In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 9, No. 5 ( 1976-05), p. 852-855
Abstract:
The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against Staphylococcus aureus, Streptococcus pyogenes , and Diplococcus pneumoniae . In contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including Haemophilus influenzae , the most striking disparities being noted with indole-positive Proteus and Enterobacter. Bacteroides fragilis was more susceptible to cefoxitin than to cefamandole or cefazolin (median minimal inhibitory concentration, approximately 8, 32, and 32 μg/ml, respectively); cephalothin exhibited still less activity against this species. The majority of other anaerobes were inhibited by relatively low concentrations of all four cephalosporins. The results indicate a potentially valuable role for cefamandole against facultative gram-negative bacilli, including H. influenzae , but no exceptional activity against anaerobes.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1976
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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