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  • 1
    Online Resource
    Online Resource
    Interest in Integrative Medicine Among Postmenopausal Hormone Receptor–Positive Breast Cancer Patients in the EvAluate-TM Study
    SAGE Publications ; 2017
    In:  Integrative Cancer Therapies Vol. 16, No. 2 ( 2017-06), p. 165-175
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 16, No. 2 ( 2017-06), p. 165-175
    Abstract: Background. Breast cancer patients often use complementary and alternative medicine, but few prospectively collected data on the topic are available specifically for postmenopausal breast cancer patients. A large prospective study was therefore conducted within a noninterventional study in order to identify the characteristics of patients interested in integrative medicine. Methods. The EvAluate-TM study is a prospective, multicenter noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor–positive primary breast cancer. Between 2008 and 2009, 5045 postmenopausal patients were enrolled at 339 certified breast centers in Germany. As part of the data collection process, patients were asked at the baseline about their interest in and information needs relating to integrative medicine. Results. Of the 5045 patients recruited, 3411 responded to the questionnaire on integrative medicine and took part in the analysis, 1583 patients expressed an interest in integrative medicine, and 1828 patients declared no interest. Relevant predictors of interest in integrative medicine were age, body mass index, tumor size, previous chemotherapy, and use of concomitant medications for other medical conditions. Interest in integrative medicine declined highly significantly ( P 〈 .001) with age ( 〈 50 years, 74.1%; 50-60 years, 54.1%; 〉 65 years, 38.0%). Patients in favor of integrative medicine were significantly less satisfied with the information received about individual treatments and antihormonal therapy. Patients with interest in integrative medicine were more often interested in rehabilitation and fitness, nutritional counseling, and additional support from self-help organizations. These women were mostly interested in receiving information about their disease and integrative medicine from a physician, rather than from other sources. Conclusions. This study shows that a considerable proportion of postmenopausal breast cancer patients are interested in integrative medicine. Information about integrative medicine should therefore be provided as part of patient care for this group. It was found that receiving concomitant medication for other medical conditions is one of the main predictors for women not being interested in integrative medicine. This group of patients may need special attention and individualized information about integrative medicine. Additionally, most patients were interested in obtaining the relevant information from their doctor.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735416668575
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2101248-9
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
  • 2
    Online Resource
    Online Resource
    The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study
    SAGE Publications ; 2008
    In:  Alternatives to Laboratory Animals Vol. 36, No. 2 ( 2008-05), p. 161-187
    Details
    In: Alternatives to Laboratory Animals, SAGE Publications, Vol. 36, No. 2 ( 2008-05), p. 161-187
    Abstract: A formal validation study was performed, in order to investigate whether the commercially-available reconstructed human epidermis (RHE) models, EPISKIN®, EpiDerm™ and SkinEthic®, are suitable for in vitro skin absorption testing. The skin types currently recommended in the OECD Test Guideline 428, namely, ex vivo human epidermis and pig skin, were used as references. Based on the promising outcome of the prevalidation study, the panel of test substances was enlarged to nine substances, covering a wider spectrum of physicochemical properties. The substances were tested under both infinite-dose and finite-dose conditions, in ten laboratories, under strictly controlled conditions. The data were subjected to independent statistical analyses. Intra-laboratory and inter-laboratory variability contributed almost equally to the total variability, which was in the same range as that in preceding studies. In general, permeation of the RHE models exceeded that of human epidermis and pig skin (the SkinEthic RHE was found to be the most permeable), yet the ranking of substance permeation through the three tested RHE models and the pig skin reflected the permeation through human epidermis. In addition, both infinite-dose and finite-dose experiments are feasible with RHE models. The RHE models did not show the expected significantly better reproducibility, as compared to excised skin, despite a tendency toward lower variability of the data. Importantly, however, the permeation data showed a sufficient correlation between all the preparations examined. Thus, the RHE models, EPISKIN, EpiDerm and SkinEthic, are appropriate alternatives to human and pig skin, for the in vitro assessment of the permeation and penetration of substances when applied as aqueous solutions.
    Type of Medium: Online Resource
    ISSN: 0261-1929 , 2632-3559
    URL: Article
    DOI: 10.1177/026119290803600207
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2390905-5
    SSG: 12,22
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  • 3
    Online Resource
    Online Resource
    Letter to the editor
    SAGE Publications ; 2004
    In:  Multiple Sclerosis Journal Vol. 10, No. 2 ( 2004-04), p. 243-244
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 10, No. 2 ( 2004-04), p. 243-244
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1191/1352458504ms999xx
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2008225-3
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
  • 4
    Online Resource
    Online Resource
    Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study
    SAGE Publications ; 2006
    In:  Alternatives to Laboratory Animals Vol. 34, No. 3 ( 2006-06), p. 283-294
    Details
    In: Alternatives to Laboratory Animals, SAGE Publications, Vol. 34, No. 3 ( 2006-06), p. 283-294
    Abstract: Exposure to chemicals absorbed by the skin can threaten human health. In order to standardise the predictive testing of percutaneous absorption for regulatory purposes, the OECD adopted guideline 428, which describes methods for assessing absorption by using human and animal skin. In this study, a protocol based on the OECD principles was developed and prevalidated by using reconstructed human epidermis (RHE). The permeation of the OECD standard compounds, caffeine and testosterone, through commercially available RHE models was compared to that of human epidermis and animal skin. In comparison to human epidermis, the permeation of the chemicals was overestimated when using RHE. The following ranking of the permeation coefficients for testosterone was obtained: SkinEthic 〉 EpiDerm, EPISKIN 〉 human epidermis, bovine udder skin, pig skin. The ranking for caffeine was: SkinEthic, EPISKIN 〉 bovine udder skin, EpiDerm, pig skin, human epidermis. The inter-laboratory and intra-laboratory reproducibility was good. Long and variable lag times, which are a matter of concern when using human and pig skin, did not occur with RHE. Due to the successful transfer of the protocol, it is now in the validation process.
    Type of Medium: Online Resource
    ISSN: 0261-1929 , 2632-3559
    URL: Article
    DOI: 10.1177/026119290603400312
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2390905-5
    SSG: 12,22
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  • 5
    Online Resource
    Online Resource
    Does Intervention Improve the Natural Course of Glomus Tumors? : A Series of 108 Patients Seen in a 32-Year Period
    SAGE Publications ; 1992
    In:  Annals of Otology, Rhinology & Laryngology Vol. 101, No. 8 ( 1992-08), p. 635-642
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 101, No. 8 ( 1992-08), p. 635-642
    Abstract: To acquire more insight into the results of treatment versus the “natural” course of glomus tumors, we studied the clinical data of 108 patients, in 58 of whom the disease was hereditary. During a period of 32 years (1956 to 1988), 175 tumors were diagnosed: 52 glomus jugulotympanic tumors, 32 vagal body tumors, and 91 carotid body tumors. The results of radical surgical treatment were disappointing for tumors located at the skull base, ie, nonradical in 59% (n = 23) of the cases, but very good for the carotid body tumors, for which 96% (n = 68) radical excision was achieved. Moreover, surgery at the level of the skull base dramatically increased morbidity, since it frequently induced cranial nerve palsy. During the follow-up period (maximal observation time 32 years, mean 13.5 years) none of the patients died of residual or recurrent tumor or developed distant metastases, irrespective of the mode and outcome of treatment. When these results are combined with the results of pedigree analysis, a realistic approximation of the “natural” course of the disease for both hereditary and nonfamilial tumors can be made. The results raise the question of whether this natural behavior is really improved by intervention. We conclude that removal of carotid body tumors and solitary vagal body tumors should be considered in order to prevent future morbidity. However, for skull base and bilateral glomus tumors a more conservative monitored “wait and see” policy can be sensible and should be considered in any proposal for treatment of head and neck paragangliomas. When there is serious progression of cranial nerve palsy or when intracranial growth becomes life-threatening, surgical intervention cannot be avoided. The main goal of glomus tumor treatment should be to reduce morbidity rather than trying to increase survival rates.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348949210100802
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1992
    detail.hit.zdb_id: 2033055-8
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  • 6
    Online Resource
    Online Resource
    Organisations and regional innovative capability: the case of the chambers of commerce and industry in Germany
    SAGE Publications ; 2015
    In:  Environment and Planning C: Government and Policy Vol. 33, No. 4 ( 2015-08), p. 811-827
    Details
    In: Environment and Planning C: Government and Policy, SAGE Publications, Vol. 33, No. 4 ( 2015-08), p. 811-827
    Abstract: Spatial innovation models focus on the region and highlight the social and economic interactions of the actors as a main factor in regional innovative output. This paper examines the role of German chambers of commerce and industry (CCIs), which could be relevant for the innovation process through: (1) moderating or founding regional and local (innovative) initiatives; (2) creating and maintaining formal and informal networks; (3) building reputations and providing references; (4) providing information and advisory services; (5) conducting final examinations in vocational training; and (6) founding educational institutions. The empirical analyses show a positive impact of CCI expenditures on the number of start-ups and the number of patents, as well as a positive impact of seminar and information day participation on the number of start-ups. The results lead to the assumption that the network effect (functions 2 and 3) plays a more important role than providing pure information and advice (function 4).
    Type of Medium: Online Resource
    ISSN: 0263-774X , 1472-3425
    URL: Article
    DOI: 10.1068/c12201b
    RVK:
    MA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 878440-1
    detail.hit.zdb_id: 2039725-2
    SSG: 3,4
    SSG: 3,6
    SSG: 3,7
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  • 7
    Online Resource
    Online Resource
    Quantitative Correlation at the Molecular Level of Tumor Response to Docetaxel by Multimodal Diffusion-Weighted Magnetic Resonance Imaging and [ 18 F]FDG/[ 18 F]FLT Positron Emission Tomography
    SAGE Publications ; 2015
    In:  Molecular Imaging Vol. 14, No. 1 ( 2015-01), p. 7290.2014.00045-
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 14, No. 1 ( 2015-01), p. 7290.2014.00045-
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    URL: Article
    DOI: 10.2310/7290.2014.00045
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2069848-3
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
  • 8
    Online Resource
    Online Resource
    Acoustical Analysis of Posed Prosodic Expressions: Effects of Emotion and Sex
    SAGE Publications ; 2003
    In:  Perceptual and Motor Skills Vol. 96, No. 3 ( 2003-06), p. 759-771
    Details
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 96, No. 3 ( 2003-06), p. 759-771
    Abstract: Prosodic expression is an important channel of emotional communication and can be assessed through computerized acoustical analysis. Fundamental Frequency (F 0 ) is the most commonly studied acoustic measure and considered the best index of perceived pitch. In this study, we examined two factors that can influence prosodic expression, sex and emotion type, A special feature is the use of a neutral expression as a control measure. We also described procedures for eliciting posed prosodic expression via an experimental task from the New York Emotion Battery. Subjects were healthy men ( n=10) and women ( n=9), matched for. age ( M = 29.2 yr.) and education ( M= 15.6 yr). Subjects were asked to intone neutral-content sentences with happy, sad, and neutral prosody. F 0 mean and standard deviation were measured using the Computerized Speech Lab program. Initial findings indicated that women produced significantly higher F 0 values than did men and that happy sentences were produced with significantly higher F 0 values than were sad sentences. When semitone conversions were applied and neutral prosody was subtracted out, differences remained for emotion type but not for sex. Findings are discussed in terms of implications for the assessment and treatment of prosody in clinical populations.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    URL: Article
    DOI: 10.2466/pms.2003.96.3.759
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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  • 9
    Online Resource
    Online Resource
    Quantitative Measurements of Cerebral Blood Flow Using SPECT and [ 99m Tc]- d,l -HM-PAO Compared to Xenon-133
    SAGE Publications ; 1988
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 8, No. 1_suppl ( 1988-12), p. S69-S81
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 8, No. 1_suppl ( 1988-12), p. S69-S81
    Abstract: The uptake and retention in a 2 cm thick brain section was recorded serially by SPECT after i.v. injection of [ 99m Tc]– d,l-HM-PAO (HM-PAO). In 16 patients, the fraction of the administered dose retained by the brain was 5.2 ± 1%, showing a peak after 40–50s, then decreasing by 10% within the first 10 min and then by only 0.4% per hour. The image contrast was measured in each patient as the regional hemispheric asymmetry difference in percent of the highest value of the two regions. It deceased from 31% at 30–40 s to 25% at 10 min. At 24 h, a value of 19% was reached. Using the images obtained at 10 min after injection, a region to region comparison of the original and corrected HM-PAO images to the xenon-133 regional cerebral blood flow (rCBF) images was performed. Forty-four patients with stroke, epilepsy, dementia, basal ganglia disease, and tumors and control subjects were included in this comparison. The algorithm proposed by Lassen et al. was used to correct the original images for back diffusion of tracer (brain to blood); a good correlation very close to the line of identity between the corrected HM-PAO and xenon-133 data was obtained when using a conversion/clearance ratio of 1.5 and when the noninvolved hemisphere was used as a reference region ( r = 0.86, p 〈 0.0001). Serial arterial and cerebral venous blood sampling was performed over 10 min following i.v. injection of HM-PAO in six patients. An overall brain retention fraction of 0.37 ± 0.03 (mean ± SEM) was calculated from the data. An average CBF of 0.62 ± 0.12 ml/g/min was determined on the basis of the Fick principle; this compared to a value of 0.59 ± 0.09 ml/g/min (mean ± SEM) measured by the xenon-133 inhalation method. The two sets of CBF values correlated linearly with a correlation coefficient of 0.97 ( p 〈 0.01). Inserting the average CBF value for the hemisphere as measured by the Fick principle into the algorithm described by Lassen et al. yields absolute rCBF values (ml/g/min) directly from the corrected HM-PAO images. We conclude that the xenon-133 inhalation method and [ 99m Tc]– d,l-HM-PAO may supplement each other for SPECT studies of rCBF: xenon-133 inhalation for easy, repeatable, and quantitative measurements and [ 99m Tc]– d,l-HM-PAO for high resolution static imaging in relative or absolute flow units.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.1988.35
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1988
    detail.hit.zdb_id: 2039456-1
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  • 10
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    Online Resource
    Student Newspapers Show Opinion Article Political Bias
    SAGE Publications ; 2015
    In:  Newspaper Research Journal Vol. 36, No. 1 ( 2015-01), p. 6-23
    Details
    In: Newspaper Research Journal, SAGE Publications, Vol. 36, No. 1 ( 2015-01), p. 6-23
    Type of Medium: Online Resource
    ISSN: 0739-5329 , 2376-4791
    URL: Article
    DOI: 10.1177/0739532915577959
    RVK:
    AP 20628
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2068541-5
    SSG: 3,5
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