X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SAGE Publications  (32)
  • Chen, Lei  (32)
Type of Medium
Publisher
  • SAGE Publications  (32)
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Association between blood pressure and different antihypertensive drugs with outcome after ischemic stroke: A Mendelian randomization study
    SAGE Publications ; 2023
    In:  International Journal of Stroke
    Details
    In: International Journal of Stroke, SAGE Publications
    Abstract: Observational studies suggest an association between blood pressure (BP) and functional outcomes in ischemic stroke patients but whether this is causal or due to confounding is uncertain. We used Mendelian randomization (MR) to assess causality, and also explore whether particular classes of anti-hypertensives were associated with a better outcome after ischemic stroke. Methods: We selected genetic variants associated with systolic and diastolic BP and BP-lowering variants in genes encoding antihypertensive drugs from genome-wide association studies (GWAS) on 757,601 individuals. The primary outcome was 3-month dependence or death defined as a modified Rankin Scale (mRS) of 3–6. The secondary outcome was disability or death after 90 days defined as mRS 2–6. Cochran’s Q statistic in the inverse variance weighted (IVW) model, the weighted median, MR-Egger regression, leave-one-single-nucleotide polymorphism (SNP)-out analysis, MR-Pleiotropy Residual Sum and Outlier methods were adopted as sensitivity analyses. To validate our primary results, we performed independent repeat analyses and Bi-directional MR analyses. Results: Genetic predisposition to higher systolic and diastolic BP was associated with disability or death after ischemic stroke in univariable IVW MR analysis (odds ratio (OR) 1.29, 95% confidence interval (CI): 1.05–1.59, p = 0.014; OR 1.27, 95% CI: 1.07–1.51, p = 0.006, respectively). Pulse pressure was associated with both dependence or death and disability or death after ischemic stroke (OR = 1.05, 95% CI: 1.02–1.08, p = 0.002; OR = 1.04, 95% CI = 1.01–1.07, p = 0.009, respectively). Angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) were significantly associated with improved functional outcomes (dependence or death, OR 0.76, 95% CI: 0.62–0.94, p = 0.009; OR 0.89, 95% CI: 0.83–0.97, p = 0.005). Proxies for β-blockers, angiotensin receptor blockers (ARB), and thiazides failed to show associations with functional outcomes ( p  〉  0.05). Conclusion: We provide evidence for an association of genetic predisposition to higher BP with a higher risk of 3-month functional dependence after ischemic stroke. Our findings support ACEI and CCB as promising antihypertensive drugs for improving functional outcomes in ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930231185695
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 2
    Online Resource
    Online Resource
    A novel carborane-containing ceramic precursor: Synthesis, characterization, and ceramic conversion mechanism
    SAGE Publications ; 2019
    In:  High Performance Polymers Vol. 31, No. 6 ( 2019-08), p. 694-706
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 31, No. 6 ( 2019-08), p. 694-706
    Abstract: Linear carborane-carbosilane-phenylacetylene polymers have been synthesized as precursors for ceramic and characterized by Fourier transform infrared (FT-IR), proton nuclear magnetic resonance ( 1 H-NMR), and carbon-nuclear magnetic resonance ( 13 C-NMR). Novel linear polymers have the advantage of being extremely easy to process and convert into ceramics, since they are either viscous liquids or low melting solids at room temperature and are soluble in most organic solvents. Ceramic conversion reaction of the polymers was studied, and the conversion mechanism using thermogravimetric analyzer, FT-IR, and pyrolysis-gas chromatography-mass spectrometry was proposed. During the early heating period in the mechanism, the precursor polymer is cured and oligomer is formed. Then the degradation of oligomer takes place at higher temperatures with the weak bond cleaved and cross-linked simultaneously. Ceramic yield of the polymer after heating up to 1000°C in nitrogen (N 2 ) was 77.6%. The derived ceramics exhibit excellent thermal and thermo-oxidative stability, whose 5% mass loss temperature was identified to be 650°C in N 2 and 665°C in air, respectively. Boron appears to be the key element to achieve the outstanding thermo-oxidative stability. The relevant kinetic data were obtained by two kinds of model-free-kinetic algorithms, differential Friedman and integral Kissinger–Akahira–Sunose. These two methods were combined to give the energy profile, which has been identified to be a function of the transformation degree ( α), since the energy demand at each degradation stage is different depending on α.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008318788389
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1483713-4
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 3
    Online Resource
    Online Resource
    Comparison of clinical and serological features of RT-PCR positive and negative COVID-19 patients
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 2 ( 2021-02), p. 030006052097265-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 2 ( 2021-02), p. 030006052097265-
    Abstract: In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan, China, and led to a global epidemic. We aimed to compare the clinical and serological features of COVID-19 patients with positive and negative reverse transcriptase polymerase chain reaction (RT-PCR) tests. Methods This was a retrospective cohort study conducted from 9 February to 4 April 2020. COVID-19 patients at Leishenshan Hospital in Wuhan, China (125 total cases; 87 RT-PCR positive and 38 RT-PCR negative) were included. COVID-19 serology was assessed by colloidal gold assay. All cases were analyzed for demographic, clinical, and serological features. Results There were no significant differences in most demographic features, clinical symptoms, complications or treatments of RT-PCR positive and negative COVID-19 patients. Serum IgM/IgG was positive in 82 (94%) and 33 (87%) RT-PCR positive and negative cases, respectively. IgM was detectable as early as 3 days after symptom onset and was undetectable 60 days after symptom onset. By contrast, IgG could be detected only 10 days after symptom onset and reached its peak 60 days after symptom onset. Conclusions Serological tests performed during the appropriate time window of disease progression could be valuable auxiliary methods to RT-PCR in COVID-19 patients.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520972658
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 4
    Online Resource
    Online Resource
    The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation
    SAGE Publications ; 2022
    In:  Journal of International Medical Research Vol. 50, No. 7 ( 2022-07), p. 030006052211093-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 50, No. 7 ( 2022-07), p. 030006052211093-
    Abstract: To explore the influence of apolipoprotein E ( APOE) genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF). Methods Patients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid levels and APOE genotypes were determined and analysed for associations with CAD and AF. Results A total of 2048 patients were included (400 patients without CAD or AF [controls], 126 patients without CAD but with AF, 1294 patients with CAD without AF, and 228 patients with CAD and AF). Age and lipoprotein (a) (Lp[a] ) levels were significantly higher in patients with CAD and AF versus those with CAD without AF. Among patients with CAD, the E3/E3 genotype and ε3 allele frequencies were significantly lower in patients with AF than in those without AF, and the E4/E4 genotype and ε4 allele frequencies were significantly increased. Multivariate logistic regression revealed that increased Lp(a) levels and age were independent risk factors for AF in patients with CAD. Conclusion Among patients with CAD, those with AF had increased age, ε4 frequencies and Lp(a) levels. Age and Lp(a) levels may be independent risk factors for AF in patients with CAD.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605221109387
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2082422-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 5
    Online Resource
    Online Resource
    The building plan automatic design optimization based on CFD numerical intelligent simulation
    SAGE Publications ; 2023
    In:  Indoor and Built Environment Vol. 32, No. 4 ( 2023-04), p. 734-749
    Details
    In: Indoor and Built Environment, SAGE Publications, Vol. 32, No. 4 ( 2023-04), p. 734-749
    Abstract: To apply the thermal comfort to the optimization of building layout, a variable design method based on K means clustering is proposed. The evaluation was based on numerical simulation, genetic algorithm and universal thermal climate index (UTCI) to implement the building layout optimization on Matlab. Finally, the building layouts with centralized type, decentralized type and edge flow type water configuration were optimized, respectively. The results show that after the optimization, a reduction of 0.1∼0.6°C of UTCI was observed. We concluded that under moderate heat stress, the increase in wind velocity is the key to thermal comfort improvement.
    Type of Medium: Online Resource
    ISSN: 1420-326X , 1423-0070
    URL: Article
    DOI: 10.1177/1420326X221134981
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1482713-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 6
    Online Resource
    Online Resource
    Combining Ketamine with Astrocytic Inhibitor as a Potential Analgesic Strategy for Neuropathic Pain. Ketamine, Astrocytic Inhibitor and Pain
    SAGE Publications ; 2010
    In:  Molecular Pain Vol. 6 ( 2010-01-01), p. 1744-8069-6-50-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 6 ( 2010-01-01), p. 1744-8069-6-50-
    Abstract: Neuropathic pain is an intractable clinical problem. Intrathecal ketamine, a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to be useful for treating neuropathic pain in clinic by inhibiting the activity of spinal neurons. Nevertheless, emerging studies have disclosed that spinal astrocytes played a critical role in the initiation and maintenance of neuropathic pain. However, the present clinical therapeutics is still just concerning about neuronal participation. Therefore, the present study is to validate the coadministration effects of a neuronal noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and astrocytic cytotoxin L-α-aminoadipate (LAA) on spinal nerve ligation (SNL)-induced neuropathic pain. Results: Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated SNL-induced mechanical allodynia in a dose-dependent manner respectively. Phosphorylated NR1 (pNR1) or glial fibrillary acidic protein (GFAP) expression was down-regulated by intrathecal ketamine (100, 1000 μg/kg) or LAA (50, 100 nmol) respectively. The combination of ketamine (100 μg/kg) with LAA (50 nmol) showed superadditive effects on neuropathic pain compared with that of intrathecal administration of either ketamine or LAA alone. Combined administration obviously relieved mechanical allodynia in a quick and stable manner. Moreover, down-regulation of pNR1 and GFAP expression were also enhanced by drugs coadministration. Conclusions: These results suggest that combining NMDAR antagonist ketamine with an astrocytic inhibitor or cytotoxin, which is suitable for clinical use once synthesized, might be a potential strategy for clinical management of neuropathic pain.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-6-50
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2174252-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 7
    Online Resource
    Online Resource
    A phase III, randomized, double-blind, controlled trial of carboxyamidotriazole plus chemotherapy for the treatment of advanced non-small cell lung cancer
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592096584-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592096584-
    Abstract: Carboxyamidotriazole (CAI), a calcium channel blocker, inhibits tumor cell proliferation, metastasis, and angiogenesis. This trial aimed to determine whether CAI combined with conventional chemotherapy could prolong progression-free survival (PFS) in non-small cell lung cancer (NSCLC) patients. Methods: Patients were assigned into groups (3:1 ratio) to receive either chemotherapy + CAI or chemotherapy alone. Cisplatin (25 mg/m 2 ) was administered by intravenous infusion on days 1, 2, and 3, and vinorelbine (25 mg/m 2 ) on days 1 and 8 of each 3-week cycle for four cycles. CAI was administered at 100 mg daily with concomitant chemotherapy; this treatment was continued after chemotherapy was ceased until serious toxicity or disease progression had occurred. PFS was the primary endpoint, and the secondary endpoints were objective response rate (ORR), disease control rate, overall survival (OS), and quality of life. Results: In total, 495 patients were enrolled in the trial: 378 in the chemotherapy + CAI group and 117 in the chemotherapy + placebo group. PFS was significantly greater in the chemotherapy + CAI [median, 134 days; 95% confidence interval (CI) 127–139] than in the chemotherapy + placebo (median, 98 days; 95% CI: 88–125) group, with a hazard ratio of 0.690 (95% CI: 0.539–0.883; p = 0.003). There was no difference in the OS rates of both groups. The ORR was greater in the chemotherapy + CAI group than in the chemotherapy + placebo group (34.6% versus 25.0%, p = 0.042). Adverse events of ⩾grade 3 occurred more frequently in the CAI group [256 (68.1%) versus 64 (55.2%); p = 0.014] . Conclusion: CAI + platinum-based chemotherapy prolonged PFS and could be a useful therapeutic option to treat NSCLC. Clinical Trial Registration: chinadrugtrials.org.cn identifier: CTR20160395
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920965849
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 8
    Online Resource
    Online Resource
    The relationship between the internal condition and the ventilation environment in a modular building
    SAGE Publications ; 2021
    In:  Indoor and Built Environment Vol. 30, No. 3 ( 2021-03), p. 375-390
    Details
    In: Indoor and Built Environment, SAGE Publications, Vol. 30, No. 3 ( 2021-03), p. 375-390
    Abstract: This study explores the interaction between the indoor ventilation environment of a modular building and internal building elements, including relative position of modules, number and location of windows and standardized bathroom modules. The computer hydrodynamics technology was used for this research. The model was divided into three parts to simulate the ventilation environment: (i) the relative position of the module, (ii) the number and position of windows, and (iii) the position of the standardized bathroom module. The results of the simulation illustrate the need to balance the balcony space for indoor ventilation, which should be considered comprehensively during the actual design. From the perspective of the whole living unit, the ventilation condition is more advantageous when the four openings are along the external wind direction. In addition, it can improve efficiently the overall ventilation quality in the low wind speed zone by taking full advantage of the bathroom location in modular interior. In the process of a modular unit design, the relationship between standardized modules, window location, number and indoor comfort should be fully considered. With the simulation results, a relatively optimized standard of modular interior organization was established. In future, these variables can be adjusted according to actual needs.
    Type of Medium: Online Resource
    ISSN: 1420-326X , 1423-0070
    URL: Article
    DOI: 10.1177/1420326X19893044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 1482713-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 9
    Online Resource
    Online Resource
    Structure Activity Relationships of Flavonoids as Potent α-Amylase Inhibitors
    SAGE Publications ; 2014
    In:  Natural Product Communications Vol. 9, No. 8 ( 2014-08), p. 1934578X1400900-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 9, No. 8 ( 2014-08), p. 1934578X1400900-
    Abstract: The effects of three flavonoids (quercetin, luteolin, diosmetin) on α-amylase were examined by enzymatic kinetics and fluorescence spectroscopy. The three test flavonoids were non-competitive inhibitors of the enzyme. Addition of flavonoids led to fluorescence quenching of α-amylase. The quenching was initiated from the formation of a complex between the flavonoids and the enzyme, corresponding to a static quenching process. An α-amylase molecule provides a binding site for the test flavonoid. The main binding force was hydrophobic. The decreasing order of inhibition of α-amylase by flavonoids and the binding force was luteolin, diosmetin, and quercetin. It is demonstrated that hydroxylation in ring C and methylation of the hydroxyl group in ring B of flavonoids may weaken the binding affinities to α-amylase.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1400900829
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 10
    Online Resource
    Online Resource
    Study of Diffusion Performance and Preparation Technology of the Coloured PMIA Fibre
    SAGE Publications ; 2012
    In:  Polymers and Polymer Composites Vol. 20, No. 7 ( 2012-09), p. 601-608
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 20, No. 7 ( 2012-09), p. 601-608
    Abstract: Poly(m-phenylene isophthalamide) (PMIA) fibre is a kind of aromatic polyamide fibre, which can be prepared by a wet-spinning method. In this work, the process conditions of spinning influenced the performance and structure of the coloured PMIA fibre, and these conditions included spinning speed, coagulation bath, etc. Because the diffusion coefficient was associated with the performance and structure, the ratio of solvent to coagulant could explain the reason of influence of the coagulation bath on the fibre. In this study, PMIA spinning dopes with Colour Inde Blue 60 were first commixed in a pressurizer and then spun into a coagulation bath under a pressure of around 0.3 MPa. At a coagulation bath temperature of 50 °C, pure or dope-dyed PMIA fibres were prepared by wet spinning, and then the spun fibres were extracted by an ultrasonic oscillation method. The effect of the jet stretch ratio and the temperature and concentration of coagulation bath on the ratio of diffusion coefficient of solvent to coagulator were analysed during spinning process of dope-dyed PMIA fibres. The properties and structures of coloured PMIA fibres were characterized by SEM. Finally the optimized spinning technology of the dope-dyed PMIA fibre was obtained.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739111202000704
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2099644-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages