In:
Annual Review of Genetics, Annual Reviews, Vol. 49, No. 1 ( 2015-11-23), p. 367-394
Abstract:
Over the past decade, bacterial small RNAs (sRNAs) have gone from a biological curiosity to being recognized as a major class of regulatory molecules. High-throughput methods for sampling the transcriptional output of bacterial cells demonstrate that sRNAs are universal features of bacterial transcriptomes, are plentiful, and appear to vary extensively over evolutionary time. With ever more bacteria coming under study, the question becomes how can we accelerate the discovery and functional characterization of sRNAs in diverse organisms. New technologies built on high-throughput sequencing are emerging that can rapidly provide global insight into the numbers and functions of sRNAs in bacteria of interest, providing information that can shape hypotheses and guide research. In this review, we describe recent developments in transcriptomics (RNA-seq) and functional genomics that we expect to help us develop an integrated, systems-level view of sRNA biology in bacteria.
Type of Medium:
Online Resource
ISSN:
0066-4197
,
1545-2948
DOI:
10.1146/genet.2015.49.issue-1
DOI:
10.1146/annurev-genet-112414-054804
Language:
English
Publisher:
Annual Reviews
Publication Date:
2015
detail.hit.zdb_id:
1470448-1
SSG:
12
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