UID:
edocfu_9958103988102883
Umfang:
1 online resource (321 p.)
ISBN:
3-318-00262-3
Serie:
Monographs in virology ; 21
Inhalt:
Cytomegalovirus (CMV) infection can cause severe diseases with significant morbidity and mortality in immunocompromised patients such as bone marrow or solid-organ transplant recipients, and AIDS patients. Major manifestations include transplant rejection, hepatitis, pneumonitis, encephalitis and retinitis. There is growing evidence that in certain cases CMV disease is closely linked to aberrant immune responses occurring locally within the respective tissues. This book provides important new insights into CMV-related immunopathology, discusses current methods of CMV diagnosis and anti-CMV therapy, and proposes novel antiviral treatment strategies. It contains contributions by leading scientists and clinicians in the field of CMV, who participated in the ‘First International Round Table Consensus Meeting’, held in Frankfurt, Germany, in August 1997. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working on herpesvirus biology and the development of antiviral drugs.
Anmerkung:
Description based upon print version of record.
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""Contents""; ""Preface""; ""Patronage of the Meeting""; ""Sponsors""; ""Acknowledgements""; ""Cytomegalovirus Persistence: Escape from Cell-Mediated Immunosurveillance""; ""Mechanisms of Immunosuppression by Human Cytomegalovirus""; ""Human Cytomegalovirus Infection in Transplant Recipients: Role of TNF-a for Reactivation and Replication of Human Cytomegalovirus""; ""Pathogenesis of Murine Cytomegalovirus Infection in Neonatal Mice""; ""Cytomegalovirus as a Perturbing Factor in Graft/Host Equilibrium: Havoc at the Endothelial Interface""
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""Current Antiviral Therapy Fails to Prevent the Pro-Inflammatory Effects of Cytomegalovirus Infection,Whilst Rendering Infected Cells Relatively Resistant to Immune Attack""""Cytomegalovirus, Oxidative Stress and Inflammation as Interdependent Pathomechanisms: Need for Novel Therapeutic Strategies?""; ""Cytomegalovirus Infection following Hematopoietic Stem Cell Transplantation""; ""Cytomegalovirus Pathogenesis after Experimental Bone Marrow Transplantation""
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""Two Types of Cytomegalovirus-Specific Memory Responses: Potential Role of Donor Infected Target Cells in Recruitment of Activated T Cells to the Graft1""""Role of Cytomegalovirus Infection in the Processes of Organ Allograft Rejection""; ""Role of Cytomegalovirus Infection in Transplant Arteriosclerosis""; ""CMV Retinitis: Clinical Experience with theMetal Chelator Desferrioxamine""; ""Drug Resistance and the UL97 Gene of Human Cytomegalovirus""; ""Antiviral Agents That Are Active against CMV: Potential of Cidofovir for the Treatment of CMV and Other Virus Infections""
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""Cidofovir, a New Addition to the Available Therapies against Cytomegalovirus""""New Anti-CMV Strategies""; ""Immunomodulation with Intravenous Immunoglobulins in the Treatment of Cytomegalovirus-Associated Immunopathology and Autoimmune Diseases""; ""Analytical Performance of a Quantitative CMV DNA DetectionMethod""; ""Relationship between Monitoring the Viral Load in Blood, Human Cytomegalovirus Pathophysiology and Management Strategies of Patients after Transplantation""; ""Quantitative Cytomegalovirus Detection""
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""Relative Importance of Cytomegalovirus Load as a Risk Factor for Cytomegalovirus Disease in the Immunocompromised Host""""Author Index""; ""Subject Index""
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English
Weitere Ausg.:
ISBN 3-8055-6602-6
Sprache:
Englisch
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