In:
Infection and Immunity, American Society for Microbiology, Vol. 71, No. 12 ( 2003-12), p. 7178-7182
Abstract:
An
intact Haemophilus ducreyi flp operon is essential for
microcolony formation in vitro. tadA is the 9th of 15 genes in
the operon and has homology to NTPases of type IV secretion systems. Fifteen human volunteers were experimentally infected with both H.
ducreyi 35000HP and the tadA mutant, 35000HP.400. Papules
developed at similar rates at sites inoculated with the mutant and parent, while pustules formed at 36.4% of parent sites and at
0% of mutant sites ( P = 0.001). Compared to
35000HP, 35000HP.400 had only a modest but significant reduction in lesion scores in the temperature-dependent rabbit model of chancroid.
These data suggest that proteins secreted by the flp locus are
required for full expression of virulence by H. ducreyi in
humans but have less of a role in virulence in an animal model of infection.
Type of Medium:
Online Resource
ISSN:
0019-9567
,
1098-5522
DOI:
10.1128/IAI.71.12.7178-7182.2003
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2003
detail.hit.zdb_id:
1483247-1
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