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  • SAGE Publications  (2)
  • 2005-2009  (2)
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  • SAGE Publications  (2)
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  • 2005-2009  (2)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2006
    In:  Journal of Histochemistry & Cytochemistry Vol. 54, No. 9 ( 2006-09), p. 1015-1020
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 54, No. 9 ( 2006-09), p. 1015-1020
    Abstract: Biological effects of substance P (SP) are mediated by the neurokinin-1 (NK 1 ) receptor that exists as a full-length and as a carboxy-terminally truncated isoform in humans. Although NK 1 receptor mRNA and binding sites have been detected in certain malignancies, little is known about the cellular and subcellular localization of NK 1 receptor protein in human neoplastic tissues. We developed and characterized a novel anti-peptide antibody to the carboxy-terminal region of the human full-length NK 1 receptor. Specificity of the anti-serum was demonstrated by (1) detection of a broad band migrating at molecular mass 70,000-90,000 Da in Western blots of membranes from NK 1 -expressing tissues; (2) cell-surface staining of NK 1 -transfected cells; (3) translocation of NK 1 receptor immunostaining after SP exposure; and (4) abolition of tissue immunostaining by preadsorption of the antibody with its immunizing peptide. Distribution of NK 1 receptors was investigated in 72 formalin-fixed, paraffin-embedded human tumors showing that NK 1 receptors were frequently expressed in glioblastomas and breast and pancreatic carcinomas. Immunoreactive NK 1 receptors were clearly confined to the plasma membrane and uniformly present on nearly all tumor cells. Development of this novel NK 1 receptor antibody allows the efficient localization of NK 1 receptor protein in human formalin-fixed, paraffin-embedded tissues. NK 1 receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention using SP analogs.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2008
    In:  Journal of Low Frequency Noise, Vibration and Active Control Vol. 27, No. 1 ( 2008-03), p. 65-74
    In: Journal of Low Frequency Noise, Vibration and Active Control, SAGE Publications, Vol. 27, No. 1 ( 2008-03), p. 65-74
    Abstract: Active vibration control (AVC) based on adaptive finite impulse response (FIR) filters inhere delays in conditional signal dispersion. Reasons for these delays are geometrical arrangements, and computational time in analog digital converters (ADCs) and in digital analog converters (DACs). The delays represent a phase shift in periodic signals. These delays avoid instant feedback of the signals through the least mean square (LMS) algorithm. This can lead to instability and even divergence. This study presents a modification of the LMS algorithm by adjusting the underlying gradient descent algorithm. Using analytic considerations, it shows the conditions of convergence for the stepsize as well as the gradient. The result is that all delays occurring can be compensated entirely. Unlike the delayed LMS algorithm, the introduced method considers possible delays analytically and furnishes the possibility for a perfect delay compensation. Modifications are easy to put into practice and were researched and verified using various simulations. Measurements on a duct in a range from 100 Hz to 1000 Hz confirm the success of adjustment and show an excellent convergence over the whole tested frequency range. Signal manipulation, for example, with a low-pass filter, which allows reverse phase shifts between – π and π, results only in a small frequency range and may be omitted by using the delay compensated LMS algorithm. The analytic mathematical derivation of the required modification can be implemented easily.
    Type of Medium: Online Resource
    ISSN: 1461-3484 , 2048-4046
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2025887-2
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