolio (2011)
    [S.l.] : SSRN
    Details
    UID:
    (DE-627)1793020272
    Format: 1 Online-Ressource (26 p)
    Content: We estimate a Pareto distribution for loan losses, as an alternative to the commonly used Vasicek distribution, using simulated data. A key assumption in the construction of Vasicek distribution is that firm-level risk is idiosyncratic. It also assumes that firm exposure to systemic risk is constant across firms (captured by R1/2). But profitability may decline differently across firms in a recession in ways that are both systematic and related to firm characteristics, such as size, sector, or firm-level fixed effects. Finally, when calculating expected loss under the Vasicek framework, the probability of default (PD) and loss given default (LGD) of loans are assumed to be uncorrelated. Yet, evidence points to correlations between PD and LGD especially when systemic risk is dominant. (c.f. Miu and Ozdemir, 2006, Altman, Reti and Sironi, 2005). Its possibility has also been discussed in the BASEL final rule (Federal Register 2007 p. 69309).We use a Pareto distribution to overcome these restrictions. We find a higher probability of large losses than has been understood thus far. We examine our findings, based on simulated data that reproduce a bank's mean PD and LGD values. The findings do show that the Pareto distribution predicts a higher likelihood of tail events and fits the data more closely, when compared with the Vasicek distribution. The threshold or cross-over point at which this "tail" result obtains corresponds to PDs ranging from 1% to 2%, a range found in the mid to mid-high risk segments for many banks' portfolios. The use of Pareto distribution is consistent with the new thinking about the role of Power Law in explaining tail events (Gabaix, et. al, 2006, 2008)
    Note: Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments March 2011 erstellt
    Language: English
    DOI: 10.2139/ssrn.1787258
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  • 9
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    Assessing social support and stress in autism-focused virtual communities : emerging research and opportunities (2018)
    Hershey, PA : IGI Global
    Details
    UID:
    (DE-627)1022249223
    Format: 1 Online-Ressource
    ISBN: 9781522540212
    Content: "This book explores social support and stress in Autism-focused virtual communities. It covers topics such as autism and social media, social support and stress, social support assessment, and stress assessment"...
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 10
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    Assessing social support and stress in autism-focused virtual communities : emerging research and opportunities (2017)
    Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, Pennsylvania, 17033, USA) : IGI Global
    Details
    UID:
    (DE-627)1654461636
    Format: 1 Online-Ressource(18 PDFs (x, 131 pages))
    ISBN: 9781522540212
    Content: "This book explores social support and stress in Autism-focused virtual communities. It covers topics such as autism and social media, social support and stress, social support assessment, and stress assessment"--
    Additional Edition: 9781522540205
    Additional Edition: Druck-Ausgabe 9781522540205
    Language: English
    DOI: 10.4018/978-1-5225-4020-5
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