Umfang:
Online-Ressource (XIII, 407 p. 47 illus., 38 illus. in color, online resource)
ISBN:
9781489980656
Serie:
SpringerLink
Inhalt:
miRNAs are a class of endogenous, small non-protein coding RNA molecules (approx. 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-ß and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Anmerkung:
Description based upon print version of record
,
Preface; Contents; Contributors; Part I; The Functions and Mechanisms of MicroRNAs; Chapter 1; miRNA Biogenesis and Function; 1 The Discovery of miRNAs; 2 Understanding miRNA Biogenesis; 2.1 Canonical miRNA Biogenesis: Dicer; 2.2 Canonical miRNA Biogenesis: Drosha; 2.3 Canonical miRNA Biogenesis: Nuclear Export; 2.4 Canonical miRNA Biogenesis: Transcription; 3 Noncanonical miRNA Biogenesis; 3.1 Microprocessor-Independent miRNA Biogenesis; 3.2 Dicer-Independent miRNA Biogenesis; 4 Regulation of miRNA Biogenesis; 5 Understanding miRNA Function; 5.1 Assembly of the RNA-Induced Silencing Complex
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Selection of the Functional miRNA Strand Canonical miRNA Target Recognition; 6 Noncanonical miRNA Target Recognition; 7 Mechanisms of miRNA-Mediated Gene Silencing; 8 Regulation of miRNA Function; 9 Conclusions; References; Chapter 2; MicroRNAs in Cancer Progression; 1 Cancer Overview; 2 miRNAs; 3 miRNAs as Oncogenes; 4 miRNAs as Tumor Suppressors; 5 miRNA Function in Hallmarks of Cancer; 6 miRNAs and Chemoresistance; 7 Therapeutic and Clinical Implications of miRNAs; 8 Conclusions and Future Perspectives; References; Chapter 3; MicroRNA, DNA Repair, and Cancer ; 1 Introduction
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2 MicroRNA Biogenesis, Regulation, and Cancer2.1 MiRNA Biogenesis: Core Components; 2.2 RNA Modifications; 2.3 Protein Modifications; 2.4 Protein-RNA Interactions; 2.5 Protein-Protein Interactions; 3 MicroRNAs in DNA Repair; 3.1 DNA Repair Mechanisms; 3.2 Core MMR Proteins-miR-155, miR-422a, miR-21; 3.3 NER Proteins-miR-192; 3.4 H2AX-miR-24, miR-138; 3.5 BRCA1-miR182, miR-146a; 3.6 ATM-miRNA421, miR-18a, miR-100, miR-101, miR-181; 3.7 Rad51-miR-96; 3.8 RAD52-miR-210, 373, miR-302; 4 miRNAs in Other DNA Damage Response Events; 5 Conclusions and Future Prospective; References; Part II
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MicroRNAs in Stem Cells and Progression of CancerChapter 4; Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila; 1 Introduction; 2 miRNAs in Stem Cell Regulation; 3 miRNAs in Drosophila GSCs: Self-Renewal and Differentiation; 3.1 miRNA and Female GSC ; 3.2 miRNAs and male GSC ; 4 miRNAs in Drosophila SSCs; 5 miRNAs in Tumorigenesis in Drosophila; 6 Conclusion; References; Chapter 5; MicroRNAs in Stem Cells and Cancer Stem Cells; 1 Introduction; 2 Stem Cells: Overview; 2.1 Discovery of Stem Cells; 2.2 Defining Stem Cells; 2.3 Sources of Stem Cells
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2.4 Niche in Stem Cell Regulation2.5 Self-Renewal and Differentiation of Stem Cells; 2.6 Stem Cell Quiescence; 3 Cancer Stem Cell; 3.1 The CSC hypothesis; 3.2 Emerging Evidence on the CSC Hypothesis; 3.3 Targeted Therapy for Stem-Like Cancer Cells; 4 MicroRNA; 5 Connexins; 6 Stromal Cell-Derived Factor 1/CXCL12; 6.1 Overview; 6.2 Emerging Role of CXCL12 in Cancer Biology; 6.3 CXCL12-CXCR4 Signaling Loops in Cancer; 6.4 CXCL12 in Tumor Dormancy: Pharmacological Targeting; 7 miRNA and CSC; 8 Conclusion; References; Chapter 6
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MicroRNAs in Epithelial Mesenchymal Transition and Breast Cancer Progression
Weitere Ausg.:
ISBN 9781489980649
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe MicroRNA in development and in the progression of cancer New York : Springer, 2014 ISBN 9781489980649
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
miRNS
;
Carcinogenese
;
miRNS
;
Krebs
;
Wachstum
;
miRNS
;
Carcinogenese
;
miRNS
;
Krebs
;
Wachstum
DOI:
10.1007/978-1-4899-8065-6
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