In:
ChemMedChem, Wiley, Vol. 1, No. 9 ( 2006-09-11), p. 909-909
Abstract:
The cover picture shows human MCF7 mammary adenocarcinoma cells, a cell line which has been used extensively to characterize tumor‐associated MUC1 glycoprotein. Cells were analysed by fluorescence‐activated cell sorting after being labelled with antibodies induced in mice by a synthetic glycopeptide construct (structure shown) in association with a mild adjuvant suitable for human therapy. This construct, composed of a universal T‐helper and three diversely glycosylated tumor‐related epitopes, was assembled using a convergent strategy based on two successive oxime ligations. It is the most immunogenic synthetic construct reported to date and is able to elicit antibodies that recognize tumor‐related MUC1 on MCF7 cells. (Thanks to T. Cantalupo for the image.) For more details, see the Communication by A. F. Delmas et al. on p. 965 ff.
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.200690032
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2209649-8
SSG:
15,3
Bookmarklink