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  • 1
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 25, No. 4 ( 2019-04), p. 591-600
    Abstract: Obstetrical analgesia remains a matter of controversy because of the fear of neurotoxicity of local anesthetics on demyelinated fibers or their potential relationship with subsequent relapses. Objective: To assess the impact of neuraxial analgesia on the risk of relapse during the first 3 months post-partum, with a focus on women who experienced relapses during pregnancy. Methods: We analyzed data of women followed-up prospectively during their pregnancies and at least 3 months post-partum, collected in the Pregnancy in Multiple Sclerosis (PRIMS) and Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPARTMUS) studies between 1992–1995 and 2005–2012, respectively. The association of neuraxial analgesia with the occurrence of a post-partum relapse was estimated by logistic regression analysis. Results: A total of 389 women were included, 215 from PRIMS and 174 from POPARTMUS. In total, 156 women (40%) had neuraxial analgesia. Overall, 24% experienced a relapse during pregnancy and 25% in the 3 months post-partum. Women with a pregnancy relapse were more likely to have a post-partum relapse (odds ratio (OR) = 1.83, p = 0.02), independently of the use of neuraxial analgesia. There was no association between neuraxial analgesia and post-partum relapse (OR = 1.08, p = 0.78). Conclusion: Neuraxial analgesia was not associated with an increased risk of post-partum relapses, whatever multiple sclerosis (MS) activity during pregnancy.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2008225-3
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  • 2
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481989255-
    Abstract: Current guidelines recommend performing esophagectomy after endoscopic resection for early esophageal cancer when the risk of lymph node metastasis or residual cancer is found to be significant and endoscopic treatment is therefore noncurative. Our aim was to assess the safety and oncological outcomes of esophagogastric resection in this specific clinical setting. Patients and methods: A retrospective review from 2012 to 2018 was performed at four tertiary referral centers. All patients had a noncurative endoscopic resection of a clinical T1 esophageal cancer, followed by esophagectomy. Outcome measures were the rates of T0N0 specimens, overall survival, disease-free and cancer-specific survival, postoperative morbidity and mortality. Results: A total of 30 patients (13 with squamous cell carcinoma and 17 with adenocarcinoma) were included. The reasons for noncurative endoscopic resection were: positive vertical margins ( n = 12), squamous cell carcinoma with muscularis mucosae or submucosal layer invasion ( n = 3 and 9), adenocarcinoma with deep submucosal invasion ( n = 11), poorly differentiated tumor ( n = 6) and lymphovascular invasion ( n = 6). Overall, 63% of the esophagi were T0N0: most residual lesions were T1a metachronous lesions, and four (13%) patients had advanced pT status ( n = 3) or lymph node metastases ( n = 2). Overall survival, disease-free survival and cancer-specific survival were 83%, 75%, and 90% respectively. A total of 43% of patients had severe postoperative complications, and postoperative mortality was 7%. Conclusion: In this cohort, esophagectomy allowed the resection of residual advanced cancer or lymph node metastases in 13% of cases, at the cost of 43% severe morbidity and 7% mortality. Therefore, the possibility of close follow up needs to be balanced with a highly morbid surgical management in these patients.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  International Sociology Vol. 32, No. 5 ( 2017-09), p. 649-651
    In: International Sociology, SAGE Publications, Vol. 32, No. 5 ( 2017-09), p. 649-651
    Type of Medium: Online Resource
    ISSN: 0268-5809 , 1461-7242
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1481123-6
    detail.hit.zdb_id: 635273-X
    SSG: 2,1
    SSG: 3,4
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Biological Research For Nursing Vol. 21, No. 5 ( 2019-10), p. 485-494
    In: Biological Research For Nursing, SAGE Publications, Vol. 21, No. 5 ( 2019-10), p. 485-494
    Abstract: Oxidative stress is associated with poor perinatal outcomes. Little is known regarding the longitudinal levels of oxidative stress in the perinatal period or the correlation between maternal and neonatal oxidative stress levels. Objective: Describe and compare oxidative stress, specifically superoxide, superoxide dismutase, catalase, and glutathione levels, over the perinatal period. Study Design: Longitudinal descriptive design using a convenience sample of medically high- and low-risk pregnant women ( n = 140) from a maternal–fetal medicine and general obstetrics practice, respectively. Blood was obtained from women at 12–20 and 24–28 weeks’ gestation and during labor, from the umbilical cord at birth, and from neonates at 24–72 hr after birth. Levels of superoxide were measured using electron paramagnetic resonance (EPR) spectroscopy; antioxidants (superoxide dismutase, catalase, and glutathione) were measured using commercial assay kits. Relationships between oxidative stress levels at different time points were examined using nonparametric methods. Pregnancy outcome was collected. Results: Demographic variables, outcome variables, and oxidative stress levels in maternal blood, cord blood, and infants differed between medically high- and low-risk women. Descriptive patterns for oxidative stress measures varied over time and between risk groups. Significant correlations between time points were noted, suggesting intraindividual consistency may exist throughout the perinatal period. However, these correlations were not consistent across each medical risk group. Conclusion: EPR spectroscopy is a feasible method for the perinatal population. Results provide new information on perinatal circulating superoxide levels and warrant further investigation into potential relationships between prenatal and neonatal physiologic dysregulation of oxidative stress.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2070503-7
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Group Analysis Vol. 50, No. 1 ( 2017-03), p. 23-29
    In: Group Analysis, SAGE Publications, Vol. 50, No. 1 ( 2017-03), p. 23-29
    Type of Medium: Online Resource
    ISSN: 0533-3164 , 1461-717X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2034457-0
    SSG: 5,2
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  The ANNALS of the American Academy of Political and Social Science Vol. 665, No. 1 ( 2016-05), p. 171-194
    In: The ANNALS of the American Academy of Political and Social Science, SAGE Publications, Vol. 665, No. 1 ( 2016-05), p. 171-194
    Abstract: The prevalence of incarceration in the United States is increasingly well known. The prevalence of family involvement with child protective services (CPS) is less understood, though, and there is limited research examining links between incarceration and CPS involvement. Here, we describe the incidence and prevalence of incarceration and CPS involvement in the United States and outline reasons that the same individuals and families may be at risk for involvement in both systems. We then use unique longitudinal data from Wisconsin to describe intergenerational and intragenerational overlap in the two systems. Specifically, we calculate (1) the proportion of all CPS-involved children who have an incarcerated parent; (2) the proportion of incarcerated adults who have a CPS-involved child; (3) the proportion of incarcerated young men and women who were involved in the CPS system as adolescents; and (4) the proportion of CPS-involved adolescents who subsequently became incarcerated. We conclude with a discussion of directions for future research and implications for practice and policy.
    Type of Medium: Online Resource
    ISSN: 0002-7162 , 1552-3349
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2274940-8
    detail.hit.zdb_id: 757146-X
    detail.hit.zdb_id: 2097792-X
    detail.hit.zdb_id: 328-1
    SSG: 7,26
    SSG: 3,4
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  • 7
    In: Qualitative Health Research, SAGE Publications, Vol. 26, No. 1 ( 2016-01), p. 77-91
    Abstract: Transdisciplinarity (TD) is a participatory research approach in which actors from science and society work closely together. It offers means for promoting knowledge integration and finding solutions to complex societal problems, and can be applied within a multiplicity of epistemic systems. We conducted a TD process from 2011 to 2014 between indigenous Mayan medical specialists from Guatemala and Western biomedical physicians and scientists to study cancer. Given the immense cultural gap between the partners, it was necessary to develop new methods to overcome biases induced by ethnocentric behaviors and power differentials. This article describes this intercultural cooperation and presents a method of reciprocal reflexivity (Bidirectional Emic–Etic tool) developed to overcome them. As a result of application, researchers observed successful knowledge integration at the epistemic level, the social-organizational level, and the communicative level throughout the study. This approach may prove beneficial to others engaged in facilitating participatory health research in complex intercultural settings.
    Type of Medium: Online Resource
    ISSN: 1049-7323 , 1552-7557
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2010333-5
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  • 8
    In: The Counseling Psychologist, SAGE Publications, Vol. 46, No. 7 ( 2018-10), p. 821-845
    Abstract: The American Psychological Association’s “Guidelines for Clinical Supervision in Health Service Psychology,” as well as the extant supervision literature, focus on supervisees’ competencies in their roles as therapist–professionals, and on the competencies of clinical supervisors. We consider two questions: What are the implications of the Guidelines for health service psychology supervisees in their roles as supervisees (vs. as therapists)? How can supervisees empower themselves to be proactive in making effective use of clinical supervision? We then outline a competency-based approach by focusing on the knowledge, skills, and attitudes for supervisees in clinical supervision. We suggest that the competencies (knowledge, skills, and attitudes) required to be an effective supervisee are distinct from existing competencies that focus on the supervisee as a therapist–professional. Our intent is to delineate competency-based implications of the Guidelines for supervisees, as well as to educate and empower them to become proactive collaborators and participants in clinical supervision.
    Type of Medium: Online Resource
    ISSN: 0011-0000 , 1552-3861
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2056679-7
    SSG: 5,2
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Journal of Contemporary History Vol. 53, No. 3 ( 2018-07), p. 574-596
    In: Journal of Contemporary History, SAGE Publications, Vol. 53, No. 3 ( 2018-07), p. 574-596
    Abstract: The attitudes of British and German socialists vis-a-vis religion before the First World War has been described by one of the most eminent scholars in the field of the history of religion, Hugh McLeod, as being diametrically opposed – German socialists were largely secular, irreligious and anti-clerical whereas within British socialism, Christianity, especially dissenting Protestantism, was a far more important streak. In this article I would like to modulate the stark contrast contained in this commonly held view by looking at a slightly different time frame than McLeod, and by emphasizing more the ambiguities and uncertainties of that relationship between socialism and religion in both countries. It shall be argued that a longer-term positive relationship between religion and socialism in Britain can be juxtaposed with a rapprochement between the forces of religion and socialism in interwar Germany. Hence the article will provide a cross-country diachronic comparison of the relationship between religion and socialism in Britain and Germany. It will highlight, in particular, a common utopianism of religion and socialism, that could also be called utopianism of the social ethics of the Sermon on the Mount; attempts to forge socialism as new religion shall be examined on the subsequent pages.
    Type of Medium: Online Resource
    ISSN: 0022-0094 , 1461-7250
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1494064-4
    detail.hit.zdb_id: 3048-X
    SSG: 8
    SSG: 3,6
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Mathematics and Mechanics of Solids Vol. 21, No. 3 ( 2016-03), p. 295-304
    In: Mathematics and Mechanics of Solids, SAGE Publications, Vol. 21, No. 3 ( 2016-03), p. 295-304
    Abstract: This paper considers effective strain tensors within the context of linear elastic equilibrium theory. The elastic properties of structured materials are often averaged over subvolumes of various scales inside the material. For subvolumes smaller than a representative volume element, simple volume-averaging of the stress and strain may not preserve the elastic energy. We introduce an averaging process which preserves the energy for all boundary conditions. This averaging process emphasizes the parts of the material which carry the most stress. Here the effective strain is weighted by the local stress, and can be interpreted as an average strain over all paths taken by loads and forces through the volume. This alternative effective strain may be especially appropriate for materials with voids, such as foams and granular matter, as the averaging only involves the material itself. For uniform boundary conditions the weighted strain matches the volume-averaged strain. This paper investigates the properties of this weighted strain tensor. First, for each path taken by loads and forces through the volume we can measure a net length as well as a net extension due to the linear deformation. The weighted effective strain equals the ratio of average length to average extension, where the averaging is over all possible force paths. Thus this method provides a connection to load path analysis. Secondly, even when the average rotation within the subvolume is zero, there may be local fluctuations in the rotation field. These rotations can act like a mechanism, transferring elastic energy between boundaries or degrees of freedom. The effective strain defined here highlights this mechanism effect.
    Type of Medium: Online Resource
    ISSN: 1081-2865 , 1741-3028
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2046323-6
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