In:
EMBO reports, EMBO, Vol. 18, No. 8 ( 2017-08), p. 1382-1396
Abstract:
image Mammalian Atg8 proteins are separated into LC3 and GABARAP families that interact with autophagy receptors or adaptors via an LC3 interaction region (LIR). This study defines a GABARAP interaction motif (GIM) to aid our understanding of the individual families’ function. Identification of a G ABARAP I nteraction M otif (GIM; [W/F]‐[V/I] ‐x 2 ‐V). The LIR of the lysosomal adaptor protein PLEKHM1 conforms to the newly defined GIM and interacts with GABARAP in vivo . LIR specificity can be altered by single amino acid substitutions in the previously unassigned X 1 and X 2 residues in the classical W‐X 1 ‐X 2 ‐L motif. Mutation of known LIRs to a GIM, drives interaction with endogenous GABARAP over LC3.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201643587
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2025376-X
SSG:
12
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