In:
British Journal of Haematology, Wiley, Vol. 136, No. 6 ( 2007-03), p. 829-832
Abstract:
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T‐cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5‐aza‐2′‐deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour‐specific biomarker.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2007.136.issue-6
DOI:
10.1111/j.1365-2141.2007.06512.x
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1475751-5
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