In:
FEBS Letters, Wiley, Vol. 417, No. 3 ( 1997-11-17), p. 301-306
Kurzfassung:
The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B‐lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T‐lymphocytes. Activation of T‐lymphocytes via gp39/CD40L induced a strong activation of Jun‐N‐terminal kinase (JNK) and p38‐K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38‐K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56 lck . Inhibition of src‐like kinases inhibits Rac1 as well as JNK/p38‐K stimulation suggesting a signalling cascade from the gp39/CD40L via p56 lck and Rac1 to JNK/p38‐K.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(97)01306-9
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1997
ZDB Id:
1460391-3
SSG:
12
Bookmarklink