In:
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, The Royal Society, Vol. 380, No. 2220 ( 2022-04-04)
Kurzfassung:
In this paper, we present the prototype of an ophthalmoscope that uses structured illumination microscopy (SIM) to enable super-resolved imaging of the human retina, and give first insights into clinical application possibilities. The SIM technique was applied to build a prototype that uses the lens of the human eye as an objective to ‘super-resolve’ the retina of a living human. In our multidisciplinary collaboration, we have adapted this well-established technique in ophthalmology and successfully imaged a human retina using significantly lower light intensity than a state-of-the-art ophthalmoscope. Here, we focus on the technical implementation and highlight future perspectives of this method. A more application-oriented note for physicians on the diagnostic and disease-preventive value of this method, as well as the medical results of the clinical study carried out, will be published in a report addressed to an appropriate specialist audience. This article is part of the Theo Murphy meeting issue ‘Super-resolution structured illumination microscopy (part 2)’.
Materialart:
Online-Ressource
ISSN:
1364-503X
,
1471-2962
DOI:
10.1098/rsta.2021.0151
Sprache:
Englisch
Verlag:
The Royal Society
Publikationsdatum:
2022
ZDB Id:
208381-4
ZDB Id:
1462626-3
SSG:
11
SSG:
5,1
SSG:
5,21
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