Kooperativer Bibliotheksverbund

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Format: 135 S. : , Ill., graph. Darst.

ISBN: 3-8017-1703-8

Series Statement: Therapeutische Praxis

Language: German

Subjects: Psychology

Keywords: Kognitive Verhaltenstherapie

URL: Inhaltsverzeichnis

URL: Inhaltsverzeichnis

URL: Inhaltsverzeichnis

Author information: Müller, Sandra Verena 1967-

Author information: Münte, Thomas Frank 1960-

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Format: 192 S. : überw. Ill. : 24 cm.

Edition: 19. Aufl.

ISBN: 3-922484-38-7

Note: Text dt., engl. und franz.

Language: German

Subjects: History , Political Science

Keywords: Geschichte ; Ausstellungskatalog ; Ausstellungskatalog ; Ausstellungskatalog ; Ausstellung ; Ausstellungskatalog

Author information: Hildebrandt, Rainer 1914-2004

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Format: XI, 120 S. : zahlr. Ill.

ISBN: 3-540-66477-7

Language: German

Subjects: Medicine

Keywords: Wirbelsäule ; Minimal-invasive Chirurgie

URL: Inhaltsverzeichnis

Author information: Hildebrandt, Ulrich 1949-

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Format: XIII, 309 S. : Ill., graph. Darst.

Edition: 2., vollst. überarb. Aufl.

ISBN: 3-540-41922-5

Language: German

Subjects: Medicine

Keywords: Schmerztherapie ; Neurochirurgie ; Schmerztherapie ; Neurektomie ; Aufsatzsammlung

URL: Inhaltsverzeichnis

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Format: 1 Online-Ressource (396 S.).

Note: Berlin, Freie Univ., Diss., 2001

Language: German

Subjects: Political Science

Keywords: Legitimität ; Politische Krise ; Internationalisierung ; Sozioökonomischer Wandel ; Agrarweltmarkt ; Internationalisierung ; Ländlicher Raum ; Sozioökonomischer Wandel ; Landwirtschaft ; Freihandel ; Kommunalpolitik ; Legitimität ; Wirtschaftliche Integration ; Neoliberalismus ; Politisches System ; Legitimität ; Hochschulschrift

URL: Volltext  (lizenzfrei)

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Format: 1 Online-Ressource (79 Bl.) : , Ill., graph. Darst.

Note: Nebentitel: The m2 muscarinic receptor and its involvement in the regulation of trabecular meshwork and ciliary muscle contractility , Berlin, Freie Univ., Diss., 2004

Language: German

Keywords: Hochschulschrift

URL: Volltext  (lizenzfrei)

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Format: 1 online resource (719 p.)

ISBN: 0-08-088422-9

Series Statement: Methods in enzymology ; volume 343

Content: G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each

Note: Description based upon print version of record. , Front Cover; G Protein Pathways; Copyright Page; Table of Contents; Contributors to Volume 343; Preface; Volume in Series; Section I: G Protein-Coupled Receptors; A. Theoretical Evaluation of Receptor Function; B. Design and Use of Receptor Ligands; C. Structural Characterization of Receptor Proteins; D. Design and Use of Engineered Receptor Proteins; E. Molecular Modeling Studies of Receptor Structure and Function; F. Analysis of Receptor Protein Coupling; G. Characterization of Receptor Heterogeneity; H. The Study of Receptor Trafficking , Chapter 1. Considerations in the Evaluation of Inverse Agonism and Protean Agonism at GProtein-Coupled ReceptorsChapter 2. Theoretical Implications of Receptor Coupling to Multiple G Proteins Based on Analysis of Three-State Model; Chapter 3. Use of Retinal Analogues for the Study of Visual Pigment Function; Chapter 4. Design and Synthesis of Peptide Antagonists and Inverse Agonists for G Protein-Coupled Receptors; Chapter 5. Design of Peptide Agonists; Chapter 6. Design of Nonpeptides from Peptide Ligands for Peptide Receptors , Chapter 7. Strategies for Mapping the Binding Site of the Serotonin 5-HT2A ReceptorChapter 8. Use of the Substituted Cysteine Accessibility Method to Study the Structure and Function of G Protein-Coupled Receptors; Chapter 9. Mass Spectrometric Analysis of GProtein-Coupled Receptors; Chapter 10. Probing the Higher Order Sructure of G Protein- Coupled Receptors Using Tethered Cleavage Methods; Chapter 11. Use of Fluorescence Spectroscopy to Study Conformational Changes in the β2-Adrenoceptor; Chapter 12. Crystallization of Membrane Proteins in Cubo , Chapter 13. N-Linked Carbohydrates on G Protein-Coupled Receptors: Mapping Sites of Attachment and Determining Functional RolesChapter 14. Magic Angle Spinning Nuclear Magnetic Resonance of Isotopically Labeled Rhodopsin; Chapter 15. Use of Nuclear Magnetic Resonance to Study the Three-Dimensional Structure of Rhodopsin; Chapter 16. Tools for Dissecting Signaling Pathways in Vivo: Receptors Activated Solely by Synthetic Ligands; Chapter 17. Analysis of Structure-Function from Expression of G Protein-Coupled Receptor Fragments , Chapter 18. Construction and Analysis of Function of G Protein-Coupled Receptor-G Protein Fusion ProteinsChapter 19. Synthetic Gene Technology: Applications to Ancestral Gene Reconstruction and Structure Function Studies of Receptors; Chapter 20. Considerations in the Design and Use of Chimeric G Protein-Coupled Receptors ; Chapter 21. Strategies for Modeling the Interactions of Transmembrane Helices of G Protein-Coupled Receptors by Geometric Complementarity Using the GRAMM Computer Algorithm , Chapter 22. Three-Dimensional Representations of G Protein- Coupled Receptor Structures and Mechanisms , English

Additional Edition: ISBN 1-322-20131-5

Additional Edition: ISBN 0-12-182244-3

Language: English

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Format: 1 online resource (695 p.)

ISBN: 1-281-01122-3 , 9786611011222 , 0-08-049693-8

Content: This third volume in the trio covering G proteins, features integrated approaches to studying G proteins. Methods pertaining to signaling mechanisms are presented, including theoretical and modeling approaches, biochemistry and molecular biology, and cell biology and physiology. The techniques for studying the structure and function of G proteins are important not only to those with specific research interests in them, but also endocrinologists and pharmacologists conducting research on signaling mechanisms that are increasingly understood to interact with G proteins.

Note: Description based upon print version of record. , Front Cover; G Protein Pathways; Copyright Page; Table of Contents; Contributors to Volume 345; Preface; Volume in Series; Section I: Modeling Intracellular Signaling Pathways; Chapter 1. Use of Kinetikit and GENESIS for Modeling Signaling Pathways; Section II: Phosphodiesterases; Chapter 2. Assays of G Protein/cGMP-Phosphodiesterase Interactions; Chapter 3. Assaying G Protein-Phosphodiesterase Interactions in Sensory Systems; Section III: Calcium and Potassium Channels; Chapter 4. Studies of Endogenous G-Protein-Mediated Pathways in Neurons by Whole-Cell Electrophysiology , Chapter 5. Biochemical Approaches to Study Interaction of Calcium Channels with RGS12 in Primary Neuronal CulturesChapter 6. Assaying Phosphatidylinositol Bisphosphate Regulation of Potassium Channels; Section IV: Adenylyl Cyclases; Chapter 7. Purification of Soluble Adenylyl Cyclase; Chapter 8. Calcium-Sensitive Adenylyl Cyclase/Aequorin Chimeras as Sensitive Probes for Discrete Modes of Elevation of Cytosolic Calcium; Chapter 9. Kinetic Analysis of the Action of P-Site Analogs , Chapter 10. Expression, Purification, and Assay of Cytosolic (Catalytic) Domains of Membrane-Bound Mammalian Adenylyl CyclasesChapter 11. Identification of Putative Direct Effectors for Gαo, Using Yeast Two-Hybrid Method; Chapter 12. Identification of Transmembrane Adenylyl Cyclase Isoforms; Chapter 13. Functional Analyses of Type V Adenylyl Cyclase; Chapter 14. Photoaffinity Labeling of Adenylyl Cyclase; Chapter 15. Crystallization of Complex between Soluble Domains of Adenylyl Cyclase and Activated Gsα; Chapter 16. Generation of Adenylyl Cyclase Knockout Mice , Chapter 17. Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl CyclaseChapter 18. Genetic Selection of Regulatory Mutants of Mammalian Adenylyl Cyclases; Section V: Phospholipases and Lipid-Derived Products; Chapter 19. Expression and Characterization of Rat Brain Phospholipase D; Chapter 20. G-Protein-Coupled Receptor Regulation of Phospholipase D; Chapter 21. Analysis and Quantitation of Ceramide; Chapter 22. Assays for Phospholipase D Reaction Products , Chapter 23. Determination of Strength and Specificity of Membrane-Bound G Protein-Phospholipase C Association Using Fluorescence SpectroscopyChapter 24. Assays and Characterization of Mammalian Phosphatidylinositol 4,5-Bisphosphate-Sensitive Phospholipase D; Chapter 25. Characterization and Purification of Phosphatidylinositol Trisphosphate 5-Phosphatase from Rat Brain Tissues; Section VI: Small GTP-Binding Proteins; Chapter 26. Assay of Cdc42, Rac, and Rho GTPase Activation by Affinity Methods; Chapter 27. Assays of ADP-Ribosylation Factor Function , Chapter 28. Functional Characterization of p115 RhoGEF , English

Additional Edition: ISBN 0-12-182246-X

Language: English

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Format: 1 online resource (719 p.)

ISBN: 1-281-01121-5 , 9786611011215 , 0-08-049692-X

Series Statement: Methods in enzymology, v. 343

Content: This volume covers topics such as the structure and identification of functional domains of G proteins, and activation of G proteins by receptors or other regulators. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the mo

Note: Description based upon print version of record. , Front Cover; G Protein Pathways; Copyright Page; Table of Contents; Contributors to Volume 343; Preface; Volume in Series; Section I: G Protein-Coupled Receptors; A. Theoretical Evaluation of Receptor Function; Chapter 1. Considerations in the Evaluation of Inverse Agonism and Protean Agonism at GProtein-Coupled Receptors; Chapter 2. Theoretical Implications of Receptor Coupling to Multiple G Proteins Based on Analysis of Three-State Model; B. Design and Use of Receptor Ligands; Chapter 3. Use of Retinal Analogues for the Study of Visual Pigment Function , Chapter 4. Design and Synthesis of Peptide Antagonists and Inverse Agonists for G Protein-Coupled ReceptorsChapter 5. Design of Peptide Agonists; Chapter 6. Design of Nonpeptides from Peptide Ligands for Peptide Receptors; Chapter 7. Strategies for Mapping the Binding Site of the Serotonin 5-HT2A Receptor; C. Structural Characterization of Receptor Proteins; Chapter 8. Use of the Substituted Cysteine Accessibility Method to Study the Structure and Function of G Protein-Coupled Receptors; Chapter 9. Mass Spectrometric Analysis of GProtein-Coupled Receptors , Chapter 10. Probing the Higher Order Sructure of G Protein- Coupled Receptors Using Tethered Cleavage MethodsChapter 11. Use of Fluorescence Spectroscopy to Study Conformational Changes in the ß2-Adrenoceptor; Chapter 12. Crystallization of Membrane Proteins in Cubo; Chapter 13. N-Linked Carbohydrates on G Protein-Coupled Receptors: Mapping Sites of Attachment and Determining Functional Roles; Chapter 14. Magic Angle Spinning Nuclear Magnetic Resonance of Isotopically Labeled Rhodopsin; Chapter 15. Use of Nuclear Magnetic Resonance to Study the Three-Dimensional Structure of Rhodopsin , D. Design and Use of Engineered Receptor ProteinsChapter 16. Tools for Dissecting Signaling Pathways in Vivo: Receptors Activated Solely by Synthetic Ligands; Chapter 17. Analysis of Structure-Function from Expression of G Protein-Coupled Receptor Fragments; Chapter 18. Construction and Analysis of Function of G Protein-Coupled Receptor-G Protein Fusion Proteins; Chapter 19. Synthetic Gene Technology: Applications to Ancestral Gene Reconstruction and Structure Function Studies of Receptors; Chapter 20. Considerations in the Design and Use of Chimeric G Protein-Coupled Receptors , E. Molecular Modeling Studies of Receptor Structure and FunctionChapter 21. Strategies for Modeling the Interactions of Transmembrane Helices of G Protein-Coupled Receptors by Geometric Complementarity Using the GRAMM Computer Algorithm; Chapter 22. Three-Dimensional Representations of G Protein- Coupled Receptor Structures and Mechanisms; F. Analysis of Receptor Protein Coupling; Chapter 23. Reconstitution of G Protein-Coupled Receptors with Recombinant GProteinaand ß? Subunits; Chapter 24. Cell-Free Membrane Desensitization Assay for G Protein-Coupled Receptors , Chapter 25. Methods to Determine the Constitutive Activity of Histamine H2 Receptors , English

Additional Edition: ISBN 0-12-182245-1

Language: English