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  • Chemistry/Pharmacy  (9)
  • Comparative Studies. Non-European Languages/Literatures  (1)
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  • 1
    Book
    Book
    Recycling von Kunststoffen / (1994)
    Würzburg :Vogel,
    Details
    UID:
    almafu_BV009839378
    Format: 227 S. : Ill., graph. Darst.
    Edition: 1. Aufl.
    ISBN: 3-8023-1512-X
    Series Statement: Vogel-Fachbuch
    Language: German
    Subjects: Engineering , Chemistry/Pharmacy , Physics , Biology , General works
    RVK:
    AR 21680
    RVK:
    UV 9900
    RVK:
    VN 9450
    RVK:
    WK 5700
    RVK:
    ZM 5200
    Keywords: Kunststoffabfall ; Recycling ; Kunststoff ; Recycling
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  • 2
    Book
    Book
    Märchen aus Turkestan und Tibet / (1923)
    Jena :Diederichs,
    Details
    UID:
    almafu_BV026382733
    Format: 317 S. : , Ill.
    Edition: 1. - 6. Tsd.
    Series Statement: Die Märchen der Weltliteratur
    Language: German
    Subjects: Comparative Studies. Non-European Languages/Literatures
    RVK:
    ED 4250
    RVK:
    ED 4260
    Keywords: Märchen ; Anthologie ; Märchen ; Anthologie ; Anthologie
    Author information: Jungbauer, Gustav 1886-1942
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  • 3
    Online Resource
    Online Resource
    Protein chromatography : process development and scale-up (2020)
    Weinheim :Wiley-VCH,
    Details
    UID:
    almafu_9959359197102883
    Format: 1 online resource
    Edition: Second edition.
    ISBN: 9783527824021 , 3527824022 , 9783527824045 , 3527824049 , 9783527824038 , 3527824030
    Note: Previous edition: 2010. , 〈p〉Preface ix〈/p〉 〈p〉Nomenclature xiii〈/p〉 〈p〉〈b〉1 Downstream Processing of Biotechnology Products 〈/b〉〈b〉1〈/b〉〈/p〉 〈p〉1.1 Introduction 1〈/p〉 〈p〉1.2 Bioproducts and Their Contaminants 2〈/p〉 〈p〉1.2.1 Biomolecular Chemistry and Structure 2〈/p〉 〈p〉1.2.1.1 Proteins 2〈/p〉 〈p〉1.2.1.2 Primary Structure 3〈/p〉 〈p〉1.2.1.3 Secondary Structure 6〈/p〉 〈p〉1.2.1.4 Tertiary Structure 11〈/p〉 〈p〉1.2.1.5 Quaternary Structure 11〈/p〉 〈p〉1.2.1.6 Folding 12〈/p〉 〈p〉1.2.1.7 Post-translational Modifications 12〈/p〉 〈p〉1.2.1.8 Oligonucleotides and Polynucleotides 16〈/p〉 〈p〉1.2.1.9 Endotoxins 18〈/p〉 〈p〉1.2.2 Biochemical and Biophysical Properties 20〈/p〉 〈p〉1.2.2.1 UV Absorbance 20〈/p〉 〈p〉1.2.2.2 Size 22〈/p〉 〈p〉1.2.2.3 Charge 26〈/p〉 〈p〉1.2.2.4 Hydrophobicity 28〈/p〉 〈p〉1.2.2.5 Solubility 31〈/p〉 〈p〉1.2.2.6 Chemical Stability 33〈/p〉 〈p〉1.2.2.7 Mechanical Stability 34〈/p〉 〈p〉1.2.2.8 Viscosity 35〈/p〉 〈p〉1.2.2.9 Diffusivity 38〈/p〉 〈p〉1.3 Bioprocesses 40〈/p〉 〈p〉1.3.1 Expression Systems 40〈/p〉 〈p〉1.3.2 Host Cell Composition 43〈/p〉 〈p〉1.3.3 Culture Media 44〈/p〉 〈p〉1.3.4 Components of the Culture Broth 45〈/p〉 〈p〉1.3.5 Product Quality Requirements 46〈/p〉 〈p〉1.3.5.1 Types of Impurities 48〈/p〉 〈p〉1.3.5.2 Validation 50〈/p〉 〈p〉1.3.5.3 Purity Requirements 51〈/p〉 〈p〉1.4 Biosimilars 52〈/p〉 〈p〉1.5 Role of Chromatography in Downstream Processing 53〈/p〉 〈p〉1.6 Environmental Impact of Biopharmaceutical Manufacturing 59〈/p〉 〈p〉References 60〈/p〉 〈p〉〈b〉2 Introduction to Protein Chromatography 〈/b〉〈b〉63〈/b〉〈/p〉 〈p〉2.1 Introduction 63〈/p〉 〈p〉2.2 Basic Principles and Definitions 63〈/p〉 〈p〉2.3 Modes of Operation 67〈/p〉 〈p〉2.3.1 Elution Chromatography 69〈/p〉 〈p〉2.3.2 Frontal Analysis 70〈/p〉 〈p〉2.3.3 Displacement Chromatography 71〈/p〉 〈p〉2.3.4 Periodic Countercurrent and Simulated Moving Bed Separators (SMB) 72〈/p〉 〈p〉2.4 Performance Factors 76〈/p〉 〈p〉2.5 Separation Performance Metrics 81〈/p〉 〈p〉2.5.1 Column Efficiency 81〈/p〉 〈p〉2.5.2 Chromatographic Resolution 84〈/p〉 〈p〉2.5.3 Dynamic Binding Capacity 86〈/p〉 〈p〉2.5.4 Scaling Relationships 87〈/p〉 〈p〉References 90〈/p〉 〈p〉〈b〉3 Chromatography Media 〈/b〉〈b〉93〈/b〉〈/p〉 〈p〉3.1 Introduction 93〈/p〉 〈p〉3.2 Interaction Types and Chemistry 94〈/p〉 〈p〉3.2.1 Steric Interaction 94〈/p〉 〈p〉3.2.2 Hydrophobic Interaction 96〈/p〉 〈p〉3.2.3 Electrostatic Interaction 103〈/p〉 〈p〉3.2.4 Metal Ion Interaction 106〈/p〉 〈p〉3.2.5 Biospecific Interaction 108〈/p〉 〈p〉3.2.6 Mixed Mode Interaction 113〈/p〉 〈p〉3.3 Buffers and Mobile Phases 117〈/p〉 〈p〉3.4 Physical Structure and Properties 118〈/p〉 〈p〉3.4.1 Base Matrices 119〈/p〉 〈p〉3.4.1.1 Natural Carbohydrate Polymers 121〈/p〉 〈p〉3.4.1.2 Synthetic Polymers 122〈/p〉 〈p〉3.4.1.3 Inorganic Materials 123〈/p〉 〈p〉3.4.2 Porosity, Pore Size, and Surface Area 125〈/p〉 〈p〉3.4.3 Particle Size and Particle Size Distribution 131〈/p〉 〈p〉3.4.4 Mechanical and Flow Properties 132〈/p〉 〈p〉References 135〈/p〉 〈p〉〈b〉4 Laboratory and Process Columns and Equipment 〈/b〉〈b〉139〈/b〉〈/p〉 〈p〉4.1 Introduction 139〈/p〉 〈p〉4.2 Laboratory-Scale Systems 140〈/p〉 〈p〉4.2.1 Pumps 141〈/p〉 〈p〉4.2.2 Mixers 145〈/p〉 〈p〉4.2.3 Monitors 146〈/p〉 〈p〉4.2.4 System Volumes 149〈/p〉 〈p〉4.3 Process Columns and Equipment 150〈/p〉 〈p〉4.3.1 Columns 150〈/p〉 〈p〉4.3.2 Systems 155〈/p〉 〈p〉4.3.3 Column Packing 157〈/p〉 〈p〉References 158〈/p〉 〈p〉〈b〉5 Adsorption Equilibrium 〈/b〉〈b〉159〈/b〉〈/p〉 〈p〉5.1 Introduction 159〈/p〉 〈p〉5.2 Single-Component Systems 161〈/p〉 〈p〉5.3 Multicomponent Systems 174〈/p〉 〈p〉5.4 Empirical Correlation of Equilibrium Data 178〈/p〉 〈p〉5.5 Protein Conformational Changes upon Adsorption 180〈/p〉 〈p〉References 180〈/p〉 〈p〉〈b〉6 Rate Processes 〈/b〉〈b〉183〈/b〉〈/p〉 〈p〉6.1 Introduction 183〈/p〉 〈p〉6.2 Rate Mechanisms 183〈/p〉 〈p〉6.2.1 External Mass Transfer 185〈/p〉 〈p〉6.2.2 Pore Diffusion 188〈/p〉 〈p〉6.2.3 Solid Diffusion 192〈/p〉 〈p〉6.2.4 Intraparticle Convection 196〈/p〉 〈p〉6.2.5 Kinetic Resistance to Binding 201〈/p〉 〈p〉6.3 Batch Adsorption Kinetics 202〈/p〉 〈p〉6.3.1 General Rate Equations 204〈/p〉 〈p〉6.3.2 Analytical Solutions 206〈/p〉 〈p〉6.3.2.1 External Mass Transfer Control 207〈/p〉 〈p〉6.3.2.2 Solid Diffusion Control 207〈/p〉 〈p〉6.3.2.3 Pore Diffusion Control 208〈/p〉 〈p〉6.3.2.4 Binding Kinetics Control 210〈/p〉 〈p〉6.3.2.5 LDF Solution 210〈/p〉 〈p〉6.3.2.6 Combined Mass Transfer Resistances 211〈/p〉 〈p〉6.3.3 Experimental Verification of Transport Mechanisms 214〈/p〉 〈p〉6.3.4 Multicomponent Protein Adsorption Kinetics 218〈/p〉 〈p〉References 223〈/p〉 〈p〉〈b〉7 Dynamics of Chromatography Columns 〈/b〉〈b〉227〈/b〉〈/p〉 〈p〉7.1 Introduction 227〈/p〉 〈p〉7.2 Material Balance Equations 227〈/p〉 〈p〉7.2.1 Boundary Conditions 229〈/p〉 〈p〉7.2.2 Dimensionless Equations 230〈/p〉 〈p〉7.3 Local Equilibrium Dynamics 231〈/p〉 〈p〉7.4 Multicomponent Systems 244〈/p〉 〈p〉7.5 Displacement Chromatography 256〈/p〉 〈p〉7.5.1 Prediction of the Isotachic Train 257〈/p〉 〈p〉7.5.2 Transient Development 262〈/p〉 〈p〉References 263〈/p〉 〈p〉〈b〉8 Effects of Dispersion and Rate Processes on Column Performance 〈/b〉〈b〉265〈/b〉〈/p〉 〈p〉8.1 Introduction 265〈/p〉 〈p〉8.2 Empirical Characterization of Column Efficiency 265〈/p〉 〈p〉8.3 Modeling and Prediction of Column Efficiency 275〈/p〉 〈p〉8.3.1 Plate Model 275〈/p〉 〈p〉8.3.2 Rate Models with Linear Isotherms 278〈/p〉 〈p〉8.3.3 Rate Models with Nonlinear Isotherms 287〈/p〉 〈p〉8.3.4 Rate Models for Competitive Adsorption Systems 303〈/p〉 〈p〉References 308〈/p〉 〈p〉〈b〉9 Gradient Elution Chromatography 〈/b〉〈b〉311〈/b〉〈/p〉 〈p〉9.1 Introduction 311〈/p〉 〈p〉9.2 General Theory for Gradient Elution with Linear Isotherms 313〈/p〉 〈p〉9.3 LGE Relationships and the Iso-resolution Curve in IEC 320〈/p〉 〈p〉9.3.1 Iso-resolution Curve 329〈/p〉 〈p〉9.4 LGE Relationships for RPC and HIC 332〈/p〉 〈p〉9.5 Gradient Elution at High Protein Loads 337〈/p〉 〈p〉9.6 Separations with pH Gradients 339〈/p〉 〈p〉References 351〈/p〉 〈p〉〈b〉10 Chromatographic Column Design and Optimization 〈/b〉〈b〉355〈/b〉〈/p〉 〈p〉10.1 Introduction 355〈/p〉 〈p〉10.2 Chromatographic Process Steps and Constraints 357〈/p〉 〈p〉10.3 Design for Capture 361〈/p〉 〈p〉10.3.1 Load Step 362〈/p〉 〈p〉10.3.2 Wash Step 363〈/p〉 〈p〉10.3.3 Elution Step 364〈/p〉 〈p〉10.3.4 CIP Step 364〈/p〉 〈p〉10.3.5 Re-equilibration Step 365〈/p〉 〈p〉10.3.6 Productivity and Capacity Utilization 365〈/p〉 〈p〉10.3.7 Continuous Capture 370〈/p〉 〈p〉10.4 Design for Chromatographic Resolution 375〈/p〉 〈p〉10.5 SMB Design 382〈/p〉 〈p〉References 391〈/p〉 〈p〉Index 395〈/p〉
    Additional Edition: Print version : ISBN 9783527346660
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    VG 7200
    RVK:
    VG 7201
    RVK:
    WC 3480
    Keywords: Electronic books. ; Lehrbuch ; Electronic books. ; Electronic books.
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527824045
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527824045
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527824045
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  • 4
    Book
    Book
    Protein chromatography : process development and scale-up (2020)
    Weinheim :Wiley-VCH,
    Details
    UID:
    almahu_BV046807488
    Format: xvii, 406 Seiten : , Illustrationen, Diagramme ; , 24.4 cm x 17 cm.
    Edition: Second edition
    ISBN: 978-3-527-34666-0 , 3-527-34666-X
    Additional Edition: Erscheint auch als Online-Ausgabe, PDF ISBN 978-3-527-82403-8
    Additional Edition: Erscheint auch als Online-Ausgabe, EPUB ISBN 978-3-527-82402-1
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-527-82404-5
    Former: Vorangegangen ist
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    WC 3480
    RVK:
    VG 7200
    RVK:
    VG 7201
    Keywords: Proteine ; Chromatographie ; Pharmazeutische Industrie ; Lehrbuch ; Lehrbuch
    URL: http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34666-0/
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032216114&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    URL: http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34666-0/
    URL: Buchcover
    Author information: Jungbauer, Alois, 1956-
    Author information: Carta, Giorgio
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  • 5
    Book
    Book
    Meßverfahren im Chemie- und Biologieunterricht : Eine Zsstellung für d. Kollegstufe. (1980)
    Köln :Deubner,
    Details
    UID:
    almafu_BV002246818
    Format: 107 S.: graph.Darst.
    ISBN: 3-7614-0467-0
    Series Statement: Praxis-Schriftenreihe / Abt. Chemie. 34.
    Language: German
    Subjects: Chemistry/Pharmacy
    RVK:
    VB 4045
    RVK:
    VC 2000
    Keywords: Biologie ; Experiment ; Unterricht ; Experiment ; Naturwissenschaften ; Unterricht ; Biologieunterricht ; Messung ; Chemieunterricht ; Messung
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  • 6
    Online Resource
    Online Resource
    Protein chromatography : process development and scale-up (2010)
    Weinheim :Wiley-VCH ;
    Details
    UID:
    almafu_9959328456802883
    Format: 1 online resource
    ISBN: 9783527630158 , 3527630155
    Note: English.
    Additional Edition: Print version: Carta, Giorgio. Protein chromatography. Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2010 ISBN 9783527318193
    Additional Edition: ISBN 3527318194
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    WC 3480
    RVK:
    VG 7200
    RVK:
    WD 5100
    RVK:
    VN 8930
    Keywords: Electronic books. ; Electronic books.
    DOI: 10.1002/9783527630158
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630158
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630158
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  • 7
    Book
    Book
    Protein chromatography : process development and scale-up (2010)
    Weinheim : Wiley-VCH-Verl.
    Details
    UID:
    gbv_611753782
    Format: XVII, 346 S. , Ill., graph. Darst. , 25 cm
    ISBN: 9783527318193
    Note: Literaturangaben , Downstream processing of biotechnology products -- Introduction to protein chromatography -- Chromatography media -- Laboratory and process columns and equipment -- Adsorption equilibria -- Adsorption kinetics -- Dynamics of chromatography columns -- Effects of dispersion and adsorption kinetics on column performance -- Gradient elution chromatography -- Design of chromatographic processes.
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    VG 7200
    RVK:
    WC 3480
    Keywords: Proteine ; Chromatographie
    URL: Inhaltstext
    URL: Cover
    URL: Inhaltsverzeichnis
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  • 8
    Book
    Book
    Protein Chromatography : Process Development and Scale-Up (2010)
    Weinheim :Wiley-VCH,
    Details
    UID:
    almafu_BV036129371
    Format: XVII, 346 S. : , Ill., graph. Darst.
    ISBN: 978-3-527-31819-3
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    VG 7200
    RVK:
    VG 7201
    RVK:
    WC 3480
    Keywords: Proteine ; Chromatographie ; Pharmazeutische Industrie
    URL: Inhaltstext
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  • 9
    Loose Leaf
    Loose Leaf
    Meßverfahren im Chemie- und Biologieunterricht : Eine Zsstellung für d. Kollegstufe (1980)
    Köln : Deubner
    Details
    UID:
    b3kat_BV002246818
    Format: 107 S.: graph.Darst.
    ISBN: 3761404670
    Series Statement: Praxis-Schriftenreihe / Abt. Chemie. 34.
    Language: German
    Subjects: Chemistry/Pharmacy
    RVK:
    VB 4045
    RVK:
    VC 2000
    Keywords: Biologie ; Experiment ; Unterricht ; Experiment ; Naturwissenschaften ; Unterricht ; Biologieunterricht ; Messung ; Chemieunterricht ; Messung
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  • 10
    Book
    Book
    Protein Chromatography : Process Development and Scale-Up (2010)
    Weinheim : Wiley-VCH
    Details
    UID:
    b3kat_BV036129371
    Format: XVII, 346 S. , Ill., graph. Darst.
    ISBN: 9783527318193
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
    RVK:
    VG 7200
    RVK:
    VG 7201
    RVK:
    WC 3480
    Keywords: Proteine ; Chromatographie ; Pharmazeutische Industrie
    URL: Inhaltstext
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