In:
Natural Product Communications, SAGE Publications, Vol. 4, No. 7 ( 2009-07), p. 1934578X0900400-
Abstract:
Screening and chromatographic analysis of the extracts from the terrestrial streptomycete GW5127 and from the marine Streptomyces sp. isolate B7967 yielded four new metabolites, i.e. 8-ethyl-6,11-dihydroxy-1-methoxy-naphthacene-5,12-dione (1a), 4-acetyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one (4a), 5-hydroxmethyl-4-hydroxy-2,4-dimethyl-2-cyclopentenone (6), and N-[2-(3′-hydroxy-4′-methoxyphenyl)-ethyl] -acetamide (5a), along with five known compounds, β-rubromycin (2), γ-rubromycin (3), 2-(3′-hydroxy-4′-methoxyphenyl)ethanol (5b), uracil, and N-acetyltyramine. The structures of the new compounds were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. The antibiotic activity of the crude extracts was due to 2 and 3.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X0900400718
Language:
English
Publisher:
SAGE Publications
Publication Date:
2009
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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