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  • Artikel  (10)
  • HU Berlin  (10)
  • Wissenschaftspark Albert Einstein
  • SB Wittenberge
  • 2005-2009  (10)
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  • 1
    Artikel
    Artikel
    HbA1c measurements from dried blood spots: validation and patient satisfaction (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_10583
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: This study evaluates HbA1c measurements from dried blood spots collected on filter paper and compares HbA1c from filter paper (capillary blood) with HbA1c measured in venous blood. Methods: Patient satisfaction was evaluated using a questionnaire. The performance with the filter paper method was assessed by comparing HbA1c results from EDTA-blood samples obtained via dried blood spots with HbA1c results obtained with freshly hemolyzed blood (routine HbA1c). Adult patients visiting the outpatient clinic for HbA1c analyses were recruited for the evaluation of dried blood spot sampling at home. Laboratory personnel collected a capillary blood sample on filter paper as well as a venous EDTA-blood sample. The participants collected another capillary blood sample at home and sent the dried filter paper back to the laboratory. Samples were analyzed with an immunoturbidimetric assay. Results: Between-filter coefficient of variation was 1.8%. Filter paper HbA1c increased slightly during storage, particularly during the first 5 days. Filter paper HbA1c highly correlated with routine HbA1c (r=0.987). The evaluation of samples collected at home showed comparable HbA1c values by filter paper and routine sampling methods (n=93). Eighty-three percent of participants said they would like the filter method to be brought into practice. Conclusions: Home HbA1c sampling on filter paper is an acceptable sampling alternative for analysis of HbA1c. Clin Chem Lab Med 2009;47:1259–64.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,10, Seiten 1259-1264, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2009.274
    DOI: 10.18452/9931
    URN: urn:nbn:de:kobv:11-100119691
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  • 2
    Artikel
    Artikel
    Quantitation of cerebrospinal fluid lactic acid in infectious and non-infectious neurological diseases (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_12767
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: The differential diagnosis between bacterial and viral meningitis is not easy in some cases. Cerebrospinal fluid (CSF) analysis is essential for establishing this diagnosis. The objectives were to quantitate lactic acid (LA) concentrations in bacterial and viral meningitis, and other central nervous system (CNS) diseases in order to evaluate the diagnostic utility of CSF LA for discriminating bacterial from viral meningitis. Methods: CSF LA was measured in 139 CSF samples from seven groups: viral meningitis with classic CSF; suspicion of viral meningitis with neutrophils in CSF; bacterial meningitis; non-infectious neurological diseases; chronic meningitis; traumatic lumbar puncture (LP) and normal CSF. Results: CSF LA was higher in bacterial meningitis 8.7+5.4 mmol/L compared with viral meningitis (1.9+0.6) and the other groups (p<0.0001). CSF LA in the groups with viral meningitis was not different compared to groups with non-infectious CNS diseases and chronic meningitis. The ability of CSF LA to discriminate bacterial from viral meningitis showed a sensitivity of 80% and specificity of 97%, positive predictive value (PPV) of 94%, and negative predictive value (NPV) of 89%. Conclusions: CSF LA is a powerful test to discriminate bacterial from viral meningitis with high sensitivity, specificity and predictive values. CSF LA can help in the cases with diagnostic uncertainty. Clin Chem Lab Med 2009;47:755–61.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,6, Seiten 755-761, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2009.160
    DOI: 10.18452/12115
    URN: urn:nbn:de:kobv:11-100153666
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  • 3
    Artikel
    Artikel
    „Alle Protestanten sind zu betrachten als zukünftige Katholiken”. Schlegels Konversionen (2008)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_6565
    In: Athenäum 18, 2008,2008,18
    Sprache: Deutsch
    DOI: 10.18452/5913
    URN: urn:nbn:de:kobv:11-0262-3953
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  • 4
    Artikel
    Artikel
    Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_12783
    ISSN: 1619-3997 , 1619-3997
    Inhalt: Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia.
    Inhalt: Peer Reviewed
    In: Journal of Perinatal Medicine, : de Gruyter, 2009, 37,2009,4, Seiten 343-348, 1619-3997
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/JPM.2009.060
    DOI: 10.18452/12131
    URN: urn:nbn:de:kobv:11-100153869
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  • 5
    Artikel
    Artikel
    A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_11421
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: It has been shown that low concentrations of high-density lipoprotein cholesterol (HDL-C) are associated with non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). HDL2b, a major subfraction of high-density lipoprotein (HDL), is more significantly correlated with coronary heart disease (CHD) compared with total HDL. In this study, we analysed HDL2b in a cohort of Chinese T2DM subjects with or without NAFLD. Methods: A highly sensitive and reliable microfluidic chip method was adopted to measure HDL2b. In total, 48 T2DM patients with NAFLD diagnosed by a B-ultrasound were enrolled from our Beijing Community Pre-Diabetes (BCPD) study cohort. A total of 48 age and gender matched diabetic controls without NAFLD were selected from the same population. Results: Clinical characteristics and serum biochemical analyses demonstrated a significantly increased body mass index (BMI), waist circumference, homeostasis model assessment-insulin resistant index (HOMA-IR), total cholesterol (TC), and triglyceride (TG) concentrations in the NAFLD group. However, the concentrations of HDL2b and its ratio to total HDL in NAFLD patients was decreased, compared with controls (p<0.01). Significantly increased concentrations of high sensitive C-reactive protein (hs-CRP) (p<0.01) were also found. Multifactor logistic regression analysis showed that BMI and TG were the predominant risk factors for fatty liver, while HDL2b was a protective factor. Conclusions: T2DM patients with NAFLD have characteristics including obesity, marked insulin resistance, high TG, high hs-CRP, low HDL2b and a low HDL2b ratio to total HDL. These factors may increase the incidence of atherosclerosis as well as the risk of CHD. Clin Chem Lab Med 2009;47:1067–72.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,9, Seiten 1067-1072, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2009.257
    DOI: 10.18452/10769
    URN: urn:nbn:de:kobv:11-100132312
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  • 6
    Artikel
    Artikel
    Intrathecal synthesis of tumor markers is a highly sensitive test in the diagnosis of leptomeningeal metastasis from solid cancers (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_13115
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: Identification of neoplastic cells in cerebrospinal fluid (CSF) by cytological analysis is the key diagnostic feature of leptomeningeal metastasis (LM). Because of the lack of sensitivity of this test, considerable efforts have been made to identify alternative diagnostic markers. Data from the literature suggest that measurement of tumor markers (TM) in CSF may be helpful for improving the diagnosis. Methods: We analyzed the concentrations of the TM carcinoembryonic antigen (CEA), CA15.3, CA125 and CA19.9 in both CSF and serum from 18 patients with neoplastic meningitis diagnosed by CSF cytology. We also performed these same measurements in 50 patients affected by other neurological diseases (OND) in order to evaluate putative intrathecal synthesis. In addition, CSF and serum concentrations of the proangiogenic factor VEGF (vascular endothelial growth factor) were evaluated. Results: All LM patients showed intrathecal synthesis for at least one TM. In one patient, a negative CSF cytology after treatment paralleled normalization of tumor marker synthesis. None of the OND patients displayed intrathecal TM synthesis. The VEGF Index (CSF/serum VEGF relative to CSF/serum albumin ratios) was significantly higher in LM patients compared with the control group. However, significant overlap between LM patients and values seen in those with OND was observed. Conclusions: Evaluation of intrathecal TM synthesis is a specific, sensitive, reliable, and reproducible diagnostic tool, and is useful to support diagnosis of carcinomatous meningitis. Clin Chem Lab Med 2009;47:874–9.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,7, Seiten 874-879, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2009.183
    DOI: 10.18452/12463
    URN: urn:nbn:de:kobv:11-100159114
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  • 7
    Artikel
    Artikel
    Parental mental representations during late pregnancy and early parenthood following assisted reproductive technology (2008)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_12785
    ISSN: 1619-3997 , 1619-3997
    Inhalt: Objective: To evaluate the relationship between assisted reproduction technology (ART) and parental mental representations during late pregnancy and early parenthood. Study design: Women (n=25) following ART pregnancies were compared with their partners (n=23) and with women following spontaneous conceptions (n=39). Subjects were interviewed on mental representations at late gestation and three months postpartum. Results: Socio-demographic and obstetrical characteristics were similar between groups. ART women tend to decrease scores of intensity of investment from before to after delivery. During pregnancy and postpartum, ambivalent representations were more often present and well-integrated representations were less often present among ART women as compared with non-ART women. ART women had significantly more ambivalent representations that persisted at three months postpartum, and men had more disengaged representations. Conclusions: A greater desire for pregnancy exists in ART women which might not always coincide with a desire for maternity. ART men, however, manifest greater disengagement from the entire child project.
    Inhalt: Peer Reviewed
    In: Journal of Perinatal Medicine, : de Gruyter, 2009, 37,2008,4, Seiten 320-327, 1619-3997
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/JPM.2009.062
    DOI: 10.18452/12133
    URN: urn:nbn:de:kobv:11-100153881
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  • 8
    Artikel
    Artikel
    Unstimulated high sensitive thyroglobulin measurement predicts outcome of differentiated thyroid carcinoma (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_13598
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: Thyroglobulin (Tg) measurement following thyrotropin (TSH) stimulation is used in the follow-up of patients with differentiated thyroid carcinoma (DTC). However, high-sensitive assays allow accurate measurement of serum Tg even without TSH stimulation. Here, we prospectively evaluated the impact of unstimulated high-sensitive Tg measurement in early and long-term outcome of patients with DTC. Methods: One hundred and ninety five patients affected with DTC were evaluated. Six months after thyroid ablation (i.e., thyroidectomy plus radioiodine) serum Tg was measured during TSH-suppressive thyroxine (T4) treatment (onT4-Tg). Patients with undetectable onT4-Tg and negative neck ultrasound (US) were considered disease free and onT4-Tg was measured every 12 months for a mean follow-up of 6.8 (4.7–8.9) years. Patients with an increase in onT4-Tg underwent specific diagnostic work-up and appropriate treatment if necessary. Results: Four patients showed recurrence at first follow-up visit with a corresponding increase in onT4-Tg concentrations (sensitivity 100%). Three patients had false positive onT4-Tg measurement (specificity 98%) with a spontaneous decrease within 3–6 months in all cases (specificity 100%). Three of 188 patients with undetectable serum onT4-Tg at first follow-up showed recurrence later with an increase in onT4-Tg as the first (n=2) or unique (n=1) sign of relapse (sensitivity 100%). Among 185 disease-free patients in a prolonged follow-up, 12 had a transient increase in onT4-Tg (specificity 91.6%). However, a spontaneous reduction within 3–6 months occurred in all cases (specificity 100%). Conclusions: Undetectable serum onT4-Tg using a high-sensitivity immunoradiometric assay 6 months after thyroid ablation predicts low-risk of DTC recurrence. When onT4-Tg became detectable during follow-up, the evaluation of Tg slope in a 3–6 months period accurately discriminated patients with DTC recurrence from those without recurrence. This helped avoid unnecessary diagnostic or therapeutic procedures. Clin Chem Lab Med 2009;47:1001–4.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 47,2009,8, Seiten 1001-1004, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2009.216
    DOI: 10.18452/12946
    URN: urn:nbn:de:kobv:11-100165712
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  • 9
    Artikel
    Artikel
    Dipeptidyl peptidases and related proteins : multifaceted markers and therapeutic targets (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_10095
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Peer Reviewed
    In: Clinical chemistry and laboratory medicine, , 2009, 47,2009,3, Seiten 245-247, 1437-4331
    Sprache: Englisch
    DOI: 10.1515/CCLM.2009.085
    DOI: 10.18452/9443
    URN: urn:nbn:de:kobv:11-10098701
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  • 10
    Artikel
    Artikel
    Determination of serum holotranscobalamin concentrations with the AxSYM active B12 assay: cut-off point evaluation in the clinical laboratory (2009)
    Berlin : Kooperation de Gruyter
    Details
    UID:
    edochu_18452_10244
    ISSN: 1437-4331 , 1437-4331
    Inhalt: Background: A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay. Methods: Determination of the cut-off threshold and correlation between HoloTC and the other diagnostic parameters routinely used for vitamin B12 deficiency [total vitamin B12 (tB12), folate, homocysteine] were measured in 250 routine blood specimens from 107 men (mean age 59.0±18.8 years) and 143 women (mean age 54.2±23.1 years). The inclusion criterion was serum tB12 concentration ≤221 pmol/L. Results: Analytical performance results agreed with those reported by others. A weak correlation (R=0.42) was found between HoloTC and tB12. A 40 pmol/L cut-off threshold was chosen for HoloTC and the associated sensitivity and specificity was 0.86 and 0.66, respectively. Out of 250 tested samples, 126 showed tB12 concentrations 139–221 pmol/L (gray zone, GZ) and 124 had tB12 concentrations <139 pmol/L (low, L). Values less than the cut-off for HoloTC were present in 68.2% and 37.9% of cases in the GZ and L group, respectively (p<0.01), and in 53.2% of subjects. Conclusions: Our results confirmed the analytical reliability of the AxSYM HoloTC assay. The method is adequate for routine use and a cut-off threshold of 40 pmol/L is appropriate for assessing cobalamin deficiency in populations with reduced tB12 values. Clin Chem Lab Med 2010;48:249–53.
    Inhalt: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2010, 48,2009,2, Seiten 249-253, 1437-4331
    Sprache: Unbestimmte Sprache
    DOI: 10.1515/CCLM.2010.032
    DOI: 10.18452/9592
    URN: urn:nbn:de:kobv:11-100114444
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