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Consortium
  • 1
    Book
    Book
    Ann Arbor : The University of Michigan Press
    UID:
    (DE-627)1610239202
    Format: xvi, 222 Seiten , map , 24 cm
    ISBN: 0472098098 , 0472068091
    Note: Includes bibliographical references (p. [185]-220) and index
    Language: English
    Subjects: Sociology
    RVK:
    Keywords: China ; Volkskunde ; China ; Selbst
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  • 2
    Book
    Book
    Ann Arbor : The University of Michigan Press
    UID:
    (DE-602)gbv_1610239202
    Format: xvi, 222 Seiten , map , 24 cm
    ISBN: 0472098098 , 0472068091
    Note: Includes bibliographical references (p. [185]-220) and index
    Language: English
    Subjects: Sociology
    RVK:
    Keywords: China ; Volkskunde ; China ; Selbst
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : eScholarship, University of California
    UID:
    (DE-627)1803297794
    Content: The immune system is essential for host defense to pathogen infection, tissue repair, stress response, and other physiological functions. An unbalanced immune system is detrimental to homeostasis and mammalian survival. Immunodeficiency can cause susceptibility to pathogen infection. A hyperactive immune system can cause autoimmunity and chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and atherosclerosis. Deciphering the mechanisms regulating the immune response will illuminate on the pathogenesis of inflammatory diseases and promote the development of new therapies to treat these diseases. Because innate immunity is the first line of host defense and transcription is a critical contributor to the innate immune response, we focused our studies on mechanisms regulating transcriptional activation of the innate immune response. Toll-like receptor (TLR) signaling is a classical model to study pathogen recognition and the activation of innate immunity. TLR transcriptional cascades have been extensively studied using conventional systems approaches. Because conventional systems approaches rely on statistics and large sample sizes to uncover the common regulatory mechanisms, they often miss gene-specific regulatory mechanisms. To reveal gene-specific regulatory mechanisms, we used a stringent systems approach to dissect the TLR transcriptional cascades in chapter 2. To prevent biases towards the majority of weakly induced genes, we separated strongly induced genes from weakly induced genes. Combining high-resolution transcriptional profiles and perturbation studies, we classified TLR4-activated genes by their activation mechanisms. By integrating RNA-seq, ChIP-seq, ATAC-seq, and motif data, we found that several key inflammatory genes are regulated by highly selective mechanisms. TLR4-activated nuclear factor kappa B (NFκB) and interferon regulatory factor 3 (IRF3) selectively regulate a small subset of pro-inflammatory genes by chromatin and combinatorial regulation. We also found serum response factor (SRF) selectively regulates a few early transient primary response genes. In chapter 3, we used a gene-centric method and identified the motif rules governing the combinatorial regulation of serum response factor (SRF) and ternary complex factor (TCF). Ternary complex formation can enhance SRF binding and promote histone mark deposition. The active ternary complex can regulate transcription through either promoter or enhancer. Taken together, we demonstrated a gene-centric, stringent systems approach that can complement the conventional systems approach to unveil gene-specific regulatory mechanisms in ligand-induced transcriptional cascades.
    Note: Dissertation eScholarship, University of California 2017
    Language: English
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  • 4
    UID:
    (DE-101)982697902
    Format: Online-Ressource
    Note: Oldenburg, Univ., Diss., 2006
    Additional Edition: Druckausg. Liu, Xin, 1976- Developing and testing integrated decision support models for coastal management
    Language: English
    Keywords: Hochschulschrift
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  • 5
    Book
    Book
    Ostfildern : Hatje Cantz
    UID:
    (DE-603)19741480X
    Format: 109 S. , Ill.
    ISBN: 9783775721479
    Language: English
    Subjects: Engineering , Art History
    RVK:
    RVK:
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  • 6
    Book
    Book
    Ann Arbor : Univ. of Michigan Press
    UID:
    (DE-603)106478184
    Format: XVI, 222 Seiten , Karten
    ISBN: 0472098098
    Note: Literaturverzeichnis Seite 209-220
    Language: English
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  • 7
    UID:
    (DE-603)380284294
    Note: Bachelorarbeit Technische Universität Darmstadt 2011
    Language: German
    Keywords: Hochschulschrift
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  • 8
    Online Resource
    Online Resource
    CRC Press
    UID:
    (DE-605)HT021792540
    Format: 1 Online-Ressource
    ISBN: 9780429159480
    Additional Edition: 9781482226669
    Language: Undetermined
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  • 9
    Book
    Book
    London ; New York : Routledge, Taylor & Francis Group
    UID:
    (DE-604)BV046260354
    Format: xii, 260 Seiten , Illustrationen, Diagramme
    ISBN: 9780367281533
    Series Statement: Routledge new diplomacy studies
    Content: "This book examines China's contemporary global cultural footprints through its recent development of cultural diplomacy. The volume presents an alternative analytical framework to examine China's cultural diplomacy which goes beyond the Western-defined concept of 'soft power' that prevails in the current literature. This new approach constructs a three-dimensional framework on Orientalism, cultural hegemony, and nationalism to decipher the multiple contexts which China inhabits historically, internationally and domestically. The book presents multiple case studies of the Confucius Institute, and compares the global program located around the world with its Western counterparts, and also with other Chinese government-sponsored endeavours and non-government-initiated programs. The author aims to solve the puzzle of why China's efforts in cultural diplomacy are perceived differently around the world and helps to outline the distinctive features of China's cultural diplomacy. This book will be of much interest to students of diplomacy, Chinese politics, foreign policy and International Relations in general"--
    Note: Look beyone and beneath the soft power -- The vehicle and driver of China's cultural diplomacy : the Two "Wheels" and Two Models -- Charting the global cultural terrain of struggle for China's Confucius Institutes -- So similar, so different, so Chinese : analytical comparisons of the Confucius Institute with its Western counterparts -- The last three feet : where citizen diplomacy can dissolve the perception of Chinese sharp power -- Cultural diplomacy with Chinese characteristics -- Conclusion
    Additional Edition: Erscheint auch als Online-Ausgabe, ebk ISBN 978-0-429-32029-3
    Language: English
    Subjects: Political Science
    RVK:
    Keywords: China ; Konfuzius-Institut ; Auswärtige Kulturpolitik
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  • 10
    Online Resource
    Online Resource
    New York, NY :Routledge,
    UID:
    (DE-602)almahu_9949385843302882
    Format: 1 online resource
    ISBN: 9781000637601 , 1000637603 , 9781003156383 , 100315638X , 9781000637564 , 1000637565
    Series Statement: Routledge Studies in Modern History
    Content: Anglo-Chinese Encounters Before the Opium War: A Tale of Two Empires Over Two Centuries studies the fascinating encounters between the two historic empires from Queen Elizabeth I's first letter to the Ming Emperor Wanli in 1583, to Lord Palmerston's letter to the Minister of China in 1840. Starting with Queen Elizabeth I's letter to the Chinese Emperor and ending with the letter from Lord Palmerston to the Minister of China just before the Opium War, this book explores the long journey in between from cultural diplomacy to gunboat diplomacy. It interweaves the most known diplomatic efforts at the official level with the much unknown intellectual interactions at the people-to-people level, from missionaries to scholars, from merchants to travelers and from artists to scientists. This book adopts a novel "mirror" approach by pairing and comparing people, texts, commodities, artworks, architecture, ideologies, operating systems and world views of the two empires. Using letters, gifts and traded goods as fulcrums, and by adopting these unique lenses, it puts China into the world history narratives to contextualise Anglo-Chinese relations, thus providing a fresh analysis of the surviving evidence. Xin Liu casts a new light on understanding the Sino-centric and Anglo-centric world views in driving the complex relations between the two empires, and the reversals of power shifts that are still unfolding today. The book is not intended for specialists in history, but a general audience wishing to learn more about China's historical engagement with the world.
    Additional Edition: Print version: ISBN 0367741679
    Additional Edition: ISBN 9780367741679
    Language: English
    Keywords: Electronic books.
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