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  • 1
    Online Resource
    Online Resource
    Effects of Disruption of Structure and Motion on Perceptions of Social Causality
    SAGE Publications ; 1992
    In:  Personality and Social Psychology Bulletin Vol. 18, No. 2 ( 1992-04), p. 237-244
    Details
    In: Personality and Social Psychology Bulletin, SAGE Publications, Vol. 18, No. 2 ( 1992-04), p. 237-244
    Abstract: Subjects viewed and wrote free response descriptions of one of four short video displays. These displays consisted of either the classic Heider and Simmel animated film or one of three versions of the film that had been altered with a digital special effects generator In these altered versions, either (a) dynamic aspects of the original film were disrupted but structural properties preserved, (b) structural aspects of the film were disrupted but dynamic properties preserve or (c) both structural and dynamic properties of the film were disrupted. Analyses of subjects' descriptions provided evidence that perceivers' strong inclinations to describe the original display in anthropomorphic terms are largely based on the patterns of motion that characterize the film.
    Type of Medium: Online Resource
    ISSN: 0146-1672 , 1552-7433
    URL: Article
    DOI: 10.1177/0146167292182016
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1992
    detail.hit.zdb_id: 2047603-6
    SSG: 5,2
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  • 2
    Online Resource
    Online Resource
    Implementation of Care Management: An Analysis of Recent AHRQ Research
    SAGE Publications ; 2018
    In:  Medical Care Research and Review Vol. 75, No. 1 ( 2018-02), p. 46-65
    Details
    In: Medical Care Research and Review, SAGE Publications, Vol. 75, No. 1 ( 2018-02), p. 46-65
    Abstract: Care management (CM) is a promising team-based, patient-centered approach “designed to assist patients and their support systems in managing medical conditions more effectively.” As little is known about its implementation, this article describes CM implementation and associated lessons from 12 Agency for Healthcare Research and Quality–sponsored projects. Two rounds of data collection resulted in project-specific narratives that were analyzed using an iterative approach analogous to framework analysis. Informants also participated as coauthors. Variation emerged across practices and over time regarding CM services provided, personnel delivering these services, target populations, and setting(s). Successful implementation was characterized by resource availability (both monetary and nonmonetary), identifying as well as training employees with the right technical expertise and interpersonal skills, and embedding CM within practices. Our findings facilitate future context-specific implementation of CM within medical homes. They also inform the development of medical home recognition programs that anticipate and allow for contextual variation.
    Type of Medium: Online Resource
    ISSN: 1077-5587 , 1552-6801
    URL: Article
    DOI: 10.1177/1077558716673459
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2070248-6
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  • 3
    Online Resource
    Online Resource
    Bayesian clinical trials at the University of Texas M. D. Anderson Cancer Center
    SAGE Publications ; 2009
    In:  Clinical Trials Vol. 6, No. 3 ( 2009-06), p. 205-216
    Details
    In: Clinical Trials, SAGE Publications, Vol. 6, No. 3 ( 2009-06), p. 205-216
    Abstract: Background The Bayesian approach is being used increasingly in medical research. In particular, it has become a standard in designing clinical trials at the University of Texas M. D. Anderson Cancer Center. Purpose/Methods To address the extent and nature of Bayesian trials conducted at M. D. Anderson, we reviewed the protocols registered in the Protocol Document Online System between 2000 and early 2005. We summarize our findings and give details for three innovative trials that typify those in which a Bayesian approach has played a major role at the center. Results Of 964 protocols reviewed, 59% were conducted solely at M. D. Anderson and the rest were multicenter trials. Bayesian designs and analyses were used in about 20% (195/964) of the protocols that we reviewed. Of the 520 protocols identified as phase I or II drug trials, about 34% were Bayesian. Most of the 195 Bayesian trials were designed by M. D. Anderson statisticians. The Bayesian design features most commonly used were the continuous reassessment method in phase I (toxicity) trials, adaptive randomization in phase II trials, and designs to monitor efficacy and toxicity simultaneously. We also provide an insider's view regarding some practical considerations that have made the design and implementation of so many Bayesian trials possible. Limitations We reviewed only a subset of all M. D. Anderson protocols, but did not exclude any available in electronic form. Conclusions The large number of Bayesian trials conducted at M. D. Anderson testifies to the receptivity to the Bayesian approach within the center, including principal investigators, regulatory review committees, and patients. Statisticians who take a Bayesian perspective can successfully work to establish a culture of innovation in clinical trial design.
    Type of Medium: Online Resource
    ISSN: 1740-7745 , 1740-7753
    URL: Article
    DOI: 10.1177/1740774509104992
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2159773-X
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  • 4
    Online Resource
    Online Resource
    Methodological Approaches to the Study of Social Event Perception
    SAGE Publications ; 1994
    In:  Personality and Social Psychology Bulletin Vol. 20, No. 2 ( 1994-04), p. 139-152
    Details
    In: Personality and Social Psychology Bulletin, SAGE Publications, Vol. 20, No. 2 ( 1994-04), p. 139-152
    Abstract: The ecological-event-perception view of social knowing differs from the traditional cognitive approach to person perception in some fundamental ways. First, the ecological view holds that veridical information about people and their interactions is available in dynamic, ongoing stimulus events. Second, perception itself is conceptualized as a dynamic process, in which an active perceiver comes to recognize the potential of the environment through exploration and behavior These tenets provide researchers with some unique methodological challenges both when selecting stimuli for study and when assessing subjects' responses to those stimuli. This article describes a number of methodological approaches taken by researchers to deal with these problems. The advantages and disadvantages of each are discussed.
    Type of Medium: Online Resource
    ISSN: 0146-1672 , 1552-7433
    URL: Article
    DOI: 10.1177/0146167294202001
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2047603-6
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Generation of Reactive Oxygen Species from Silicon Nanowires
    SAGE Publications ; 2014
    In:  Environmental Health Insights Vol. 8s1 ( 2014-01), p. EHI.S15261-
    Details
    In: Environmental Health Insights, SAGE Publications, Vol. 8s1 ( 2014-01), p. EHI.S15261-
    Abstract: Processing and synthesis of purified nanomaterials of diverse composition, size, and properties is an evolving process. Studies have demonstrated that some nanomaterials have potential toxic effects and have led to toxicity research focusing on nanotoxicology. About two million workers will be employed in the field of nanotechnology over the next 10 years. The unknown effects of nanomaterials create a need for research and development of techniques to identify possible toxicity. Through a cooperative effort between National Institute for Occupational Safety and Health and IBM to address possible occupational exposures, silicon-based nanowires (SiNWs) were obtained for our study. These SiNWs are anisotropic filamentary crystals of silicon, synthesized by the vapor-liquid-solid method and used in bio-sensors, gas sensors, and field effect transistors. Reactive oxygen species (ROS) can be generated when organisms are exposed to a material causing cellular responses, such as lipid peroxidation, H 2 O 2 production, and DNA damage. SiNWs were assessed using three different in vitro environments (H 2 O 2 , RAW 264.7 cells, and rat alveolar macrophages) for ROS generation and possible toxicity identification. We used electron spin resonance, analysis of lipid peroxidation, measurement of H 2 O 2 production, and the comet assay to assess generation of ROS from SiNW and define possible mechanisms. Our results demonstrate that SiNWs do not appear to be significant generators of free radicals.
    Type of Medium: Online Resource
    ISSN: 1178-6302 , 1178-6302
    URL: Article
    DOI: 10.4137/EHI.S15261
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2452946-1
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  • 6
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    Online Resource
    Respiratory Toxicologic Pathology of Inhaled Diacetyl in Sprague-Dawley Rats
    SAGE Publications ; 2008
    In:  Toxicologic Pathology Vol. 36, No. 2 ( 2008-02), p. 330-344
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 36, No. 2 ( 2008-02), p. 330-344
    Abstract: Inhalation of butter flavoring vapors by food manufacturing workers causes an emerging lung disease clinically resembling bronchiolitis obliterans. Diacetyl, an α-diketone, is a major component of these vapors. In rats, we investigated the toxicity of inhaled diacetyl at concentrations of up to 365 ppm (time weighted average), either as six-hour continuous exposures or as four brief, intense exposures over six hours. A separate group inhaled a single pulse of ~1800 ppm diacetyl (92.9 ppm six-hour average). Rats were necropsied 18 to 20 hours after exposure. Diacetyl inhalation caused epithelial necrosis and suppurative to fibrinosuppurative inflammation in the nose, larynx, trachea, and bronchi. Bronchi were affected at diacetyl concentrations of 294.6 ppm or greater; the trachea and larynx were affected at diacetyl concentrations of 224 ppm or greater. Both pulsed and continuous exposure patterns caused epithelial injury. The nose had the greatest sensitivity to diacetyl. Ultrastructural changes in the tracheal epithelium included whorling and dilation of the rough endoplasmic reticulum, chromatin clumping beneath the nuclear membrane, vacuolation, increased inter-cellular space and foci of denuded basement membrane. Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1177/0192623307312694
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2056753-4
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