In:
International Journal of Sports Medicine, Georg Thieme Verlag KG, Vol. 41, No. 13 ( 2020-10), p. 951-961
Abstract:
Exercise has been argued to improve cognitive function in both humans and
rodents. Angiogenesis significantly contributes to brain health, including cognition. The hippocampus is a crucial brain region for cognitive function.
However, studies quantifying the capillary changes in the hippocampus after running exercise are lacking. Moreover, the molecular details underlying the
effects of running exercise remain poorly understood. We show that endogenous nitric oxide contributes to the beneficial effects of running
exercise on cognition and hippocampal capillaries. Four weeks of running exercise significantly improved spatial memory ability and increased the
number of capillaries in the cornu ammonis 1 subfield and dentate gyrus of Sprague-Dawley rats. Running exercise also significantly increased nitric
oxide synthase activity and nitric oxide content in the rat hippocampus. After blocking the synthesis of endogenous nitric oxide by lateral
ventricular injection of NG-nitro-L-arginine methyl ester, a nonspecific nitric oxide synthase inhibitor, the protective effect of running exercise
on spatial memory was eliminated. The protective effect of running exercise on angiogenesis in the cornu ammonis 1 subfield and dentate gyrus of rats
was also absent after nitric oxide synthase inhibition. Therefore, during running excise, endogenous nitric oxide may contribute to regulating spatial
memory ability and angiogenesis in cornu ammonis 1 subfield and dentate gyrus of the hippocampus.
Type of Medium:
Online Resource
ISSN:
0172-4622
,
1439-3964
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2020
detail.hit.zdb_id:
2041541-2
SSG:
31
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