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  • Hindawi Limited  (1,285)
  • 2010-2014  (1,285)
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  • Hindawi Limited  (1,285)
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  • 2010-2014  (1,285)
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  • 1
    Online Resource
    Online Resource
    Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population
    Hindawi Limited ; 2012
    In:  Disease Markers Vol. 33, No. 6 ( 2012), p. 303-308
    Details
    In: Disease Markers, Hindawi Limited, Vol. 33, No. 6 ( 2012), p. 303-308
    Abstract: Background : Ageing is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. The study aims to find out the status of lipid profile, antioxidant enzymes, malondialdehyde in geriatric population. Patients/methods : The study was conducted on 150 subjects (75 healthy control between the ages of 20–30 years and 75 elderly subjects between ages of 50–70 years as cases). The following parameters were analyzed using the standard reference methods: lipid profile, reduced glutathione, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase and malondialdehyde. Results : The present study was conducted to estimate the oxidative stress parameters in geriatric population. Highly significant increase in total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), malondialdehyde, catalase and decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase was observed in geriatrics when compared with their younger counterparts. Conclusion : This study concluded that there is enhanced oxidative stress and decreased antioxidant defence in geriatrics as compared to younger subjects which could play an important role in ageing. Dyslipidemia has become one of the important risk factors for the increasing prevalence of cardiovascular diseases. There is lack of awareness on the relationship between blood lipids and the risk of cardiovascular diseases in geriatric population. The strategy of early prevention should be adopted against dyslipidemia.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2012/324696
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2033253-1
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  • 2
    Online Resource
    Online Resource
    Radiative Impact of Fireworks at a Tropical Indian Location: A Case Study
    Hindawi Limited ; 2014
    In:  Advances in Meteorology Vol. 2014 ( 2014), p. 1-8
    Details
    In: Advances in Meteorology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: During Diwali festival, extensive burning of crackers and fireworks is made. Weeklong intensive observational campaign for aerosol study was carried out at a representative urban location in the eastern Indo-Gangetic Plain (IGP), Varanasi (25.3°N, 83.0°E), from October 29 to November 04, 2005 (Diwali on November 01, 2005), to investigate behavioral change of aerosol properties and radiative forcing between firework affected and nonaffected periods. Results show a substantial increase (~27%) in aerosol optical depth, aerosol absorption coefficients, and aerosol scattering coefficients during affected period as compared to non-affected periods. Magnitudes of radiative forcing at top of atmosphere during affected and non-affected periods are found to be +10 ± 1 and +12 ± 1 Wm −2 , respectively, which are −31 ± 7 and −17 ± 5 Wm −2 , respectively, at surface. It suggests an additional cooling of ~20% at top of atmosphere, ~45% cooling at surface, and additional atmospheric heating of 0.23 Kday −1 during fireworks affected period, which is ~30% higher than the non-affected period average.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    URL: Article
    DOI: 10.1155/2014/197072
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2486777-9
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  • 3
    Online Resource
    Online Resource
    Canine Babesiosis in Northwestern India: Molecular Detection and Assessment of Risk Factors
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-5
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-5
    Abstract: In the current study, a total of 214 blood samples from dogs in and around Ludhiana, Punjab (India), suspected for canine babesiosis were examined with conventional and molecular assays. Examination of Giemsa-stained peripheral thin blood smears revealed an overall prevalence of 7.47% (16/214) for canine babesiosis encompassing 0.93% (2/214) of large Babesia and 6.54% (14/214) of Babesia gibsoni . However, molecular diagnosis revealed 15.42% (33/214) samples positive for B. gibsoni infection as evident by the presence of 671 bp amplicon. The results of multivariate analysis showed that the prevalence of B. gibsoni was associated with various risk factors, namely, age ( P 〈 0.001 ; OR: 0.398; CI 95%: 0.080–1.799), sex ( P = 0.022 ; OR: 0.849; CI 95%: 0.403–1.791), breed of host ( P = 0.371 ; OR: 3.345; CI 95%: 1.045–10.710), and season ( P = 0.230 ; OR: 2.143; CI 95%: 0.788–5.830). The prevalence of B. gibsoni was higher in summer as compared to winter season and in younger dogs, while breed and sex of the host were not significantly associated with the occurrence of the disease.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/741785
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 4
    Online Resource
    Online Resource
    Current Overview of Allergens of Plant Pathogenesis Related Protein Families
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-19
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-19
    Abstract: Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/543195
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
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  • 5
    Online Resource
    Online Resource
    Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
    Hindawi Limited ; 2014
    In:  Journal of Nutrition and Metabolism Vol. 2014 ( 2014), p. 1-5
    Details
    In: Journal of Nutrition and Metabolism, Hindawi Limited, Vol. 2014 ( 2014), p. 1-5
    Abstract: Background . HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipodystrophy. Study Design . One hundred and one HIV male patients were categorised into ART naïve ( n = 22 ), zidovudine ( n = 22 ), stavudine ( n = 18 ), tenofovir ( n = 15 ), and PIs ( n = 24 ) based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results . Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3%) and PIs (20 patients, 83.3%) based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%). The waist-hip ratio was significantly higher in PIs ( P = 0.01 ) based HAART. There was no significant difference among different study populations in terms of BMI ( P = 0.917 ), body water ( P = 0.318 ), body fat ( P = 0.172 ), bone mass ( P = 0.200 ), and muscle mass ( P = 0.070 ). Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL) was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion . Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face.
    Type of Medium: Online Resource
    ISSN: 2090-0724 , 2090-0732
    URL: Article
    DOI: 10.1155/2014/498497
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2573563-9
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  • 6
    Online Resource
    Online Resource
    Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
    Hindawi Limited ; 2010
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 7, No. 3 ( 2010), p. 317-322
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 7, No. 3 ( 2010), p. 317-322
    Abstract: The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg −1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro . The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus , which could help prevention of hyperlipidemia and related diseases.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1093/ecam/nen001
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients
    Hindawi Limited ; 2013
    In:  BioMed Research International Vol. 2013 ( 2013), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: The Toll-Like receptor 4 (TLR4) plays an important role in immunity, tissue repair, and regeneration. The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM). PCR-RFLP was used for genotyping TLR4 SNPs in 125 T2DM patients with DFU and 130 controls. The haplotypes and linkage disequilibrium between the SNPs were determined using Haploview software. Multivariate linear regression (MLR) and artificial neural network (ANN) modeling was done to observe their predictability for the risk of DFU in T2DM patients. Risk genotypes of all SNPs except rs1927914 were significantly associated with DFU. Haplotype ACATC ( P value = 9.3 E - 5 ) showed strong association with DFU risk. Two haplotypes ATATC ( P value = 0.0119) and ATGTT ( P value = 0.0087) were found to be protective against DFU. In conclusion TLR4 SNPs and their haplotypes may increase the risk of impairment of wound healing in T2DM patients. ANN model (83%) is found to be better than the MLR model (76%) and can be used as a tool for the DFU risk assessment in T2DM patients.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2013/318686
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2698540-8
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  • 8
    Online Resource
    Online Resource
    Status of Day Care Laparoscopic Appendectomy in Developing Countries
    Hindawi Limited ; 2014
    In:  International Scholarly Research Notices Vol. 2014 ( 2014-07-10), p. 1-5
    Details
    In: International Scholarly Research Notices, Hindawi Limited, Vol. 2014 ( 2014-07-10), p. 1-5
    Abstract: The practice of laparoscopic appendectomy as an ambulatory surgery is uncommon even in apex institutes, more so in developing countries, despite proven feasibility. To promote this practice in the developing countries like ours, we attempted to find the safety and cost effectiveness in such institutions which have limited resources. Thirty cases of symptomatic appendicitis were tried for same day discharge after laparoscopic appendectomies. The results were encouraging with 87% patients discharged on the same day and 13% on the next day in the early morning. Among the next day discharged cases, only 03% stayed for medical reasons (nausea, vomiting, and pain) while 10% stayed as their attendants declined to leave (social reasons), even though they were medically eligible for discharge from the hospital. There were no significant postoperative complications except tolerable pain in all patients and mild to moderate nausea/vomiting in 80%. There was no readmission. The mean length of hospital stay was 11.20 hrs. At the time of discharge all patients were highly satisfied. We concluded that routine same day discharge is safe and feasible after appendectomies in developing countries, with social decline as the main hurdle which can be improved by proper communication.
    Type of Medium: Online Resource
    ISSN: 2356-7872
    URL: Article
    DOI: 10.1155/2014/502786
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2778458-7
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  • 9
    Online Resource
    Online Resource
    Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats
    Hindawi Limited ; 2014
    In:  International Scholarly Research Notices Vol. 2014 ( 2014-10-29), p. 1-9
    Details
    In: International Scholarly Research Notices, Hindawi Limited, Vol. 2014 ( 2014-10-29), p. 1-9
    Abstract: The present study was carried out to evaluate the anticonvulsant activity and probable mechanism of action of the methanol root extract from I. frutescens (MEIF) using different experimental animal models. Anticonvulsant activity of the single dose of MEIF (100, 200, and 400 mg/kg, p.o.) was evaluated in maximal electroshock- (MES-), pentylenetetrazole- (PTZ-), and isoniazid- (INH-) induced convulsions models in rats. The levels of γ -amino butyric acid (GABA), glutamate, GABA-transaminase (GABA-T) activity and oxidative stress markers were measured in pretreated rat’s brain homogenate to corroborate the mechanism of observed anticonvulsant activity. MEIF (200–400 mg/kg, p.o.) protected the animals in all the behavioral models used. Pretreatment of MEIF (200–400 mg/kg, p.o.) and diazepam (1.0 mg/kg, i.p.) to the animals in INH-induced convulsion model showed 100% and 80% protection, respectively, as well as significant restoration of GABA and glutamate level in the rat’s brain. MEIF and vigabatrin (50 mg/kg, i.p.) reduced the PTZ-induced increase in the activity of GABA-T (46%) in the brain. Further, MEIF reversed the PTZ-induced increase in lipid peroxidase (LPO) and decrease in reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities. The findings of this study validate the anticonvulsant activity of I. frutescens .
    Type of Medium: Online Resource
    ISSN: 2356-7872
    URL: Article
    DOI: 10.1155/2014/434179
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2778458-7
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  • 10
    Online Resource
    Online Resource
    Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery
    Hindawi Limited ; 2012
    In:  ISRN Pharmaceutics Vol. 2012 ( 2012-07-19), p. 1-14
    Details
    In: ISRN Pharmaceutics, Hindawi Limited, Vol. 2012 ( 2012-07-19), p. 1-14
    Abstract: Lipid-based innovations have achieved new heights during the last few years as an essential component of drug development. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site. A number of novel drug delivery systems has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Microparticulate lipoidal vesicular system represents a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. Also, novel lipid carrier-mediated vesicular systems are originated. This paper has focused on the lipid-based supramolecular vesicular carriers that are used in various drug delivery and drug targeting systems.
    Type of Medium: Online Resource
    ISSN: 2090-6153
    URL: Article
    DOI: 10.5402/2012/474830
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2623569-9
    SSG: 15,3
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