In:
Annals of the New York Academy of Sciences, Wiley, Vol. 876, No. 1 ( 1999-06), p. 229-235
Abstract:
ABSTRACT: UK‐114 is a 14‐kDa ubiquitous protein recently sequenced by several groups throughout the world. Its activity ranges from being a tumor antigen, a protein synthesis inhibitor or a specific μ‐calpain activator. UK‐114 shows structural homologies also with proteins of the MHC‐1 binding proteins, and heat shock proteins (HSPs). We investigated the possible effects of UK‐114 on T helper cells cytokine profile and the development and progression of experimental autoimmune diseases. Homogeneous recombinant UK‐114 was used in all experiments. Treatment of Balb/c male mice for two weeks resulted in the increase of IL‐4, and the decrease of TNF‐α, IFN‐γ, and IL‐2 release from stimulated splenocytes, suggesting that UK‐114 modulates the Th1/Th2 cytokine profile toward Th2. Similar to that observed with HSP60/65, a single pretreatment of Lewis rats with UK‐114 significantly blunted the development of adjuvant‐induced arthritis, whereas chronic treatment of 4‐week‐old female NOD mice dose dependently inhibited the development of diabetes.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.1999.876.issue-1
DOI:
10.1111/j.1749-6632.1999.tb07643.x
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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