In:
Green Processing and Synthesis, Walter de Gruyter GmbH, Vol. 3, No. 2 ( 2014-04-1), p. 111-116
Abstract:
According to literature, the synthesis of dronic acid derivatives from the corresponding carboxylic acids using phosphorus trichloride and phosphorous acid as the P -reactants is controversial, due to the wide range of molar ratios and diverse conditions. In this minireview, we summarize our results on the clarification of these problems. For example, with zoledronic acid and risedronic acid, we found that, using methanesulfonic acid (MSA) as the solvent, 3.2 equivalents of phosphorus trichloride was enough. Generalizing this optimized method, etidronate, fenidronate, ibandronate and alendronate were obtained in yields of 38%–57%, which is reasonable for valuable dronates, and in most cases, with high purities. Mechanistic aspects are also discussed.
Type of Medium:
Online Resource
ISSN:
2191-9550
,
2191-9542
DOI:
10.1515/gps-2013-0107
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2014
detail.hit.zdb_id:
2645923-1
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