Kooperativer Bibliotheksverbund

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Format: Online-Ressource (XVIII, 532 p. 66 illus., 52 illus. in color, digital)

ISBN: 9781461458579

Series Statement: Advances in Biochemistry in Health and Disease 6

Content: Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development

Note: Description based upon print version of record , Biochemical Basis and Therapeutic Implications of Angiogenesis; Preface; Contents; Contributors; Part I:Molecular Mechanisms of Angiogenesis; Chapter 1: Endothelial Growth Factor Receptors in Angiogenesis; 1.1 Introduction: The Signaling Axes Behind Angiogenesis; 1.2 The VEGF Axis; 1.2.1 VEGF Structure and Function; 1.2.1.1 The VEGF Receptors; VEGFR-1; VEGFR-2; VEGFR-3; 1.3 Co-receptors; 1.4 The Role of the Endothelial Growth Factor Receptors in Angiogenesis and Neovascularization; 1.4.1 The Role of the Endothelial Growth Factor Receptors in Tumorigenesis; 1.4.1.1 VEGFR-1; 1.4.1.2 VEGFR-2 , 1.4.1.3 VEGFR-31.4.1.4 Prognosis; 1.4.1.5 Metastasis; 1.4.1.6 Autocrine Signaling; 1.4.1.7 Therapeutic Applications; 1.4.2 The Eye; 1.4.2.1 Therapeutic Applications; 1.4.3 Pro-angiogenic Therapies; 1.5 Conclusion; References; Chapter 2: Role of Transforming Growth Factor Beta in Angiogenesis; 2.1 TGFb Molecule Family: Sources, Activation, and Regulation of Transcription; 2.1.1 The TGFb Family; 2.1.2 TGFb Sources; 2.1.3 Synthesis and Activation of TGFb; 2.1.4 Regulation of Transcription by TGFb; 2.1.5 TGFb's Role in Angiogenesis; 2.2 TGFb Receptors and Signaling; 2.2.1 Canonical Smad Signaling , 2.2.2 Noncanonical Signaling Pathways2.2.2.1 MAPK; 2.2.2.2 Rho-GTPase; 2.2.2.3 PI3K (AKT); 2.3 TGFb and Endothelial Sprouting, Proliferation, and Permeability; 2.3.1 Endothelial Sprouting; 2.3.2 Endothelial Permeability; 2.3.3 Endothelial Proliferation and Migration; 2.4 TGFb Co-receptors in Angiogenesis; 2.4.1 Regulation of TGFb Ligand Access to Co-receptors; 2.5 TGFb and Vascular Mural Cells; 2.6 Pathological Angiogenesis; 2.6.1 HHT; 2.6.2 Organ Fibrosis; 2.6.3 Cancer; 2.7 Conclusion; References; Chapter 3: Role of Cytokines in Angiogenesis: Turning It On and Off; 3.1 Introduction , 3.2 The Sequential Steps of Angiogenesis: Vessel Branching, Maturation, and Quiescence3.3 The Players; 3.4 VEGF; 3.5 Notch; 3.6 FGF; 3.7 Ephrin and Ephrin Receptors; 3.8 TGF-b; 3.9 Platelet-Derived Growth Factor; 3.10 Angiopoietins and Tie Receptors; 3.11 Chemokines and G Protein-Coupled Receptors; 3.12 Inhibitors of Angiogenesis; 3.13 Cytokines in Tumor Angiogenesis; 3.14 Conclusion; References; Chapter 4: Neuropeptides and Angiogenesis; 4.1 Introduction; 4.2 Neuropeptide Y; 4.3 NPY and Angiogenesis; 4.4 Substance P; 4.5 SP and Angiogenesis; 4.6 Calcitonin Gene-Related Peptide , 4.7 CGRP and Angiogenesis4.8 Vasoactive Intestinal Peptide; 4.9 VIP and Angiogenesis; 4.10 Somatostatin; 4.11 Somatostatin and Angiogenesis; 4.12 Conclusions; References; Chapter 5: Role of Integrins in Angiogenesis; 5.1 Introduction; 5.2 Bidirectional Signaling by Integrins Regulates Cellular Fate; 5.3 Integrin Binding to Proteolytic Protein Fragments; 5.4 Cross talk of Integrins with Other Signaling Pathways; 5.4.1 Notch Signaling; 5.4.2 VEGF Signaling; 5.4.3 TGF-b Signaling; 5.5 Integrin Inhibition in Tumor Angiogenesis; 5.6 Integrin Inhibitors in Clinical Development; 5.6.1 Cilengitide , 5.6.2 ATN-161 , Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index.

Additional Edition: ISBN 9781461458562

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-45856-2

Language: English

DOI: 10.1007/978-1-4614-5857-9

URL: Volltext

URL: Volltext  (lizenzpflichtig)

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Format: Online-Ressource (XI, 569 p. 80 illus., 48 illus. in color, digital)

ISBN: 9781461459309

Series Statement: Advances in Biochemistry in Health and Disease 5

Additional Edition: ISBN 9781461459293

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-45929-3

Language: English

DOI: 10.1007/978-1-4614-5930-9

URL: Volltext

URL: Cover

UID:

Format: Online-Ressource (XVII, 465 p. 74 illus., 38 illus. in color, digital)

ISBN: 9781461452034

Series Statement: Advances in Biochemistry in Health and Disease 4

Content: The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to α-adrenoceptor and β-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.

Note: Description based upon print version of record , Cardiac Adaptations; Preface; Contents; Contributors; Part I Developmental Aspects of CardiacAdaptation; 1 Comparative Aspects of Cardiac Adaptation; Abstract; 1.1…Introduction; 1.2…Comparative Anatomy; 1.3…Relationship Between Heart and Body Weights in the Animal Kingdom; 1.4…Comparative Aspects of the Myocardial Structure/Blood Supply Relationship; 1.5…The Role of Compact Layer in the Adaptive Growth of the Poikilothermic Heart; 1.6…Cardiac Energy Metabolism in Poikilotherms; 1.7…Cold Adaptation of the Poikilothermic Heart , 1.8…AdaptationAdaptation of the Poikilothermic Heart to Chronic Hypoxia1.9…Conclusions; Acknowledgments; References; 2 Molecular Mechanisms of Cardiac Development; Abstract; 2.1…Introduction to CardiogenesisCardiogenesis; 2.2…Transcriptional Regulators of CardiogenesisCardiogenesis; 2.2.1 Nkx2-5; 2.2.2 MEF2C; 2.2.3 Hand1/Hand2; 2.2.4 Tbx5; 2.2.5 Gata4; 2.2.6 Second Heart Field; 2.2.7 Isl1; 2.2.8 Tbx1; 2.2.9 Hand2; 2.3…Proepicardial Organ and Epicardium; 2.3.1 Tbx18; 2.3.2 Wilms Tumor 1; 2.3.3 Epicardially-Derived Cardiac Endothelial Cells; 2.4…miRNAs and Cardiac Development , 3.4.1 Fetal Guinea Pig Model3.4.2 Genetic Mouse Models; 3.5…Human Fetal Studies; 3.5.1 Hypoplastic Left Heart Syndrome; 3.5.2 Abnormal Hemodynamics in Non-Cardiac Malformations; 3.6…Adaptations in Early Postnatal Period; 3.6.1 Physiological Changes After Birth; 3.6.2 Differences in Reaction to Pressure Overload; 3.6.3 Increased Regenerative Potential; 3.6.4 Implications for Neonatal Cardiac Surgery; 3.7…Conclusions and Perspectives; Conflict of Interests:; References; 4 HypoxiaHypoxia and Mechanical Factors Drive Coronary Vascular DevelopmentDevelopment; Abstract; 4.1…Introduction , 4.2…Hypoxia and Neovascularization: General Concepts4.2.1 HIFs Activate Multiple Vascular Growth Factors; 4.2.2 HypoxiaHypoxia Upregulates VEGFVEGF and VEGFR-1 Signaling; 4.2.3 HypoxiaHypoxia and Vessel Sprouting; 4.3…Hypoxia Signaling During Coronary Development; 4.3.1 Derivation of Coronary Vessel Cells; 4.3.2 In Vivo Studies; 4.3.3 Experimentally-Induced HypoxiaHypoxia in Vitro; 4.3.4 Hypoxic Induces Embryonic Stem Cells; 4.3.5 Fetal Coronary DevelopmentDevelopment: Responses to Hypoxemia; 4.3.6 HypoxiaHypoxia and Blood Flow Induce Coronary Growth , 4.3.7 Nitric Oxide and High Coronary Blood Flow , Comparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease..

Additional Edition: ISBN 9781461452027

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-45202-7

Language: English

DOI: 10.1007/978-1-4614-5203-4

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (XV, 403 p. 84 illus., 37 illus. in color, online resource)

ISBN: 9781461492337

Series Statement: Advances in Biochemistry in Health and Disease 7

Content: Proteases form one of the largest and most diverse families of enzymes known. Once considered primarily as “enzymes of digestion,” it is now clear that proteases are involved in every aspect of cellular function. Members of the diverse families of proteases act to promote cellular proteolysis found in nature, and their deregulation may result in different pathophysiological conditions, such as tumor progression, vascular remodeling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, and Alzheimer’s disease. Many micro-organisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases. Proteases in Health and Disease represents a comprehensive overview of the fascinating field of proteases by various renowned experts, and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Part A, Molecular and Biochemical Aspects of Proteases, illustrates some of the major proteases, such as calpains, matrix metalloproteases, fibrinolytic serine proteases, and aspartic proteases, which play a significant role in a variety of pathologies and may be a target for therapy either by their up regulation or down regulation. Part B, Involvement of Proteases in Diseases Processes, deals with the functional roles of the individual proteases in the progression of diseases such as cardiovascular and inflammatory lung disease, malaria, cholera, autism spectrum disorder, hepatitis, and ischemia-reperfusion injury induced cardiac diseases. With this multi-disciplinary scope, the book bridges the gap between fundamental research and biomedical and pharmaceutical applications, making this a thought-provoking reading for basic and applied scientists engaged in biomedical research. About the Editors: Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years. Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting th ...

Note: Description based upon print version of record , Part A: Molecular and Biochemical Aspects of Proteases1. An Overview of Endoplasmic Reticulum Calpain System -- 2. Mitochondrial Calpains: Who, What, Where, When and Why? -- 3. Role of Calpains in Calmodulin Regulated Systems -- 4. Exercise and Matrix Metalloproteases: A Brief Overview -- 5. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression -- 6. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential -- 7. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells -- 8. Cysteine Proteases of Human Malaria Parasites -- 9. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets -- 10. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-like Proteases -- 11. Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry -- Part B: Involvement of Proteases in Disease Processes -- 12. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes -- 13. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum -- 14. Proteases in Vibrio cholerae and Their Role in Pathogenesis -- 15. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura -- 16. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome -- 17. Matrix Metalloproteinases in Bone Health and Disease -- 18. Escalated Expression of Matrix Metalloproteinases in Osteoarthritis -- 19. Role of Proteases in Autism Spectrum Disorder -- 20. Role of Proteases in the Management of Hepatitis C Virus -- 21. Role of Protease in Inflammatory Lung Diseases -- 22. Involvement of Some Proteolytic Enzymes in Cardiac Dysfunction Due to Ischemia-Reperfusion Injury.

Additional Edition: ISBN 9781461492320

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-146-149-232-0

Language: English

DOI: 10.1007/978-1-4614-9233-7

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover