In:
Annals of the New York Academy of Sciences, Wiley, Vol. 876, No. 1 ( 1999-06), p. 229-235
Kurzfassung:
ABSTRACT: UK‐114 is a 14‐kDa ubiquitous protein recently sequenced by several groups throughout the world. Its activity ranges from being a tumor antigen, a protein synthesis inhibitor or a specific μ‐calpain activator. UK‐114 shows structural homologies also with proteins of the MHC‐1 binding proteins, and heat shock proteins (HSPs). We investigated the possible effects of UK‐114 on T helper cells cytokine profile and the development and progression of experimental autoimmune diseases. Homogeneous recombinant UK‐114 was used in all experiments. Treatment of Balb/c male mice for two weeks resulted in the increase of IL‐4, and the decrease of TNF‐α, IFN‐γ, and IL‐2 release from stimulated splenocytes, suggesting that UK‐114 modulates the Th1/Th2 cytokine profile toward Th2. Similar to that observed with HSP60/65, a single pretreatment of Lewis rats with UK‐114 significantly blunted the development of adjuvant‐induced arthritis, whereas chronic treatment of 4‐week‐old female NOD mice dose dependently inhibited the development of diabetes.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.1999.876.issue-1
DOI:
10.1111/j.1749-6632.1999.tb07643.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1999
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
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